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Adler et al., 2022 - Google Patents

RNA-targeting CRISPR-Cas13 provides broad-spectrum phage immunity

Adler et al., 2022

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Document ID
12491698357855578604
Author
Adler B
Hessler T
Cress B
Mutalik V
Barrangou R
Banfield J
Doudna J
Publication year
Publication venue
bioRxiv

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Snippet

CRISPR-Cas13 proteins are RNA-guided RNA nucleases that defend against invasive phages through general, non-specific RNA degradation upon complementary target transcript binding. Despite being RNA nucleases, Cas13 effectors are capable of inhibiting …
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