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EP0429585A4 - Cytochalasin compositions and therapeutic methods - Google Patents

Cytochalasin compositions and therapeutic methods

Info

Publication number
EP0429585A4
EP0429585A4 EP19900907829 EP90907829A EP0429585A4 EP 0429585 A4 EP0429585 A4 EP 0429585A4 EP 19900907829 EP19900907829 EP 19900907829 EP 90907829 A EP90907829 A EP 90907829A EP 0429585 A4 EP0429585 A4 EP 0429585A4
Authority
EP
European Patent Office
Prior art keywords
cytochalasin
compositions
therapeutic methods
therapeutic
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900907829
Other versions
EP0429585A1 (en
Inventor
Thomas P. Fondy
Dennis Bogyo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syracuse University
Original Assignee
Syracuse University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syracuse University filed Critical Syracuse University
Publication of EP0429585A1 publication Critical patent/EP0429585A1/en
Publication of EP0429585A4 publication Critical patent/EP0429585A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP19900907829 1989-04-28 1990-04-27 Cytochalasin compositions and therapeutic methods Withdrawn EP0429585A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US345010 1982-02-02
US34501089A 1989-04-28 1989-04-28

Publications (2)

Publication Number Publication Date
EP0429585A1 EP0429585A1 (en) 1991-06-05
EP0429585A4 true EP0429585A4 (en) 1992-03-25

Family

ID=23353087

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900907829 Withdrawn EP0429585A4 (en) 1989-04-28 1990-04-27 Cytochalasin compositions and therapeutic methods

Country Status (4)

Country Link
EP (1) EP0429585A4 (en)
JP (1) JPH03505744A (en)
CA (1) CA2031520A1 (en)
WO (1) WO1990013293A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250563A (en) * 1991-09-25 1993-10-05 Merck & Co., Inc. Inhibitors of HIV protease
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
WO1993011763A1 (en) * 1991-12-09 1993-06-24 Usher Thomas C Use of cytochalasins for inhibiting viral replication
US6395494B1 (en) 1993-05-13 2002-05-28 Neorx Corporation Method to determine TGF-β
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5342926A (en) * 1993-06-08 1994-08-30 The Regents Of The University Of California Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport
US7611533B2 (en) 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
ES2388248T3 (en) † 1997-03-31 2012-10-11 Boston Scientific Scimed Limited Dosage form comprising taxol in crystalline form
US6787132B1 (en) * 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
EP1033971B1 (en) * 1997-12-04 2009-09-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
DE10115740A1 (en) 2001-03-26 2002-10-02 Ulrich Speck Preparation for restenosis prophylaxis
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
DE10244847A1 (en) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medical device for drug delivery
JP5397692B2 (en) * 2007-11-28 2014-01-22 国立大学法人名古屋大学 Malignant melanoma antigen expression increasing agent and use thereof
US11007176B2 (en) 2019-02-19 2021-05-18 Tzu Chi University Use of actin depolymerizing agents for the treatment of anxiety disorders
CN110563634B (en) * 2019-09-09 2020-12-08 湖南省中医药研究院 Indole cytochalasin compound and preparation method and application thereof
CN111249445B (en) * 2020-02-27 2022-11-15 广东医科大学 Cytochalasin H soft capsule and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291151A1 (en) * 1984-08-13 1988-11-17 Harry H. Leveen Compositions comprising phlorizin derivatives for treatment of cancer
EP0297946A2 (en) * 1987-06-19 1989-01-04 Syracuse University Cytochalasin purification methods and compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0291151A1 (en) * 1984-08-13 1988-11-17 Harry H. Leveen Compositions comprising phlorizin derivatives for treatment of cancer
EP0297946A2 (en) * 1987-06-19 1989-01-04 Syracuse University Cytochalasin purification methods and compositions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 32, no. 6, 1991, pages 400-405, Springer Verlag; D. BOGYO et al.: "Cytochalasin-B-induced immunosuppression of murine allogeneic anti-tumor response and the effect of recombinant human interleukin-2" *
CELLULAR IMMUNOLOGY, vol. 69, 1982, pages 235-247, Academic Press, Inc.; S. STOSIC-GRUJICIC et al.: "Modulation of interleukin 1 production by activated macrophages: in vitro action of hydrocortisone, colchicine and cytochalasin B1" *
See also references of WO9013293A1 *

Also Published As

Publication number Publication date
EP0429585A1 (en) 1991-06-05
CA2031520A1 (en) 1990-10-29
JPH03505744A (en) 1991-12-12
WO1990013293A1 (en) 1990-11-15

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