EP0618923A4 - PEPTIDIC NUCLEIC ACIDS AND THEIR EFFECT ON GENETIC MATERIAL. - Google Patents

PEPTIDIC NUCLEIC ACIDS AND THEIR EFFECT ON GENETIC MATERIAL.

Info

Publication number: EP0618923A4
Authority: EP; European Patent Office
Prior art keywords: effect; nucleic acids; genetic material; peptidic nucleic; peptidic
Prior art date: 1991-12-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93901215A

Other languages

German (de)

French (fr)

Other versions

EP0618923A1 (en

Inventor

Stephen A Thomson

Stewart A Noble

Daniel J Ricca

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

Glaxo Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-18

Filing date

1992-12-17

Publication date

1998-05-20

1992-12-17 Application filed by Glaxo Inc filed Critical Glaxo Inc

1994-10-12 Publication of EP0618923A1 publication Critical patent/EP0618923A1/en

1998-05-20 Publication of EP0618923A4 publication Critical patent/EP0618923A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Polymers & Plastics (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)

EP93901215A 1991-12-18 1992-12-17 PEPTIDIC NUCLEIC ACIDS AND THEIR EFFECT ON GENETIC MATERIAL. Withdrawn EP0618923A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US80966191A	1991-12-18	1991-12-18
US809661		1991-12-18
PCT/US1992/010921 WO1993012129A1 (en)	1991-12-18	1992-12-17	Peptide nucleic acids and their effect on genetic material

Publications (2)

Publication Number	Publication Date
EP0618923A1 EP0618923A1 (en)	1994-10-12
EP0618923A4 true EP0618923A4 (en)	1998-05-20

Family

ID=25201908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93901215A Withdrawn EP0618923A4 (en)	1991-12-18	1992-12-17	PEPTIDIC NUCLEIC ACIDS AND THEIR EFFECT ON GENETIC MATERIAL.

Country Status (10)

Country	Link
EP (1)	EP0618923A4 (en)
JP (1)	JPH07502509A (en)
AU (2)	AU3325493A (en)
CA (1)	CA2125966A1 (en)
FI (1)	FI942935L (en)
MX (1)	MX9207334A (en)
NO (1)	NO942327D0 (en)
NZ (1)	NZ246473A (en)
WO (1)	WO1993012129A1 (en)
ZA (1)	ZA929764B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK51092D0 (en)	1991-05-24	1992-04-15	Ole Buchardt	OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF
US7223833B1 (en)	1991-05-24	2007-05-29	Isis Pharmaceuticals, Inc.	Peptide nucleic acid conjugates
US6441130B1 (en)	1991-05-24	2002-08-27	Isis Pharmaceuticals, Inc.	Linked peptide nucleic acids
US6713602B1 (en)	1991-05-24	2004-03-30	Ole Buchardt	Synthetic procedures for peptide nucleic acids
US6451968B1 (en) *	1991-05-24	2002-09-17	Isis Pharmaceuticals, Inc.	Peptide nucleic acids
US5539082A (en) *	1993-04-26	1996-07-23	Nielsen; Peter E.	Peptide nucleic acids
US6228982B1 (en) *	1992-05-22	2001-05-08	Benget Norden	Double-stranded peptide nucleic acids
US6277603B1 (en)	1991-12-24	2001-08-21	Isis Pharmaceuticals, Inc.	PNA-DNA-PNA chimeric macromolecules
EP1695979B1 (en) *	1991-12-24	2011-07-06	Isis Pharmaceuticals, Inc.	Gapped modified oligonucleotides
US5700922A (en) *	1991-12-24	1997-12-23	Isis Pharmaceuticals, Inc.	PNA-DNA-PNA chimeric macromolecules
US6350853B1 (en)	1993-04-26	2002-02-26	Peter E. Nielsen	Conjugated peptide nucleic acids having enhanced cellular uptake
US5527675A (en) *	1993-08-20	1996-06-18	Millipore Corporation	Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331012A1 (en) *	1993-09-13	1995-03-16	Bayer Ag	Nucleic acid-binding oligomers with N-branching for therapy and diagnostics
EP0736027B1 (en) *	1993-12-22	2002-05-29	Perseptive Biosystems, Inc.	Guanine synthons for peptide nucleic acid synthesis and method for production
US6133444A (en) *	1993-12-22	2000-10-17	Perseptive Biosystems, Inc.	Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DK145493D0 (en) *	1993-12-23	1993-12-23	Dako As	ANTIBODY
US5539083A (en)	1994-02-23	1996-07-23	Isis Pharmaceuticals, Inc.	Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE4408533A1 (en) *	1994-03-14	1995-09-28	Hoechst Ag	PNA synthesis using a base-labile amino protecting group
DE4408534A1 (en) *	1994-03-14	1995-09-28	Hoechst Ag	Substituted N-ethyl-glycine derivatives for the production of PNA and PNA / DNA hybrids
DE4408531A1 (en) *	1994-03-14	1995-09-28	Hoechst Ag	PNA synthesis using an amino protecting group labile to weak acids
DE4427980A1 (en) *	1994-08-08	1996-02-15	Bayer Ag	Nucleic acid binding oligomers for therapy and diagnostics
EP0804456B1 (en) *	1994-10-06	2002-08-21	Isis Pharmaceuticals, Inc.	Peptide nucleic acid conjugates
AU4729796A (en) *	1994-12-28	1996-07-19	Peter E. Nielsen	Peptide nucleic acid incorporating a chiral backbone
US6465650B1 (en)	1995-03-13	2002-10-15	Aventis Pharma Deutschland Gmbh	Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
EP0840741B1 (en) *	1995-06-07	2004-04-28	Perseptive Biosystems, Inc.	Pna-dna chimeras and pna synthons for their preparation
AU7016096A (en) *	1995-10-20	1997-05-07	Trustees Of Boston University	Nucleic acid clamps
DE19653646A1 (en) *	1996-12-20	1998-06-25	Hoechst Ag	Substituted purine derivatives, processes for their preparation, agents containing them and their use
US6617422B1 (en)	1997-05-23	2003-09-09	Peter Nielsen	Peptide nucleic acid monomers and oligomers
WO1998058256A1 (en) *	1997-06-16	1998-12-23	The University Of North Carolina At Chapel Hill	PEPTIDO OLIGONUCLEOTIDES (PONs) AND THEIR COMBINATORIAL LIBRARIES
WO2000002864A1 (en) *	1998-07-10	2000-01-20	Martens Juergen	Precusors for pna-monomers
US6921812B1 (en)	2001-07-03	2005-07-26	Isis Pharmaceuticals, Inc.	Methods of modulating pharmacokinetics of oligonucleotides
BR0316363A (en)	2002-11-15	2005-10-04	Idenix Cayman Ltd	2'-branched nucleosides and flaviviridae mutation
WO2007073149A1 (en)	2005-12-22	2007-06-28	Keygene N.V.	Alternative nucleotides for improved targeted nucleotide exchange
WO2012113775A1 (en)	2011-02-21	2012-08-30	University Of Zurich	Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders
US9347095B2 (en)	2013-03-15	2016-05-24	Bio-Rad Laboratories, Inc.	Digital assays for mutation detection
AU2018240467B2 (en) *	2017-03-23	2022-09-15	Neubase Therapeutics, Inc.	Peptide nucleic acid (PNA) monomers with an orthogonally protected ester moiety

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1986005518A1 (en) *	1985-03-15	1986-09-25	James Summerton	Stereoregular polynucleotide-binding polymers
WO1992020702A1 (en) *	1991-05-24	1992-11-26	Ole Buchardt	Peptide nucleic acids

1992
- 1992-12-16 MX MX9207334A patent/MX9207334A/en unknown
- 1992-12-17 NZ NZ246473A patent/NZ246473A/en unknown
- 1992-12-17 FI FI942935A patent/FI942935L/en unknown
- 1992-12-17 WO PCT/US1992/010921 patent/WO1993012129A1/en not_active Application Discontinuation
- 1992-12-17 EP EP93901215A patent/EP0618923A4/en not_active Withdrawn
- 1992-12-17 CA CA002125966A patent/CA2125966A1/en not_active Abandoned
- 1992-12-17 JP JP5511176A patent/JPH07502509A/en active Pending
- 1992-12-17 ZA ZA929764A patent/ZA929764B/en unknown
- 1992-12-17 AU AU33254/93A patent/AU3325493A/en not_active Abandoned
1994
- 1994-06-17 NO NO942327A patent/NO942327D0/en not_active Application Discontinuation
1996
- 1996-10-21 AU AU70325/96A patent/AU7032596A/en not_active Abandoned

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1986005518A1 (en) *	1985-03-15	1986-09-25	James Summerton	Stereoregular polynucleotide-binding polymers
WO1992020702A1 (en) *	1991-05-24	1992-11-26	Ole Buchardt	Peptide nucleic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9312129A1 *

Also Published As

Publication number	Publication date
AU3325493A (en)	1993-07-19
FI942935A7 (en)	1994-07-27
FI942935L (en)	1994-07-27
NO942327D0 (en)	1994-06-17
NZ246473A (en)	1996-05-28
MX9207334A (en)	1993-08-01
JPH07502509A (en)	1995-03-16
CA2125966A1 (en)	1993-06-24
AU7032596A (en)	1997-01-16
WO1993012129A1 (en)	1993-06-24
NO942327L (en)	1994-08-17
EP0618923A1 (en)	1994-10-12
ZA929764B (en)	1993-10-13
FI942935A0 (en)	1994-06-17

Publication	Publication Date	Title
EP0618923A4 (en)	1998-05-20	PEPTIDIC NUCLEIC ACIDS AND THEIR EFFECT ON GENETIC MATERIAL.
EP0948651A4 (en)	2004-04-07	RECOMBINANT N-SMASES AND NUCLEIC ACIDS ENCODING THEM
FI933580A7 (en)	1993-10-13	Pneumococcal protein structural gene
DE4393381T1 (en)	1995-04-27	Peptides
EP0673421A4 (en)	1997-05-02	Allergenic proteins and peptides from johnson grass pollen.
FI974429L (en)	1997-12-05	Suspended peptide/protein preparations
FI954978A7 (en)	1995-11-15	Modified protein and peptide drugs
ATA901092A (en)	2003-01-15	BIODICALLY ACTIVE PEPTIDE CONTAINING PARTICLES
KR900011900A (en)	1990-08-02	Signal peptides for secreting peptides in E. coli and genes encoding them
WO1996009386A3 (en)	1996-05-02	Allelic variation of the serotonin 5ht2c receptor
DE69131381D1 (en)	1999-07-29	STRUCTURAL PROTEINS THROUGH ARTIFICIAL GENES
EP0363436A4 (en)	1990-06-26	Cloned protein g variant genes and the protein g variants expressed therefrom.
IL109367A0 (en)	1994-07-31	Dna segment comprising gene encoding insecticidal protein
EP0600278A3 (en)	1995-01-25	Glutamate receptor protein and gene.
ZA918423B (en)	1993-04-22	Proteins and nucleic acids.
IT8819791A0 (en)	1988-03-16	PEPTIDES WITH PHARMACEUTICAL ACTIVITY.
DE68907044D1 (en)	1993-07-15	ADDITION PRODUCTS FROM AN AMINO ALCOHOL AND NITRILE RUBBER.
FR2709132B1 (en)	1995-11-17	DNA fragment carrying the gene coding for the fragmentation enzyme N-acetylheparosan and the adjacent sequences allowing its expression, recombinant enzyme and its use.
WO2000029564A3 (en)	2000-11-09	Human glycine transporter type 2
EP0659884A3 (en)	1997-08-06	Carrot 16 kd protein, gene coding therefor, and plazmid containing it.
AU2168897A (en)	1997-10-17	Insect neuropeptides genes and peptides
NL1001210C1 (en)	1996-11-26	Transport and delivery trolley for feed material.
DE69729780D1 (en)	2004-08-12	Protein with ethylenediamine-N, N'-dibarnsuccinic acid: ethylenediamine lyase activity and gene coding for it
MA21307A1 (en)	1988-12-31	PLANTS THAT SUPPORT THE VOLTAGE AND METHOD FOR THEIR PREPARATIONS.
EP0876480A4 (en)	1999-10-20	ANIMALS WITH TARGETED GENE DELETION

Legal Events

Date	Code	Title	Description
1994-08-26	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1994-10-12	17P	Request for examination filed	Effective date: 19940608
1994-10-12	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1995-09-06	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: GLAXO WELLCOME INC.
1998-05-20	A4	Supplementary search report drawn up and despatched	Effective date: 19980403
1998-05-20	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1999-06-02	17Q	First examination report despatched	Effective date: 19990419
2000-05-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2000-06-21	18D	Application deemed to be withdrawn	Effective date: 19991230