EP0900081A4 - Inhibitors of farnesyl-protein transferase - Google Patents

Inhibitors of farnesyl-protein transferase

Info

Publication number: EP0900081A4
Authority: EP; European Patent Office
Prior art keywords: farnesyl; inhibitors; protein transferase; transferase; protein
Prior art date: 1996-04-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP97917604A

Other languages

German (de)

French (fr)

Other versions

EP0900081A1 (en

Inventor

Christopher J Dinsmore

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck and Co Inc

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-03

Filing date

1997-03-27

Publication date

2002-01-09

1996-05-17 Priority claimed from GBGB9610338.7A external-priority patent/GB9610338D0/en

1997-03-27 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

1999-03-10 Publication of EP0900081A1 publication Critical patent/EP0900081A1/en

2002-01-09 Publication of EP0900081A4 publication Critical patent/EP0900081A4/en

Status Withdrawn legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EP97917604A 1996-04-03 1997-03-27 Inhibitors of farnesyl-protein transferase Withdrawn EP0900081A4 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1479296P	1996-04-03	1996-04-03
US14792P		1996-04-03
GBGB9610338.7A GB9610338D0 (en)	1996-05-17	1996-05-17	Inhibitors of farnesyl-protein transferase
GB9610338		1996-05-17
PCT/US1997/004750 WO1997036591A1 (en)	1996-04-03	1997-03-27	Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number	Publication Date
EP0900081A1 EP0900081A1 (en)	1999-03-10
EP0900081A4 true EP0900081A4 (en)	2002-01-09

Family

ID=26309349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97917604A Withdrawn EP0900081A4 (en)	1996-04-03	1997-03-27	Inhibitors of farnesyl-protein transferase

Country Status (5)

Country	Link
EP (1)	EP0900081A4 (en)
JP (1)	JP2001518067A (en)
AU (1)	AU707347B2 (en)
CA (1)	CA2250587A1 (en)
WO (1)	WO1997036591A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002519428A (en)	1998-07-02	2002-07-02	メルクエンドカムパニーインコーポレーテッド	Inhibitors of prenyl-protein transferase
DK1940786T3 (en)	2005-09-16	2010-11-08	Arrow Therapeutics Ltd	Biphenyl derivatives and their use in the treatment of hepatitis C
CA2756870A1 (en)	2009-03-31	2010-10-07	Arqule, Inc.	Substituted indolo-pyridinone compounds
US9045445B2 (en)	2010-06-04	2015-06-02	Albany Molecular Research, Inc.	Glycine transporter-1 inhibitors, methods of making them, and uses thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA983495A (en) *	1972-10-11	1976-02-10	Gilbert Regnier	Procede de preparation de derives du benzodioxole
US4598079A (en) *	1981-08-20	1986-07-01	Cassella Aktiengesellschaft	2-(aryl substitued)piperazinones and nootropic compositions based thereon
WO1993021186A1 (en) *	1992-04-13	1993-10-28	Fujisawa Pharmaceutical Co., Ltd.	Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
WO1995000497A1 (en) *	1993-06-18	1995-01-05	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
US5382584A (en) *	1992-07-31	1995-01-17	Bristol-Myers Squibb Company	Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
EP0670314A1 (en) *	1993-09-22	1995-09-06	Kyowa Hakko Kogyo Co., Ltd.	Farnesyltransferase inhibitor
WO1996030343A1 (en) *	1995-03-29	1996-10-03	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
WO1996037204A1 (en) *	1995-05-24	1996-11-28	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3915981A (en) *	1973-03-16	1975-10-28	Yoshitomi Pharmaceutical	1-{8 2-(2-Chlorobenzoyl)-4-nitrophenyl{9 -2-(diethylaminomethyl)-imidazole
US5138069A (en) *	1986-07-11	1992-08-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
US4835154A (en) *	1987-06-01	1989-05-30	Smithkline Beckman Corporation	1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors
US5219856A (en) *	1992-04-06	1993-06-15	E. I. Du Pont De Nemours And Company	Angiotensin-II receptor blocking, heterocycle substituted imidazoles
US5478934A (en) *	1994-11-23	1995-12-26	Yuan; Jun	Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands
WO1996016057A1 (en) *	1994-11-23	1996-05-30	Neurogen Corporation	Certain 1-substituted aminomethyl imidazole and pyrrole derivatives; novel dopamine receptor subtype specific ligands

1997
- 1997-03-27 AU AU25879/97A patent/AU707347B2/en not_active Ceased
- 1997-03-27 WO PCT/US1997/004750 patent/WO1997036591A1/en not_active Application Discontinuation
- 1997-03-27 CA CA002250587A patent/CA2250587A1/en not_active Abandoned
- 1997-03-27 EP EP97917604A patent/EP0900081A4/en not_active Withdrawn
- 1997-03-27 JP JP53535797A patent/JP2001518067A/en active Pending

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA983495A (en) *	1972-10-11	1976-02-10	Gilbert Regnier	Procede de preparation de derives du benzodioxole
US4598079A (en) *	1981-08-20	1986-07-01	Cassella Aktiengesellschaft	2-(aryl substitued)piperazinones and nootropic compositions based thereon
WO1993021186A1 (en) *	1992-04-13	1993-10-28	Fujisawa Pharmaceutical Co., Ltd.	Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents
US5382584A (en) *	1992-07-31	1995-01-17	Bristol-Myers Squibb Company	Adenosine re-uptake inhibiting derivatives of diphenyl oxazoles, thiazoles and imidazoles
WO1995000497A1 (en) *	1993-06-18	1995-01-05	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
EP0670314A1 (en) *	1993-09-22	1995-09-06	Kyowa Hakko Kogyo Co., Ltd.	Farnesyltransferase inhibitor
WO1996030343A1 (en) *	1995-03-29	1996-10-03	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
WO1996037204A1 (en) *	1995-05-24	1996-11-28	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9736591A1 *

Also Published As

Publication number	Publication date
JP2001518067A (en)	2001-10-09
WO1997036591A1 (en)	1997-10-09
EP0900081A1 (en)	1999-03-10
AU2587997A (en)	1997-10-22
AU707347B2 (en)	1999-07-08
CA2250587A1 (en)	1997-10-09

Publication	Publication Date	Title
EP1011669A4 (en)	2001-09-12	Inhibitors of farnesyl-protein transferase
GB9604311D0 (en)	1996-05-01	Inhibitors of farnesyl-protein transferase
EP0891360A4 (en)	2002-05-15	Inhibitors of farnesyl-protein transferase
EP1045844A4 (en)	2002-08-21	Inhibitors of farnesyl-protein transferase
EP0904080A4 (en)	2001-08-01	Inhibitors of farnesyl-protein transferase
EP0891349A4 (en)	2001-01-24	Inhibitors of farnesyl-protein transferase
EP0880320A4 (en)	1999-06-16	Inhibitors of farnesyl-protein transferase
EP0891352A4 (en)	2001-08-16	Inhibitors of farnesyl-protein transferase
EP1035850A4 (en)	2001-09-12	Inhibitors of farnesyl-protein transferase
EP0891335A4 (en)	2001-08-16	Inhibitors of farnesyl-protein transferase
EP0959883A4 (en)	2001-05-09	Inhibitors of farnesyl-protein transferase
EP1035849A4 (en)	2001-09-12	Inhibitors of farnesyl-protein transferase
EP0877610A4 (en)	1999-09-15	Inhibitors of farnesyl-protein transferase
EP1023270A4 (en)	2001-04-18	Inhibitors of farnesyl-protein transferase
EP0900081A4 (en)	2002-01-09	Inhibitors of farnesyl-protein transferase
GB9721000D0 (en)	1997-12-03	Inhibitors of farnesyl-protein transferase
GB9617278D0 (en)	1996-09-25	Inhibitors of farnesyl-protein transferase
GB9605708D0 (en)	1996-05-22	Inhibitors of farnesyl-protein transferase
GB9616736D0 (en)	1996-09-25	Inhibitors of farnesyl-protein transferase
GB9614316D0 (en)	1996-09-04	Inhibitors of farnesyl-protein transferase
GB9617255D0 (en)	1996-09-25	Inhibitors of farnesyl-protein transferase
GB9617257D0 (en)	1996-09-25	Inhibitors of farnesyl-protein transferase
GB9606502D0 (en)	1996-06-05	Inhibitors of farnesyl-protein transferase
GB9613462D0 (en)	1996-08-28	Inhibitors of farnesyl-protein transferase
GB9613461D0 (en)	1996-08-28	Inhibitors of farnesyl-protein transferase

Legal Events

Date	Code	Title	Description
1999-01-22	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1999-03-10	17P	Request for examination filed	Effective date: 19981103
1999-03-10	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2002-01-02	RIC1	Information provided on ipc code assigned before grant	Free format text: 7A 61K 31/495 A, 7C 07D 403/06 B, 7C 07D 401/06 B
2002-01-09	A4	Supplementary search report drawn up and despatched	Effective date: 20011123
2002-01-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
2002-08-02	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2002-09-18	18D	Application deemed to be withdrawn	Effective date: 20020211