WO1999000373A8 - Derives de benzimidazole - Google Patents
Derives de benzimidazoleInfo
- Publication number
- WO1999000373A8 WO1999000373A8 PCT/JP1998/002885 JP9802885W WO9900373A8 WO 1999000373 A8 WO1999000373 A8 WO 1999000373A8 JP 9802885 W JP9802885 W JP 9802885W WO 9900373 A8 WO9900373 A8 WO 9900373A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- benzimidazole derivatives
- alkyl
- general formula
- medicines
- salts
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title abstract 2
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR9811273-2A BR9811273A (pt) | 1997-06-27 | 1998-06-26 | Derivados de benzimidazol |
| CA002294505A CA2294505A1 (en) | 1997-06-27 | 1998-06-26 | Benzimidazole derivatives |
| IL13367498A IL133674A0 (en) | 1997-06-27 | 1998-06-26 | Benzimidazole derivatives |
| EP98929723A EP1020452A4 (en) | 1997-06-27 | 1998-06-26 | benzimidazole derivatives |
| HK00107463.3A HK1028246B (en) | 1997-06-27 | 1998-06-26 | Benzimidazole derivatives |
| US09/446,749 US6420409B1 (en) | 1997-06-27 | 1998-06-26 | Benzimidazole derivatives |
| AU79346/98A AU748541B2 (en) | 1997-06-27 | 1998-06-26 | Benzimidazole derivatives |
| HU0002324A HUP0002324A3 (en) | 1997-06-27 | 1998-06-26 | Benzimidazole derivatives and pharmaceutical compositions containing them |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9/187696 | 1997-06-27 | ||
| JP18769697 | 1997-06-27 | ||
| JP10/76357 | 1998-03-25 | ||
| JP7635798 | 1998-03-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1999000373A1 WO1999000373A1 (fr) | 1999-01-07 |
| WO1999000373A8 true WO1999000373A8 (fr) | 2000-07-20 |
Family
ID=26417500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP1998/002885 WO1999000373A1 (fr) | 1997-06-27 | 1998-06-26 | Derives de benzimidazole |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6420409B1 (ja) |
| EP (1) | EP1020452A4 (ja) |
| KR (1) | KR20010014166A (ja) |
| CN (1) | CN1135224C (ja) |
| AR (1) | AR016108A1 (ja) |
| AU (1) | AU748541B2 (ja) |
| BR (1) | BR9811273A (ja) |
| CA (1) | CA2294505A1 (ja) |
| HU (1) | HUP0002324A3 (ja) |
| IL (1) | IL133674A0 (ja) |
| RU (1) | RU2243968C2 (ja) |
| TR (1) | TR199903277T2 (ja) |
| TW (1) | TW453999B (ja) |
| WO (1) | WO1999000373A1 (ja) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2199532C2 (ru) * | 1997-06-27 | 2003-02-27 | Фудзисава Фармасьютикал Ко., Лтд. | Сульфонамидное соединение |
| CA2327397A1 (en) * | 1998-04-06 | 1999-10-14 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives |
| EP1132087A4 (en) * | 1998-11-13 | 2002-06-26 | Fujisawa Pharmaceutical Co | REMEDIES FOR POLYKYSTIC OVARY SYNDROME |
| US6869950B1 (en) * | 1998-12-24 | 2005-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
| US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| US6525067B1 (en) | 1999-11-23 | 2003-02-25 | Pfizer Inc | Substituted heterocyclic derivatives |
| EP1149583A3 (en) * | 2000-04-13 | 2001-11-14 | Pfizer Products Inc. | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues |
| US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
| CN1585771A (zh) | 2001-11-09 | 2005-02-23 | 先灵公司 | 多环鸟嘌呤衍生物磷酸二酯酶v抑制剂 |
| AU2002349673A1 (en) * | 2001-12-03 | 2003-06-17 | Takeda Chemical Industries, Ltd. | Insulin resistance improving agents |
| FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
| US20030181461A1 (en) * | 2002-01-25 | 2003-09-25 | Lautt Wilfred Wayne | Use of phosphodiesterase antagonists to treat insulin resistance |
| BR0309875A (pt) * | 2002-05-03 | 2007-04-10 | Israel Inst For Biolog Res Isr | métodos e composições para tratamento de distúrbios do sistema nervoso periférico e novos compostos úteis para isto |
| AU2003902860A0 (en) * | 2003-06-06 | 2003-06-26 | Daicel Chemical Industries, Ltd | Benzimidazole compounds |
| SE0302573D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
| GB0400781D0 (en) * | 2004-01-14 | 2004-02-18 | Novartis Ag | Organic compounds |
| US20050197376A1 (en) * | 2004-03-02 | 2005-09-08 | Fujisawa Pharmaceutical Co. Ltd. | Concomitant drugs |
| EP1983992A4 (en) * | 2006-01-19 | 2010-08-18 | Abbott Lab | 2-IMINO-BENZIMIDAZOLES |
| WO2011063339A1 (en) * | 2009-11-23 | 2011-05-26 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors for the treatment of pulmonary hypertension |
| US9018411B2 (en) * | 2009-12-07 | 2015-04-28 | Cardioxyl Pharmaceuticals, Inc. | Bis-acylated hydroxylamine derivatives |
| IN2012DN05025A (ja) * | 2009-12-07 | 2015-10-23 | Univ Johns Hopkins | |
| JP5990106B2 (ja) * | 2011-01-28 | 2016-09-07 | 佐藤製薬株式会社 | 縮環化合物 |
| CN108368068A (zh) | 2015-12-11 | 2018-08-03 | 帝人制药株式会社 | 氨基唑衍生物 |
| US10730752B2 (en) | 2016-05-03 | 2020-08-04 | Virginia Commonwealth University | Heteroatom-doped porous carbons for clean energy applications and methods for their synthesis |
| US12234205B1 (en) | 2024-05-22 | 2025-02-25 | King Saud University | Sulfonylhydrazide derivatives as anticancer agents |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE676196C (de) | 1936-08-21 | 1939-05-30 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung von Imidazolverbindungen |
| US3152142A (en) | 1962-05-24 | 1964-10-06 | Dow Chemical Co | Benzimidazole compounds |
| FR2291749A1 (fr) | 1974-11-20 | 1976-06-18 | Delalande Sa | Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique |
| JPS51133267A (en) | 1975-05-08 | 1976-11-18 | Lilly Co Eli | Substituted 11sulphonyl benzimidazole |
| US4179505A (en) | 1977-03-30 | 1979-12-18 | Janssen Pharmaceutica N.V. | 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives |
| US4243806A (en) | 1979-06-13 | 1981-01-06 | Janssen Pharmaceutica N.V. | 5-[4-(Diarylmethyl)-1-piperazinylalkyl]benzimidazole derivatives |
| GB2053215B (en) | 1979-06-25 | 1983-04-07 | May & Baker Ltd | Benzimidazole derivatives |
| JPS625966A (ja) | 1985-07-03 | 1987-01-12 | Nippon Shinyaku Co Ltd | ベンズイミダゾ−ル誘導体 |
| NZ221729A (en) | 1986-09-15 | 1989-07-27 | Janssen Pharmaceutica Nv | Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions |
| ZA899367B (en) * | 1988-12-22 | 1990-08-29 | Yamanouchi Pharma Co Ltd | 4,5,6,7-tetrahydrobenzimidazole derivatives |
| CA2004911A1 (en) | 1988-12-22 | 1990-06-22 | Mitsuaki Ohta | 4,5,6,7-tetrahydrobenzimidazole derivatives |
| DE3928177A1 (de) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| JPH05507469A (ja) | 1990-04-13 | 1993-10-28 | スミスクライン・ビーチャム・コーポレイション | 置換ベンズイミダゾール |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5703110A (en) | 1990-04-27 | 1997-12-30 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
| RU1836357C (ru) | 1990-07-23 | 1993-08-23 | Др.Карл Томэ ГмбХ | Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами |
| DE4023369A1 (de) * | 1990-07-23 | 1992-01-30 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| PT98674B (pt) * | 1990-08-15 | 1999-01-29 | British Bio Technology | Processo para a preparacao de compostos que sao antagonistas do factor de activacao de plaquetas por exemplo derivados de imidazole e de seus intermedriarios |
| US5602127A (en) | 1991-02-06 | 1997-02-11 | Karl Thomae Gmbh | (Alkanesultam-1-yl)-benzimidazol-1-yl)-1yl)-methyl-biphenyls useful as angiotensin-II antagonists |
| DE4224133A1 (de) * | 1992-07-22 | 1994-01-27 | Thomae Gmbh Dr K | Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5594003A (en) | 1991-02-06 | 1997-01-14 | Dr. Karl Thomae Gmbh | Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biphenyls useful as angiotensin-II antagonists |
| US5614519A (en) | 1991-02-06 | 1997-03-25 | Karl Thomae Gmbh | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists |
| SI9210098B (sl) * | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo |
| US5407835A (en) | 1991-07-31 | 1995-04-18 | Abbott Laboratories | Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids |
| GB9121776D0 (en) | 1991-10-14 | 1991-11-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives and process for preparation thereof |
| DE4237557A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Substituierte Benzimidazole |
| JPH0853424A (ja) | 1994-08-11 | 1996-02-27 | Kureha Chem Ind Co Ltd | ベンズイミダゾールスルホン酸アミド誘導体 |
| GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
| BR9612434A (pt) * | 1995-12-28 | 1999-12-28 | Fujiwasa Pharmaceutical Co Ltd | Derivados de benzimidazol |
-
1998
- 1998-06-25 TW TW087110304A patent/TW453999B/zh not_active IP Right Cessation
- 1998-06-26 CA CA002294505A patent/CA2294505A1/en not_active Abandoned
- 1998-06-26 TR TR1999/03277T patent/TR199903277T2/xx unknown
- 1998-06-26 US US09/446,749 patent/US6420409B1/en not_active Expired - Fee Related
- 1998-06-26 BR BR9811273-2A patent/BR9811273A/pt not_active IP Right Cessation
- 1998-06-26 WO PCT/JP1998/002885 patent/WO1999000373A1/ja not_active Application Discontinuation
- 1998-06-26 AU AU79346/98A patent/AU748541B2/en not_active Ceased
- 1998-06-26 KR KR1019997012237A patent/KR20010014166A/ko not_active Withdrawn
- 1998-06-26 HU HU0002324A patent/HUP0002324A3/hu unknown
- 1998-06-26 AR ARP980103128A patent/AR016108A1/es unknown
- 1998-06-26 RU RU2000101811/04A patent/RU2243968C2/ru not_active IP Right Cessation
- 1998-06-26 IL IL13367498A patent/IL133674A0/xx unknown
- 1998-06-26 CN CNB988085798A patent/CN1135224C/zh not_active Expired - Fee Related
- 1998-06-26 EP EP98929723A patent/EP1020452A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1020452A1 (en) | 2000-07-19 |
| TW453999B (en) | 2001-09-11 |
| TR199903277T2 (xx) | 2000-07-21 |
| BR9811273A (pt) | 2000-07-18 |
| RU2243968C2 (ru) | 2005-01-10 |
| KR20010014166A (ko) | 2001-02-26 |
| US6420409B1 (en) | 2002-07-16 |
| HUP0002324A3 (en) | 2001-07-30 |
| AR016108A1 (es) | 2001-06-20 |
| WO1999000373A1 (fr) | 1999-01-07 |
| HUP0002324A2 (hu) | 2001-05-28 |
| CN1268123A (zh) | 2000-09-27 |
| CA2294505A1 (en) | 1999-01-07 |
| CN1135224C (zh) | 2004-01-21 |
| HK1028246A1 (en) | 2001-02-09 |
| AU7934698A (en) | 1999-01-19 |
| AU748541B2 (en) | 2002-06-06 |
| IL133674A0 (en) | 2001-04-30 |
| EP1020452A4 (en) | 2003-04-02 |
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