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Çalışkan et al., 2011 - Google Patents

Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils

Çalışkan et al., 2011

Document ID
4312832625978258979
Author
Çalışkan B
Luderer S
Özkan Y
Werz O
Banoglu E
Publication year
Publication venue
European journal of medicinal chemistry

External Links

Snippet

We recently presented that compounds 4a–b moderately inhibited leukotriene (LT) formation in human neutrophils. For structural derivatization of 4a–b, novel thirty-six title compounds were synthesized and led to more potent inhibition of LT biosynthesis in activated human …
Continue reading at www.sciencedirect.com (other versions)

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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