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Ma et al., 2021 - Google Patents

An enzyme-mediated bioorthogonal labeling method for genome-wide mapping of 5-hydroxymethyluracil

Ma et al., 2021

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Document ID
4907044463159786199
Author
Ma C
Li L
Shao W
Ding J
Cai X
Lun Z
Yuan B
Feng Y
Publication year
Publication venue
Chemical Science

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Snippet

DNA 5-hydroxymethyluracil (5hmU) is a thymine modification existing in the genomes of various organisms. The post-replicative formation of 5hmU occurs via hydroxylation of thymine by ten-eleven translocation (TET) dioxygenases in mammals and J-binding proteins …
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