[go: up one dir, main page]

Yildiz et al., 2013 - Google Patents

Allosteric inhibition of the NS2B-NS3 protease from dengue virus

Yildiz et al., 2013

View PDF
Document ID
5678894657769148508
Author
Yildiz M
Ghosh S
Bell J
Sherman W
Hardy J
Publication year
Publication venue
ACS chemical biology

External Links

Snippet

Dengue virus is the flavivirus that causes dengue fever, dengue hemorrhagic disease, and dengue shock syndrome, which are currently increasing in incidence worldwide. Dengue virus protease (NS2B-NS3pro) is essential for dengue virus infection and is thus a target of …
Continue reading at pmc.ncbi.nlm.nih.gov (PDF) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense
    • C12N2770/00011—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense ssRNA Viruses positive-sense
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Similar Documents

Publication Publication Date Title
Yildiz et al. Allosteric inhibition of the NS2B-NS3 protease from dengue virus
Wang et al. A small-molecule dengue virus entry inhibitor
Yao et al. Discovery, X-ray crystallography and antiviral activity of allosteric inhibitors of flavivirus NS2B-NS3 protease
Othman et al. Docking of noncompetitive inhibitors into dengue virus type 2 protease: understanding the interactions with allosteric binding sites
Hill et al. The unique cofactor region of Zika virus NS2B–NS3 protease facilitates cleavage of key host proteins
Deng et al. Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping
Tomlinson et al. New approaches to structure-based discovery of dengue protease inhibitors
Nitsche et al. Biochemistry and medicinal chemistry of the dengue virus protease
Raut et al. A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture
Dwivedi et al. In silico evaluation of inhibitory potential of triterpenoids from Azadirachta indica against therapeutic target of dengue virus, NS2B-NS3 protease
Hariono et al. Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling
Brecher et al. The flavivirus protease as a target for drug discovery
Cregar-Hernandez et al. Small molecule pan-dengue and West Nile virus NS3 protease inhibitors
Norshidah et al. Assessing the potential of NS2B/NS3 protease inhibitors biomarker in curbing dengue virus infections: in silico vs. in vitro approach
Kumar et al. Mechanistic insights into Zika virus NS3 helicase inhibition by epigallocatechin-3-gallate
Lim et al. Curcumin allosterically inhibits the dengue NS2B-NS3 protease by disrupting its active conformation
Hassandarvish et al. In silico study on baicalein and baicalin as inhibitors of dengue virus replication
Cannalire et al. Pyridobenzothiazolones exert potent anti-dengue activity by hampering multiple functions of NS5 polymerase
Osman et al. 3, 5-Bis (arylidene)-4-piperidones as potential dengue protease inhibitors
Indu et al. Antiviral activity of astragaloside II, astragaloside III and astragaloside IV compounds against dengue virus: computational docking and in vitro studies
Steuber et al. Recent advances in targeting viral proteases for the discovery of novel antivirals
Dwivedi et al. Identification of new potent inhibitors of dengue virus NS3 protease from traditional Chinese medicine database
Hill et al. Cysteine disulfide traps reveal distinct conformational ensembles in dengue virus NS2B-NS3 protease
Lin et al. Dengue protease substrate recognition: binding of the prime side
Shiryaev et al. Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase