Bril, 2003 - Google Patents
Factor VIII inhibitors in mild haemophilia ABril, 2003
View PDF- Document ID
- 5840015253163507368
- Author
- Bril W
- Publication year
External Links
Snippet
The X-linked bleeding disorder haemophilia A is due to a deficiency or functional defect of coagulation factor VIII. The bleeding tendency can be corrected by administration of factor VIII concentrates. A serious complication of factor VIII replacement therapy is the …
- 108010054218 Factor VIII 0 title abstract description 90
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses, e.g. hepatitis E virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114539414A (en) | Anti-coagulation factor XI antibodies | |
| JP4660189B2 (en) | Compositions, methods and kits related to antiplatelet autoantibodies and inhibitors thereof | |
| van den Brink et al. | Human antibodies with specificity for the C2 domain of factor VIII are derived from VH1 germline genes | |
| JP2009528285A (en) | Anti-idiotype antibody neutralizing inhibitory activity of inhibitory antibody against C1 domain of factor VIII | |
| TW201802120A (en) | Anticoagulant factor XI antibody | |
| Van den Brink et al. | Two classes of germline genes both derived from the VH1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII | |
| BR112020010016A2 (en) | reversal binding agents for anti-factor xi / xia antibodies and their uses | |
| Spatz et al. | Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia. | |
| van den Brink et al. | Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII | |
| Mo et al. | The B cell response to autologous type II collagen: biased V gene repertoire with V gene sharing and epitope shift. | |
| US20080206254A1 (en) | Novel Anti-Factor VIII Antibodies | |
| van den Brink et al. | Molecular analysis of human anti-factor VIII antibodies by V gene phage display identifies a new epitope in the acidic region following the A2 domain: Presented in part at the 41st Annual Meeting of the American Society of Hematology, December 3-7, 1999, New Orleans, LA. | |
| CA2551317A1 (en) | Anti-idiotypic antibody neutralizing the inhibitory action of an inhibitory antibody for factor viii | |
| KR100925348B1 (en) | Human-type anti-blood coagulation factor ? antibody | |
| CA2327587C (en) | Methods for treatment of haemophilia a patients using human anti-human fviii antibodies | |
| Bril | Factor VIII inhibitors in mild haemophilia A | |
| CA2494698C (en) | Anti-idiotypic antibodies against factor viii inhibitor and uses thereof | |
| Clausen et al. | Clonally-related immunoglobulin VH domains and nonrandom use of DH gene segments in rheumatoid arthritis synovium | |
| Voorberg et al. | Phage display technology: a tool to explore the diversity of inhibitors to blood coagulation factor VIII | |
| Watkins et al. | Molecular studies of anti‐HLA‐A2 using light‐chain shuffling: a structural model for HLA antibody binding | |
| Devaux et al. | Preferential expression of VK21E light chains on IdX Ia. 7 positive monoclonal anti-IE antibodies. | |
| Stewart et al. | Rhesus monkeys and baboons develop clotting factor VIII inhibitors in response to porcine endothelial cells or islets | |
| Gharagozlou et al. | Characterization of human hybridoma clones isolated from hemophilia patients with specificity for different domains of coagulating factor VIII | |
| Lönnblom | Antibodies as pathogenic factors and biomarkers in rheumatoid arthritis | |
| Mouse | Major Cross-Reactive Idiotype of the |