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Zhang et al., 2024 - Google Patents

Preferential cleavage of upstream targets in concatenated miRNA/siRNA target sites support a 5′-3′ scanning model for RISC target recognition

Zhang et al., 2024

Document ID
7079616635830477353
Author
Zhang M
Zhang C
Publication year
Publication venue
Biochemical and Biophysical Research Communications

External Links

Snippet

RNA interference (RNAi) is becoming medicine for curing human diseases. Still, we lack a thorough understanding of some fundamental aspects of RNAi that affect its efficiency and accuracy. One such question is how RNA-induced silencing complex (RISC) can efficiently …
Continue reading at www.sciencedirect.com (other versions)

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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