[go: up one dir, main page]

Lundblad et al., 1976 - Google Patents

[14] Thrombin

Lundblad et al., 1976

Document ID
8911458096417508021
Author
Lundblad R
Kingdon H
Mann K
Publication year
Publication venue
Methods in enzymology

External Links

Snippet

Publisher Summary Thrombin is the enzyme involved in the final step in the coagulation of mammalian blood. This step involves the conversion of fibrinogen to fibrin through the cleavage of four arginyl–glycyl peptide bonds. Thrombin therefore is a highly specific …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

Similar Documents

Publication Publication Date Title
Lundblad et al. [14] Thrombin
Markwardt [69] Hirudin as an inhibitor of thrombin
Laudano et al. Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers
Nolan et al. [17] Ancrod, the coagulating enzyme from Malayan pit viper (Agkistrodon rhodostoma) venom
Walker Protein S and the regulation of activated protein C
Lundblad et al. Preparation and partial characterization of two forms of bovine thrombin
Kisiel et al. Proteolytic activation of protein C from bovine plasma
Mann [13] Prothrombin
McMullen et al. Amino acid sequence of the heavy chain of human alpha-factor XIIa (activated Hageman factor).
Salvesen et al. Primary structure of the reactive site of human C1-inhibitor.
Suzuki et al. Thrombin-catalyzed activation of human coagulation factor V.
Andersson et al. Purification and characterization of human factor IX
Ichinose et al. Localization of the binding site of tissue-type plasminogen activator to fibrin.
Bilezikian et al. Unique pattern of fibrinogen cleavage by human leukocyte proteases
Heldebrant et al. The activation of prothrombin: I. Isolation and preliminary characterization of intermediates
Kisiel Molecular properties of the Factor V-activating enzyme from Russell's viper venom.
Moroz Mini-plasminogen: a mechanism for leukocyte modulation of plasminogen activation by urokinase
Van Der Graaf et al. Isolation and functional characterization of the active light chain of activated human blood coagulation factor XI.
Silverberg et al. The mechanism by which the light chain of cleaved HMW-kininogen augments the activation of prekallikrein, factor XI and Hageman factor
Wiman [32] Human α2-antiplasmin
Vali et al. Localization of the binding site on fibrin for the secondary binding site of thrombin
Rigbi et al. Limited proteolysis of the bovine pancreatic secretory trypsin inhibitor at acid pH
Movat The plasma kallikrein-kinin system and its interrelationship with other components of blood
Magnusson et al. Homologous “kringle” structures common to plasminogen and prothrombin. Substrate specificity of enzymes activating prothrombin and plasminogen
Reber et al. Three abnormal fibrinogen variants with the same amino acid substitution (γ 275 Arg→ His): Fibrinogens Bergamo II, Essen and Perugia