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Bedzhov et al., 2013 - Google Patents

Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency

Bedzhov et al., 2013

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Document ID
11050147842721037809
Author
Bedzhov I
Alotaibi H
Basilicata M
Ahlborn K
Liszewska E
Brabletz T
Stemmler M
Publication year
Publication venue
Stem cell research

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Embryonic stem (ES) cell pluripotency and induced pluripotent stem (iPS) cell generation is dependent on a core transcriptional network and proper cell–cell adhesion mediated by E- cadherin (E-cad). Whereas E-cad is associated with pluripotency, N-cadherin (N-cad) …
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • G—PHYSICS
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