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Kido et al., 1992 - Google Patents

Sequence-dependent cleavage of DNA by alkylation with antisense oligodeoxyribonucleotides containing a 2-(N-iodoacetylaminoethyl) thio-adenine

Kido et al., 1992

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Document ID
1125887345242196308
Author
Kido K
Inoue H
Ohtsuka E
Publication year
Publication venue
Nucleic acids research

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Abstract Antisense oligodeoxyribonucleotldes (15mers), containing a 2-(N- iodoacetylaminoethyl) thlo-adenine, were synthesized and tested for their ability to cleave complementary DNAs (21 mers). Cleavage of the target DNAs was done by alkylation …
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    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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