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Bernards et al., 1987 - Google Patents

Effective tumor immunotherapy directed against an oncogene-encoded product using a vaccinia virus vector.

Bernards et al., 1987

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Document ID
14411230660306710507
Author
Bernards R
Destree A
McKenzie S
Gordon E
Weinberg R
Panicali D
Publication year
Publication venue
Proceedings of the National Academy of Sciences

External Links

Snippet

We have constructed a vaccinia virus recombinant that expresses the extracellular domain of the rat neu oncogene-encoded protein, a 185-kDa transmembrane glycoprotein termed p185. Strain NFS mice immunized with this recombinant virus developed a strong antibody …
Continue reading at www.pnas.org (PDF) (other versions)

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
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