[go: up one dir, main page]

Goodson et al., 2015 - Google Patents

Hyperpolarization methods for MRS

Goodson et al., 2015

View PDF
Document ID
14983522237579496511
Author
Goodson B
Whiting N
Coffey A
Nikolaou P
Shi F
Gust B
Gemeinhardt M
Shchepin R
Skinner J
Birchall J
Barlow M
Chekmenev E
Publication year
Publication venue
Emagres

External Links

Continue reading at nottingham-repository.worktribe.com (PDF) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences, Generation or control of pulse sequences ; Operator Console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4804—Spatially selective measurement of temperature or pH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
    • G01R33/381—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using electromagnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance

Similar Documents

Publication Publication Date Title
Goodson et al. Hyperpolarization methods for MRS
Ardenkjaer-Larsen On the present and future of dissolution-DNP
Nikolaou et al. NMR hyperpolarization techniques for biomedicine
Hövener et al. Parahydrogen‐based hyperpolarization for biomedicine
US6574495B1 (en) Para-hydrogen labelled agents and their use in magnetic resonance imaging
JP5335780B2 (en) Highly sensitive NMR method for hyperpolarizable nuclei containing compounds, especially applying high sensitivity PHIP
Shi et al. Aqueous NMR signal enhancement by reversible exchange in a single step using water-soluble catalysts
US6574496B1 (en) Magnetic resonance imaging
Glöggler et al. Para-hydrogen perspectives in hyperpolarized NMR
Shchepin et al. Spin–lattice relaxation of hyperpolarized metronidazole in signal amplification by reversible exchange in micro-tesla fields
Chapman et al. Low-cost high-pressure clinical-scale 50% parahydrogen generator using liquid nitrogen at 77 K
Schmidt et al. Catalyst-free aqueous hyperpolarized [1-13C] pyruvate obtained by re-dissolution signal amplification by reversible exchange
EP2374016B1 (en) Pulse sequencing with hyperpolarisable nuclei
Rovedo et al. Molecular MRI in the Earth’s magnetic field using continuous hyperpolarization of a biomolecule in water
Chukanov et al. Synthesis of unsaturated precursors for parahydrogen-induced polarization and molecular imaging of 1-13C-acetates and 1-13C-pyruvates via side arm hydrogenation
Hune et al. Metabolic tumor imaging with rapidly signal‐enhanced 1‐13C‐pyruvate‐d3
Morozova et al. Light-induced spin hyperpolarisation in condensed phase
Stewart et al. Biomedical applications of the dynamic nuclear polarization and parahydrogen induced polarization techniques for hyperpolarized 13C MR imaging
Ariyasingha et al. Relaxation dynamics of nuclear long-lived spin states in propane and propane-d 6 hyperpolarized by parahydrogen
US20110050228A1 (en) agent for transporting nuclear spin order and for magnetic resonance imaging
Joalland et al. Scanning Nuclear Spin Level Anticrossings by Constant-Adiabaticity Magnetic Field Sweeping of Parahydrogen-Induced 13C Polarization
Schmidt Liquid-state nuclear hyperpolarization without a polarizer:: synthesis amid the magnet bore allows a dramatically enhanced nuclear alignment
Aime et al. Agents for polarization enhancement in MRI
Suh et al. The Chemistry of Hyperpolarized Magnetic Resonance Probes
Bondar Para-Hydrogen Hyperpolarization of metabolic substrates for Zero and Ultra-Low Field (ZULF) NMR detection