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Toujas et al., 2000 - Google Patents

Organometallic Additions to β-substituted N-Boc-β-aminoaldehydes: a New Synthesis of Enantiomerically Pure 1, 3-disubstituted N-Boc-1, 3-aminoalcohols

Toujas et al., 2000

Document ID
14998139360727402237
Author
Toujas J
Toupet L
Vaultier M
Publication year
Publication venue
Tetrahedron

External Links

Snippet

1, 2-addition of organolithium and organomagnesium derivatives to β-substituted (N-Boc)-β- aminoaldehydes gave access to enantiomerically pure, 1, 3-disubstituted, 1, 3- aminoalcohols. A diastereoselective version of this addition was also investigated and …
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C-Si linkages
    • C07F7/18—Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1812—Compounds having Si-O-C linkages having (C1)a-Si-(OC2)b linkages, a and b each being >=1 and a+b = 4, C1 and C2 being hydrocarbon or substituted hydrocarbon radicals
    • C07F7/1844—Compounds having Si-O-C linkages having (C1)a-Si-(OC2)b linkages, a and b each being >=1 and a+b = 4, C1 and C2 being hydrocarbon or substituted hydrocarbon radicals a being 3, b being 1
    • C07F7/1848—C1 being an unsubstituted acyclic saturated hydrocarbon radical containing less than six carbon atoms, a benzyl radical, a phenyl radical, or a methyl substituted phenyl radical
    • C07F7/1856—C2 containing cycloaliphatic, heterocyclic or condensed aromatic rings
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
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    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C-Si linkages
    • C07F7/12—Organo silicon halides
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    • C07D263/12—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals containing only hydrogen and carbon atoms

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