[go: up one dir, main page]

Bem et al., 2015 - Google Patents

Bacterial histidine kinases as novel antibacterial drug targets

Bem et al., 2015

View HTML @Full View
Document ID
17160696424660169627
Author
Bem A
Velikova N
Pellicer M
Baarlen P
Marina A
Wells J
Publication year
Publication venue
ACS chemical biology

External Links

Snippet

Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes including virulence, secretion systems and …
Continue reading at pubs.acs.org (HTML) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving viable micro-organisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Similar Documents

Publication Publication Date Title
Bem et al. Bacterial histidine kinases as novel antibacterial drug targets
Lakemeyer et al. Thinking outside the box—novel antibacterials to tackle the resistance crisis
Lade et al. Bacterial targets of antibiotics in methicillin-resistant Staphylococcus aureus
Crosby et al. The Staphylococcus aureus ArlRS two‐component system regulates virulence factor expression through MgrA
Sharkey et al. Antibiotic resistance ABC-F proteins: bringing target protection into the limelight
Gordon et al. Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective
Garland et al. Chemical strategies to target bacterial virulence
Miller et al. Mechanisms of antibiotic resistance in enterococci
Farha et al. Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams
Opperman et al. Recent advances toward a molecular mechanism of efflux pump inhibition
Koch et al. Evolution of resistance to a last-resort antibiotic in Staphylococcus aureus via bacterial competition
Lock et al. Cell-division inhibitors: new insights for future antibiotics
Sadykov et al. CcpA coordinates central metabolism and biofilm formation in Staphylococcus epidermidis
Velikova et al. Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens
Boibessot et al. The rational design, synthesis, and antimicrobial properties of thiophene derivatives that inhibit bacterial histidine kinases
Cutrona et al. From antihistamine to anti-infective: loratadine inhibition of regulatory PASTA kinases in staphylococci reduces biofilm formation and potentiates β-lactam antibiotics and vancomycin in resistant strains of Staphylococcus aureus
Han et al. Two distinct mechanisms of inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis
Chen et al. Recent advances in histidine kinase-targeted antimicrobial agents
Azad et al. Determining the mode of action of bioactive compounds
Guiberson et al. Spatially targeted proteomics of the host–pathogen interface during staphylococcal abscess formation
Wyche et al. Chemical genomics, structure elucidation, and in vivo studies of the marine-derived anticlostridial ecteinamycin
Burnside et al. Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence
Yadav et al. Moonlighting proteins: beacon of hope in era of drug resistance in bacteria
Silvestroni et al. Identification of serine/threonine kinase substrates in the human pathogen group B streptococcus
Davlieva et al. Two mutations commonly associated with daptomycin resistance in Enterococcus faecium LiaST120A and LiaRW73C appear to function epistatically in LiaFSR signaling