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Ohradanova-Repic et al., 2018 - Google Patents

Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances

Ohradanova-Repic et al., 2018

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Document ID
17645177575571420087
Author
Ohradanova-Repic A
Machacek C
Charvet C
Lager F
Le Roux D
Platzer R
Leksa V
Mitulovic G
Burkard T
Zlabinger G
Fischer M
Feuillet V
Renault G
Blüml S
Benko M
Suchanek M
Huppa J
Matsuyama T
Cavaco-Paulo A
Bismuth G
Stockinger H
Publication year
Publication venue
Frontiers in immunology

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Snippet

If misregulated, macrophage (Mϕ)–T cell interactions can drive chronic inflammation thereby causing diseases, such as rheumatoid arthritis (RA). We report that in a proinflammatory environment, granulocyte-Mϕ (GM-CSF)-and Mϕ colony-stimulating factor (M-CSF) …
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    • C12N5/0634Cells from the blood or the immune system
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    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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