Ohradanova-Repic et al., 2018 - Google Patents
Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalancesOhradanova-Repic et al., 2018
View HTML- Document ID
- 17645177575571420087
- Author
- Ohradanova-Repic A
- Machacek C
- Charvet C
- Lager F
- Le Roux D
- Platzer R
- Leksa V
- Mitulovic G
- Burkard T
- Zlabinger G
- Fischer M
- Feuillet V
- Renault G
- Blüml S
- Benko M
- Suchanek M
- Huppa J
- Matsuyama T
- Cavaco-Paulo A
- Bismuth G
- Stockinger H
- Publication year
- Publication venue
- Frontiers in immunology
External Links
Snippet
If misregulated, macrophage (Mϕ)–T cell interactions can drive chronic inflammation thereby causing diseases, such as rheumatoid arthritis (RA). We report that in a proinflammatory environment, granulocyte-Mϕ (GM-CSF)-and Mϕ colony-stimulating factor (M-CSF) …
- 210000002540 Macrophages 0 title abstract description 26
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ohradanova-Repic et al. | Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances | |
| Arroyo Hornero et al. | CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells | |
| Bridgewood et al. | IL-36γ is a strong inducer of IL-23 in psoriatic cells and activates angiogenesis | |
| Kleinman et al. | Regulatory T cells as potential targets for HIV cure research | |
| Grinberg-Bleyer et al. | NF-κB c-Rel is crucial for the regulatory T cell immune checkpoint in cancer | |
| Heink et al. | Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells | |
| Lamarthée et al. | Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction | |
| Li et al. | Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death | |
| Yan et al. | Sequential CD19 and BCMA‐specific CAR T‐cell treatment elicits sustained remission of relapsed and/or refractory myeloma | |
| Rissiek et al. | The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation | |
| Ni et al. | The effects of ketogenic diet on the Th17/Treg cells imbalance in patients with intractable childhood epilepsy | |
| Dhamne et al. | Peripheral and thymic foxp3+ regulatory T cells in search of origin, distinction, and function | |
| Fiore et al. | Induction of immunosuppressive functions and NF-κB by FLIP in monocytes | |
| Picarda et al. | Transient antibody targeting of CD45RC induces transplant tolerance and potent antigen-specific regulatory T cells | |
| Zhu et al. | Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer | |
| Sanctuary et al. | miR-106a deficiency attenuates inflammation in murine IBD models | |
| Kreiser et al. | Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo | |
| Dai et al. | Induction of T cell exhaustion by JAK1/3 inhibition in the treatment of alopecia areata | |
| Lelliott et al. | NKG7 enhances CD8+ T cell synapse efficiency to limit inflammation | |
| Talker et al. | Monocyte biology conserved across species: Functional insights from cattle | |
| Liang et al. | Distinct role of Tnfr1 and Tnfr2 in protective immunity against Orientia tsutsugamushi infection in mice | |
| Chandrasekaran et al. | Regulation of effector Treg cells in murine lupus | |
| Rao et al. | Acidity‐mediated induction of FoxP3+ regulatory T cells | |
| Zuo et al. | C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial | |
| Horwitz et al. | Anti-CD2 Antibody-coated nanoparticles containing IL-2 induce NK cells that protect lupus mice via a TGF-β-dependent mechanism |