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Kelley et al., 1985 - Google Patents

Mutational studies with the trp repressor of Escherichia coli support the helix-turn-helix model of repressor recognition of operator DNA.

Kelley et al., 1985

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Document ID
2092384561383832389
Author
Kelley R
Yanofsky C
Publication year
Publication venue
Proceedings of the National Academy of Sciences

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Several classes of trp repressor mutants were selected and analyzed in vivo. Mutants that produced repressors with either enhanced or reduced activity were obtained. One class of mutants produced inactive or slightly active repressors that were trans-dominant to the wild …
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