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Kitazume et al., 1986 - Google Patents

Synthesis of the optically pure monoethyl ester of (R)-(+)-2-fluoromalonic acid by use of immobilized lipase-my for asymmetric hydrolysis

Kitazume et al., 1986

Document ID
2618399600889270906
Author
Kitazume T
Murata K
Ikeya T
Publication year
Publication venue
Journal of fluorine chemistry

External Links

Snippet

A synthetic approach to optically pure (+)-2-fluoromalonic acid monoethyl ester was based on the enantiotopic specificity of asymmetric hydrolysis by an immobilized enzyme. The absolute configuration of monoethyl (+)-2-fluoromalonate was determined: it is the (R) …
Continue reading at www.sciencedirect.com (other versions)

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    • C12P41/00—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
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