Mountford et al., 2014 - Google Patents
Design, synthesis and evaluation of pyridine-based chromatographic adsorbents for antibody purificationMountford et al., 2014
- Document ID
- 353307573241240233
- Author
- Mountford S
- Daly R
- Robinson A
- Hearn M
- Publication year
- Publication venue
- Journal of Chromatography A
External Links
Snippet
The structure-based design and synthesis of four series of adsorbents for antibody purification by affinity chromatography has been investigated. The structures of 10 ligands were based on pyridine compounds that possessed thioalkyl substituents containing a …
- 239000003463 adsorbent 0 title abstract description 82
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Boschetti | The use of thiophilic chromatography for antibody purification: a review | |
| CN1926146B (en) | Antibody purification | |
| Roque et al. | Affinity-based methodologies and ligands for antibody purification: advances and perspectives | |
| RU2457214C2 (en) | Method for chromatography in weak distribution mode | |
| Mountford et al. | Design, synthesis and evaluation of pyridine-based chromatographic adsorbents for antibody purification | |
| Pinto et al. | Multimodal chromatography: debottlenecking the downstream processing of monoclonal antibodies | |
| EP3127916A1 (en) | Isolation of plasma or serum proteins | |
| JP2007525501A (en) | Antibody purification method | |
| WO2013158279A1 (en) | Protein purification methods to reduce acidic species | |
| Menegatti et al. | Purification of polyclonal antibodies from C ohn fraction II+ III, skim milk, and whey by affinity chromatography using a hexamer peptide ligand | |
| Fishman et al. | Antibody purification and storage | |
| Azevedo et al. | Downstream processing of human antibodies integrating an extraction capture step and cation exchange chromatography | |
| Zhang et al. | Purification of monoclonal antibodies by chemical affinity mixed mode chromatography | |
| Liu et al. | Affinity chromatographic purification of human immunoglobulin a from chinese hamster ovary cell culture supernatant | |
| Capela et al. | Monoclonal Antibodies Addressing the Challenges on the Manufacturing Processing of an Advanced Class of Therapeutic Agents | |
| Platis et al. | Affinity chromatography for the purification of therapeutic proteins from transgenic maize using immobilized histamine | |
| US20210380638A1 (en) | A method for improving aggregate removal by Protein A chromatography | |
| Lin et al. | Static and dynamic binding behavior of an IgG2 monoclonal antibody with several new mixed mode affinity adsorbents | |
| Mountford et al. | N‐Heterocyclic‐based adsorbents for antibody purification—effect of ligand structure | |
| Akhtar et al. | Evaluation of the Efficiency of Protein A Affinity Chromatography to Purify a Monoclonal Antibody for Cancer Treatment and its Purity Analysis | |
| Zhang et al. | Application of 4′-terpyridinylsulfanylethylamine resins for the purification of monoclonal antibodies by mixed-mode chromatography | |
| US20090264630A1 (en) | Method of separating monomeric protein(s) | |
| Chehraghi et al. | Purification of Monoclonal Antibodies Using Chromatographic Methods: Increasing Purity and Recovery | |
| Chu et al. | Purification of polyclonal immunoglobulin G from human serum using peptide‐based adsorbents | |
| Jafarzadeh Chehraghi et al. | Purification of Monoclonal Antibodies Using Chromatographic Methods: Increasing Purity and Recovery. |