[go: up one dir, main page]

MX2022013963A - Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas. - Google Patents

Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas.

Info

Publication number
MX2022013963A
MX2022013963A MX2022013963A MX2022013963A MX2022013963A MX 2022013963 A MX2022013963 A MX 2022013963A MX 2022013963 A MX2022013963 A MX 2022013963A MX 2022013963 A MX2022013963 A MX 2022013963A MX 2022013963 A MX2022013963 A MX 2022013963A
Authority
MX
Mexico
Prior art keywords
methods
adeno
associated virus
cross
species compatible
Prior art date
Application number
MX2022013963A
Other languages
English (en)
Inventor
Aravind Asokan
Trevor Gonzalez
Lawrence Patrick Havlik
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of MX2022013963A publication Critical patent/MX2022013963A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

La presente divulgación proporciona vectores de virus adenoasociados (AAV), que comprenden proteínas variantes de la cápside co-desarroladas, composiciones farmacéuticas, métodos de preparación, y métodos para administrarlas a un sujeto.
MX2022013963A 2020-05-05 2021-05-05 Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas. MX2022013963A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020062P 2020-05-05 2020-05-05
PCT/US2021/030937 WO2021226267A2 (en) 2020-05-05 2021-05-05 Cross-species compatible adeno-associated virus compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2022013963A true MX2022013963A (es) 2023-02-22

Family

ID=78468375

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022013963A MX2022013963A (es) 2020-05-05 2021-05-05 Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas.

Country Status (13)

Country Link
US (3) US20230151389A1 (es)
EP (1) EP4125977A4 (es)
JP (1) JP2023524291A (es)
KR (1) KR20230029616A (es)
CN (1) CN116096377A (es)
AR (1) AR122013A1 (es)
AU (1) AU2021268946A1 (es)
BR (1) BR112022022644A2 (es)
CA (1) CA3177869A1 (es)
IL (1) IL297577A (es)
MX (1) MX2022013963A (es)
TW (1) TW202208631A (es)
WO (1) WO2021226267A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116096377A (zh) * 2020-05-05 2023-05-09 杜克大学 跨物种相容的腺相关病毒组合物及其使用方法
IL311871A (en) 2021-10-08 2024-06-01 Dyno Therapeutics Inc Capsid variants and methods of using them
EP4577663A2 (en) * 2022-08-24 2025-07-02 RegenxBio Inc. Recombinant adeno-associated viruses and uses thereof
WO2024168089A2 (en) * 2023-02-07 2024-08-15 Duke University Compositions comprising aavs and methods for treating gastrointestinal diseases
TW202434734A (zh) * 2023-02-08 2024-09-01 美商銀杏生物工作室有限公司 天使症候群的基因療法
WO2024191778A1 (en) 2023-03-10 2024-09-19 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2024206831A1 (en) * 2023-03-31 2024-10-03 Duke University Compositions comprising brain-tropic aavs and methods of use thereof
WO2025049993A1 (en) 2023-08-31 2025-03-06 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof
WO2025171227A1 (en) 2024-02-08 2025-08-14 Dyno Therapeutics, Inc. Capsid polypeptides and methods of use thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478745A (en) 1992-12-04 1995-12-26 University Of Pittsburgh Recombinant viral vector system
DE69941905D1 (de) 1998-11-10 2010-02-25 Univ North Carolina Virusvektoren und verfahren für ihre herstellung und verabreichung.
US7314912B1 (en) 1999-06-21 2008-01-01 Medigene Aktiengesellschaft AAv scleroprotein, production and use thereof
AU2001269723B9 (en) 2000-06-01 2006-11-16 University Of North Carolina At Chapel Hill Duplexed parvovirus vectors
CN102174574B (zh) * 2003-09-30 2016-08-03 宾夕法尼亚大学托管会 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用
US9198984B2 (en) * 2006-04-28 2015-12-01 The Trustees Of The University Of Pennsylvania Scalable production method for AAV
US8734809B2 (en) 2009-05-28 2014-05-27 University Of Massachusetts AAV's and uses thereof
WO2012109570A1 (en) * 2011-02-10 2012-08-16 The University Of North Carolina At Chapel Hill Viral vectors with modified transduction profiles and methods of making and using the same
ES2897508T3 (es) * 2013-05-31 2022-03-01 Univ California Variantes de virus adenoasociados y métodos de uso de las mismas
US10746742B2 (en) * 2014-04-25 2020-08-18 Oregon Health & Science University Methods of viral neutralizing antibody epitope mapping
WO2015191508A1 (en) * 2014-06-09 2015-12-17 Voyager Therapeutics, Inc. Chimeric capsids
PT3356390T (pt) 2015-09-28 2021-04-21 Univ Florida Métodos e composições para vetores virais que se evadem a anticorpos
US11905312B2 (en) * 2017-02-15 2024-02-20 The University Of North Carolina At Chapel Hill Methods and compositions for gene transfer across the vasculature
US20210130413A1 (en) * 2017-02-28 2021-05-06 Adverum Biotechnologies, Inc. Modified aav capsids and uses thereof
JP7132934B2 (ja) * 2017-03-15 2022-09-07 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル ポリプロイド性アデノ随伴ウイルスベクターならびにその作製および使用の方法
US10550405B2 (en) 2017-03-15 2020-02-04 The University Of North Carolina At Chapel Hill Rational polyploid adeno-associated virus vectors and methods of making and using the same
EP3773743A1 (en) * 2018-04-03 2021-02-17 Stridebio, Inc. Virus vectors for targeting ophthalmic tissues
MX2020010466A (es) 2018-04-03 2021-01-08 Vectores de virus que evitan anticuerpos.
WO2019222444A2 (en) 2018-05-16 2019-11-21 Voyager Therapeutics, Inc. Directed evolution
AU2019351815A1 (en) * 2018-10-01 2021-05-06 The Trustees Of The University Of Pennsylvania Compositions useful for treating GM1 gangliosidosis
MX2021011468A (es) 2019-03-21 2021-12-15 Vectores de virus adenoasociados recombinantes.
CN116096377A (zh) * 2020-05-05 2023-05-09 杜克大学 跨物种相容的腺相关病毒组合物及其使用方法

Also Published As

Publication number Publication date
BR112022022644A2 (pt) 2023-01-17
EP4125977A4 (en) 2024-09-25
IL297577A (en) 2022-12-01
CN116096377A (zh) 2023-05-09
TW202208631A (zh) 2022-03-01
EP4125977A2 (en) 2023-02-08
KR20230029616A (ko) 2023-03-03
US12037598B2 (en) 2024-07-16
US20240076695A1 (en) 2024-03-07
US12146151B2 (en) 2024-11-19
CA3177869A1 (en) 2021-11-11
AU2021268946A1 (en) 2022-12-01
JP2023524291A (ja) 2023-06-09
US20240067988A1 (en) 2024-02-29
WO2021226267A2 (en) 2021-11-11
WO2021226267A3 (en) 2021-12-16
US20230151389A1 (en) 2023-05-18
AR122013A1 (es) 2022-08-03

Similar Documents

Publication Publication Date Title
MX2022013963A (es) Composiciones de virus adenoasociados compatibles entre especies y metodos de uso de las mismas.
PH12020551938A1 (en) Liver targeting adeno-associated viral vectors
PH12018500594A1 (en) Adeno-associated virus factor viii vectors, associated viral particles and therapeutic formulations comprising the same
PH12019500068A1 (en) Novel adeno-associated virus capsid proteins
EA202091712A1 (ru) МОДИФИЦИРОВАННЫЙ КАПСИДНЫЙ БЕЛОК rAAV ДЛЯ ГЕННОЙ ТЕРАПИИ
MX388331B (es) Variantes de virus adenoasociado y métodos de uso de estas
PH12020550094A1 (en) Adeno-associated virus variant capsids and methods of use thereof
MX2024012403A (es) Novedoso vector del subtipo f del virus adenoasociado (aav) y usos de este
MX2022014256A (es) Redirección del tropismo de las cápsides de aav.
MX2020005451A (es) Capsides variantes de virus adenoasociados y uso para inhibir la angiogenesis.
UA124343C2 (uk) Капсиди аденоасоційованого вірусу і спосіб його використання
AU2018298422A1 (en) Novel nucleic acid molecules
BR112021020957A2 (pt) Capsídeos de vírus adenoassociado (aav) variante para liberação intravítrea
WO2017058892A3 (en) Methods and compositions for antibody-evading virus vectors
MX2019012223A (es) Anticuerpos anti-cd137 y metodos de uso de los mismos.
WO2019210267A3 (en) Engineered aav capsids with increased tropism and aav vectors comprising the engineered capsids and methods of making and using same
MX2024009660A (es) Variantes de capside de aav y usos de las mismas.
MX389111B (es) Vectores virales recombinantes que contienen la proteina menor del virus del sindrome reproductor y respiratorio porcino (prrsv) y sus metodos de elaboracion y uso.
PH12021550705A1 (en) Stable semaglutide compositions and uses thereof
MX2020002148A (es) Vectores adenoasociados recombinantes.
MX2019008105A (es) Virus.
MX2022004944A (es) Composiciones y metodos para minimizar la perdida de proteinas a concentraciones de proteinas bajas.
NZ756125A (en) Methods for determining potency of adeno-associated virus preparations
WO2023004407A3 (en) Adeno-associated virus compositions and methods of use thereof
MX390927B (es) Partículas semejantes a virus recombinantes que utilizan la proteína gag del virus de inmunodeficiencia bovina.