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MXPA03006666A - Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. - Google Patents

Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso.

Info

Publication number
MXPA03006666A
MXPA03006666A MXPA03006666A MXPA03006666A MXPA03006666A MX PA03006666 A MXPA03006666 A MX PA03006666A MX PA03006666 A MXPA03006666 A MX PA03006666A MX PA03006666 A MXPA03006666 A MX PA03006666A MX PA03006666 A MXPA03006666 A MX PA03006666A
Authority
MX
Mexico
Prior art keywords
compounds
binding compounds
cyclophilin binding
cyp
cyclophilin
Prior art date
Application number
MXPA03006666A
Other languages
English (en)
Inventor
Hamilton Gregory
Original Assignee
Guilford Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc filed Critical Guilford Pharm Inc
Publication of MXPA03006666A publication Critical patent/MXPA03006666A/es

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
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Abstract

La presente invencion se refiere a novedosos compuestos organicos pequenos, no peptidicos, que tienen una afinidad por proteinas de inmunofilina tipo ciclofilina (CyP) y a composiciones farmaceuticas que comprenden uno o mas de dichos compuestos. La invencion se refiere ademas a los usos de estos compuestos y composiciones para unir proteinas tipo CyP, inhibir su actividad de peptidil-prolil isomerasa, y para investigacion, desarrollo y aplicaciones terapeuticas en una variedad de desordenes medicos.
MXPA03006666A 2001-01-25 2002-01-25 Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. MXPA03006666A (es)

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PCT/US2002/002538 WO2002059080A2 (en) 2001-01-25 2002-01-25 Trisubstituted carbocyclic cyclophilin binding compounds and their use

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US6656971B2 (en) 2003-12-02
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