NL1031845A1 - Pyrimidine derivatives for the treatment of abnormal cell growth. - Google Patents

Pyrimidine derivatives for the treatment of abnormal cell growth.

Info

Publication number: NL1031845A1
Authority: NL; Netherlands
Prior art keywords: treatment; cell growth; abnormal cell; pyrimidine derivatives; pyrimidine
Prior art date: 2004-05-14

Application number

NL1031845A

Other languages

Dutch (nl)

Other versions

NL1031845C2 (en

Inventor

Michael Joseph Luzzio

John Charles Kath

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-14

Filing date

2006-05-19

Publication date

2006-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34966230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL1031845(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-05-19 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2006-07-31 Publication of NL1031845A1 publication Critical patent/NL1031845A1/en

2006-11-23 Application granted granted Critical

2006-11-23 Publication of NL1031845C2 publication Critical patent/NL1031845C2/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NL1031845A 2004-05-14 2006-05-19 Pyrimidine derivatives for the treatment of abnormal cell growth. NL1031845C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57131204P	2004-05-14	2004-05-14
US57131204		2004-05-14

Publications (2)

Publication Number	Publication Date
NL1031845A1 true NL1031845A1 (en)	2006-07-31
NL1031845C2 NL1031845C2 (en)	2006-11-23

Family

ID=34966230

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NL1029045A NL1029045C2 (en)	2004-05-14	2005-05-13	Pyrimidine derivatives for the treatment of abnormal cell growth.
NL1031845A NL1031845C2 (en)	2004-05-14	2006-05-19	Pyrimidine derivatives for the treatment of abnormal cell growth.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NL1029045A NL1029045C2 (en)	2004-05-14	2005-05-13	Pyrimidine derivatives for the treatment of abnormal cell growth.

Country Status (27)

Country	Link
EP (1)	EP1751143A1 (en)
JP (1)	JP4099212B2 (en)
KR (1)	KR100886990B1 (en)
CN (2)	CN102127058A (en)
AP (1)	AP2241A (en)
AR (1)	AR049097A1 (en)
AU (2)	AU2005243397A1 (en)
BR (1)	BRPI0511138A (en)
CA (1)	CA2566707A1 (en)
CR (1)	CR8749A (en)
EA (1)	EA200601796A1 (en)
EC (1)	ECSP066997A (en)
GE (1)	GEP20104875B (en)
GT (1)	GT200500113A (en)
IL (1)	IL178828A0 (en)
MA (1)	MA28583B1 (en)
MX (1)	MXPA06011890A (en)
NL (2)	NL1029045C2 (en)
NO (1)	NO20064576L (en)
NZ (1)	NZ550448A (en)
PA (1)	PA8632601A1 (en)
PE (1)	PE20060240A1 (en)
TN (1)	TNSN06370A1 (en)
TW (1)	TWI303635B (en)
UY (1)	UY28894A1 (en)
WO (1)	WO2005111023A1 (en)
ZA (1)	ZA200608394B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005118544A2 (en) *	2004-05-18	2005-12-15	Rigel Pharmaceuticals, Inc.	Cycloalkyl substituted pyrimidinediamine compounds and their uses
US20070032514A1 (en) *	2005-07-01	2007-02-08	Zahn Stephan K	2,4-diamino-pyrimidines as aurora inhibitors
CN101346380B (en) *	2005-12-21	2012-02-29	辉瑞产品公司	Pyrimidine derivatives for the treatment of abnormal cell growth
CN103951658B (en) *	2007-04-18	2017-10-13	辉瑞产品公司	Sulfamide derivative for treating abnormal cell growth
JP5586460B2 (en) *	2007-07-17	2014-09-10	ライジェルファーマシューティカルズ，インコーポレイテッド	Cyclic amine-substituted pyrimidinediamines as PKC inhibitors
CA2707653A1 (en) *	2007-12-03	2009-06-11	Boehringer Ingelheim International Gmbh	Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
LT2300013T (en) *	2008-05-21	2017-12-27	Ariad Pharmaceuticals, Inc.	Phosphorous derivatives as kinase inhibitors
US8410126B2 (en) *	2009-05-29	2013-04-02	Boehringer Ingelheim International Gmbh	Pyrimidine inhibitors of PKTK2
US8933227B2 (en)	2009-08-14	2015-01-13	Boehringer Ingelheim International Gmbh	Selective synthesis of functionalized pyrimidines
WO2011018517A1 (en)	2009-08-14	2011-02-17	Boehringer Ingelheim International Gmbh	Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
US20120244141A1 (en)	2010-09-28	2012-09-27	Boehringer Ingelheim International Gmbh	Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors
JPWO2014174745A1 (en) *	2013-04-26	2017-02-23	国立大学法人京都大学	Eg5 inhibitor
CN109608444B (en) *	2018-11-27	2022-02-11	中国药科大学	ERK inhibitor containing isoindolinone and preparation method and use thereof
CN111732548B (en) *	2020-06-11	2022-06-17	浙江大学	N2-carbamyl aromatic ring-2-aminopyrimidine derivatives and medical application thereof
WO2024140671A1 (en) *	2022-12-29	2024-07-04	南京昕瑞再生医药科技有限公司	Fused tricyclic derivative, pharmaceutical composition comprising same, and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9721437D0 (en) *	1997-10-10	1997-12-10	Glaxo Group Ltd	Heteroaromatic compounds and their use in medicine
AR042586A1 (en)	2001-02-15	2005-06-29	Sugen Inc	3- (4-AMIDOPIRROL-2-ILMETILIDEN) -2-INDOLINONE AS INHIBITORS OF PROTEIN KINASE; YOUR PHARMACEUTICAL COMPOSITIONS; A METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF PROTEINQUINASE; A METHOD TO TREAT OR PREVENT AN AFFECTION RELATED TO PROTEINQUINASE
WO2003030909A1 (en) *	2001-09-25	2003-04-17	Bayer Pharmaceuticals Corporation	2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer
ES2338545T3 (en) *	2002-12-20	2010-05-10	Pfizer Products Inc.	PIRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELLULAR GROWTH.
UA80767C2 (en) *	2002-12-20	2007-10-25	Pfizer Prod Inc	Pyrimidine derivatives for the treatment of abnormal cell growth

2005
- 2005-05-02 EP EP05732043A patent/EP1751143A1/en not_active Withdrawn
- 2005-05-02 NZ NZ550448A patent/NZ550448A/en not_active IP Right Cessation
- 2005-05-02 AP AP2006003790A patent/AP2241A/en active
- 2005-05-02 MX MXPA06011890A patent/MXPA06011890A/en unknown
- 2005-05-02 EA EA200601796A patent/EA200601796A1/en unknown
- 2005-05-02 WO PCT/IB2005/001201 patent/WO2005111023A1/en active Application Filing
- 2005-05-02 CN CN2011100212904A patent/CN102127058A/en active Pending
- 2005-05-02 CA CA002566707A patent/CA2566707A1/en not_active Abandoned
- 2005-05-02 JP JP2007512557A patent/JP4099212B2/en not_active Expired - Lifetime
- 2005-05-02 GE GEAP20059703A patent/GEP20104875B/en unknown
- 2005-05-02 BR BRPI0511138-2A patent/BRPI0511138A/en not_active IP Right Cessation
- 2005-05-02 KR KR1020067023767A patent/KR100886990B1/en not_active Expired - Lifetime
- 2005-05-02 AU AU2005243397A patent/AU2005243397A1/en not_active Abandoned
- 2005-05-02 CN CNA2005800155302A patent/CN1953974A/en active Pending
- 2005-05-11 TW TW094115237A patent/TWI303635B/en not_active IP Right Cessation
- 2005-05-11 PA PA20058632601A patent/PA8632601A1/en unknown
- 2005-05-12 PE PE2005000534A patent/PE20060240A1/en not_active Application Discontinuation
- 2005-05-12 UY UY28894A patent/UY28894A1/en not_active Application Discontinuation
- 2005-05-13 GT GT200500113A patent/GT200500113A/en unknown
- 2005-05-13 NL NL1029045A patent/NL1029045C2/en not_active IP Right Cessation
- 2005-05-13 AR ARP050101969A patent/AR049097A1/en not_active Application Discontinuation
2006
- 2006-05-19 NL NL1031845A patent/NL1031845C2/en not_active IP Right Cessation
- 2006-10-06 ZA ZA200608394A patent/ZA200608394B/en unknown
- 2006-10-09 NO NO20064576A patent/NO20064576L/en not_active Application Discontinuation
- 2006-10-23 IL IL178828A patent/IL178828A0/en unknown
- 2006-11-13 EC EC2006006997A patent/ECSP066997A/en unknown
- 2006-11-13 TN TNP2006000370A patent/TNSN06370A1/en unknown
- 2006-11-13 CR CR8749A patent/CR8749A/en not_active Application Discontinuation
- 2006-11-14 MA MA29452A patent/MA28583B1/en unknown
2009
- 2009-11-13 AU AU2009238255A patent/AU2009238255A1/en not_active Ceased

Also Published As

Publication number	Publication date
AR049097A1 (en)	2006-06-28
ECSP066997A (en)	2007-02-28
ZA200608394B (en)	2008-05-28
CA2566707A1 (en)	2005-11-24
MXPA06011890A (en)	2006-12-14
NL1031845C2 (en)	2006-11-23
KR100886990B1 (en)	2009-03-04
WO2005111023A1 (en)	2005-11-24
UY28894A1 (en)	2005-12-30
KR20070012477A (en)	2007-01-25
EA200601796A1 (en)	2007-04-27
AU2009238255A1 (en)	2009-12-03
TWI303635B (en)	2008-12-01
BRPI0511138A (en)	2007-11-27
AP2006003790A0 (en)	2006-10-31
AP2241A (en)	2011-06-01
JP2007537234A (en)	2007-12-20
NZ550448A (en)	2010-11-26
JP4099212B2 (en)	2008-06-11
PE20060240A1 (en)	2006-04-01
CN102127058A (en)	2011-07-20
NL1029045C2 (en)	2006-06-02
CN1953974A (en)	2007-04-25
TNSN06370A1 (en)	2008-02-22
TW200539871A (en)	2005-12-16
PA8632601A1 (en)	2006-06-02
CR8749A (en)	2006-12-05
MA28583B1 (en)	2007-05-02
GT200500113A (en)	2006-01-10
GEP20104875B (en)	2010-01-11
NO20064576L (en)	2006-11-07
AU2005243397A1 (en)	2005-11-24
EP1751143A1 (en)	2007-02-14
NL1029045A1 (en)	2005-11-15
IL178828A0 (en)	2007-03-08

Publication	Publication Date	Title
NL2000375A1 (en)	2007-06-25	Pyrimidine derivatives for the treatment of abnormal cell growth.
NL1031845A1 (en)	2006-07-31	Pyrimidine derivatives for the treatment of abnormal cell growth.
NL1025067A1 (en)	2004-06-22	Pyrimidine derivatives for the treatment of abnormal cell growth.
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DK1633726T3 (en)	2011-03-28	Pyrimidine derivatives suitable for the treatment of CRTH2-mediated diseases
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NL2000323A1 (en)	2007-06-21	Pyrimidine derivatives.
NL1026327A1 (en)	2004-12-07	2-Amino-pyridine derivatives useful for the treatment of diseases.
SI1869056T1 (en)	2011-02-28	Novel 5-substituted 7-amino-y1,3 thiazoloy4,5-d pyrimidine derivatives
NL1026203A1 (en)	2004-11-16	Compounds useful for the treatment of diseases.
EP1720863A4 (en)	2009-04-22	Heteroarylaminopyrazole derivatives useful for the treatment of diabetes
DE602006003094D1 (en)	2008-11-20	4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROCHINOLINE DERIVATIVES FOR THE TREATMENT OF BARRENESS
NL1033562A1 (en)	2007-06-21	Tetrahydropyridoazepine-8-ones and related compounds for the treatment of schizophrenia.
NL1028599A1 (en)	2005-09-26	Compounds for the treatment of diseases.
WO2006081337A3 (en)	2007-02-15	Erastin analogues and their uses for killing cancer cells
NL1025044A1 (en)	2004-06-21	Bicyclic derivatives for the treatment of abnormal cell growth.
NL1032552C2 (en)	2007-09-25	Imidazole compounds for the treatment of neurological disorders.
FR2873372B1 (en)	2006-09-08	PROCESS FOR THE PREPARATION OF N-PIPERIDINO-1,5-DIPHENYLPYRAZOLE-3-CARBOXAMIDE DERIVATIVES
WO2007060458A3 (en)	2008-01-10	Treatment of ophthalmic diseases with beta-amino alcohols
NL2000255A1 (en)	2007-04-11	Inhibitors of the HIV integrase enzyme.

Legal Events

Date	Code	Title	Description
2006-10-02	AD1A	A request for search or an international type search has been filed
2007-01-02	PD2A	A request for search or an international type search has been filed
2025-05-14	MK	Patent expired because of reaching the maximum lifetime of a patent	Effective date: 20250512