NO175978C - Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-aza-bicykliske forbindelser - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-aza-bicykliske forbindelser

Info

Publication number: NO175978C
Authority: NO; Norway
Prior art keywords: aza; preparation; therapeutically active; bicyclic compounds; analogous process
Prior art date: 1989-01-23

Application number

NO912863A

Other languages

English (en)

Norwegian (no)

Other versions

NO912863D0 (no

NO912863L (no

NO175978B (no

Inventor

Gene Michael Bright

Kishor A Desai

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-23

Filing date

1991-07-22

Publication date

1995-01-11

1991-07-22 Application filed by Pfizer filed Critical Pfizer

1991-07-22 Publication of NO912863D0 publication Critical patent/NO912863D0/no

1991-07-22 Publication of NO912863L publication Critical patent/NO912863L/no

1994-10-03 Publication of NO175978B publication Critical patent/NO175978B/no

1995-01-11 Publication of NO175978C publication Critical patent/NO175978C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

NO912863A 1989-01-23 1991-07-22 Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-aza-bicykliske forbindelser NO175978C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1989/000275 WO1990008148A1 (fr)	1989-01-23	1989-01-23	Agents anxiolytiques bis-aza-bicycliques
PCT/US1989/003811 WO1990008144A1 (fr)	1989-01-23	1989-09-01	Agents anxiolytiques bis-aza-bicycliques

Publications (4)

Publication Number	Publication Date
NO912863D0 NO912863D0 (no)	1991-07-22
NO912863L NO912863L (no)	1991-07-22
NO175978B NO175978B (no)	1994-10-03
NO175978C true NO175978C (no)	1995-01-11

Family

ID=22214801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO912863A NO175978C (no)	1989-01-23	1991-07-22	Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-aza-bicykliske forbindelser

Country Status (38)

Country	Link
US (1)	US5122525A (fr)
EP (1)	EP0380217B1 (fr)
JP (1)	JPH0643427B2 (fr)
KR (1)	KR910009289B1 (fr)
CN (1)	CN1022186C (fr)
AP (1)	AP128A (fr)
AR (1)	AR246969A1 (fr)
AT (1)	ATE82574T1 (fr)
AU (1)	AU614214B2 (fr)
BA (1)	BA98302A (fr)
BG (1)	BG51046A3 (fr)
CA (1)	CA2008108C (fr)
CZ (1)	CZ277698B6 (fr)
DD (1)	DD291560A5 (fr)
DE (1)	DE69000467T2 (fr)
DK (1)	DK0380217T3 (fr)
EG (1)	EG19306A (fr)
ES (1)	ES2053094T3 (fr)
FI (1)	FI95381C (fr)
GR (1)	GR3006925T3 (fr)
HU (1)	HU215154B (fr)
IE (1)	IE62670B1 (fr)
IL (1)	IL93073A (fr)
IS (1)	IS1667B (fr)
MA (1)	MA21735A1 (fr)
MX (1)	MX19222A (fr)
MY (1)	MY104861A (fr)
NO (1)	NO175978C (fr)
NZ (1)	NZ232168A (fr)
OA (1)	OA10041A (fr)
PL (1)	PL163836B1 (fr)
PT (1)	PT92919B (fr)
RO (1)	RO110142B1 (fr)
RU (1)	RU2015977C1 (fr)
SK (1)	SK279339B6 (fr)
WO (2)	WO1990008148A1 (fr)
YU (1)	YU47554B (fr)
ZA (1)	ZA90430B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos
WO1992000075A1 (fr) *	1990-06-29	1992-01-09	Pfizer Inc.	Derives de pyridopyrazine utilises dans le traitement de l'abus et de la dependance de substances
WO1992013858A1 (fr) *	1991-01-31	1992-08-20	Pfizer Inc.	Decomposition de trans-2-(2-pyrimidinyle)-7-(hydroxymethyle)octahydro-2h-pyrido[1,2-a]pyrazine
CA2101252C (fr) *	1991-02-27	1998-02-17	Frank J. Urban	Methode de preparation de trans-piperidine-2,5-dicarboxylates
US5185449A (en) *	1991-02-27	1993-02-09	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5157034A (en) *	1991-02-27	1992-10-20	Pfizer Inc.	Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5311195A (en) *	1991-08-30	1994-05-10	Etak, Inc.	Combined relative and absolute positioning method and apparatus
FI941377A0 (fi) *	1991-09-25	1994-03-24	Pfizer	Neuroleptisiä 2-substituoituja perhydro-1-H-pyrido/1,2-a/-pyratsiineja
CA2138018C (fr) *	1992-06-16	1998-01-27	Frank J. Urban	Procede et intermediaires pour agents anxiolytiques bi-aza-bicycliques
AU5291793A (en) *	1992-09-24	1994-04-12	National Institutes Of Health	Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) *	1993-01-25	1997-11-20	Israel State	Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) *	1993-08-20	1997-06-10	Pfizer Inc.	Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) *	1993-10-13	1995-10-03	Pfizer Inc.	Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) *	1993-11-01	1999-06-20	Israel State	Controlled cryogenic contact system
US5731307A (en) *	1994-09-30	1998-03-24	Pfizer, Inc.	Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
US5852031A (en) *	1994-09-30	1998-12-22	Pfizer Inc.	2,7-substituted octahydro-1H-pyrido 1,2-a!pyrazine derivatives
US6231833B1 (en)	1999-08-05	2001-05-15	Pfizer Inc	2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
IL124453A0 (en) *	1995-12-21	1998-12-06	Pfizer	2,7-substituted octahydro-pyrrolo [1,2-A]pyrazine derivatives
CN1221418A (zh) *	1996-07-01	1999-06-30	辉瑞大药厂	(7s,反)－2－(2－嘧啶基)－7－(羟甲基)八氢－2h－吡啶并[1,2－a)吡嗪的制备
PA8469101A1 (es) *	1998-04-09	2000-09-29	Pfizer Prod Inc	Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) *	1998-09-21	2000-11-11	Pfizer Prod Inc	Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) *	2000-07-31	2002-02-07	Coe Jotham Wadsworth	Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en)	2000-11-29	2003-12-30	Pfizer Inc.	Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
EP1608648B1 (fr) *	2003-03-12	2012-07-18	Pfizer Products Inc.	Derives azabicycliques de pyridyloxymethyl et de benzisoxazole
US7834014B2 (en)	2003-04-09	2010-11-16	Biogen Idec Ma Inc.	A2a adenosine receptor antagonists
WO2005051919A1 (fr) *	2003-11-26	2005-06-09	Pfizer Products Inc.	Derives d'aminopyrazole en tant qu'inhibiteurs de la gsk-3
US20070219201A1 (en) *	2004-05-27	2007-09-20	Warner-Lambert Company Llc	Combination of atomoxetine and a 5ht1a receptor agonist for treating adhd and other disorders
US7658206B2 (en)	2006-12-05	2010-02-09	Kohler Co.	Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3388128A (en) *	1965-09-03	1968-06-11	Allan R. Day	Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) *	1978-05-22	1980-01-08	Mead Johnson & Company	Buspirone anti-anxiety method
US4339579A (en) *	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) *	1982-05-07	1983-08-23	American Home Products Corporation	2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) *	1982-05-25	1983-11-08	American Home Products Corporation	4-Substituted-piperidino carboxamides
US4517187A (en) *	1982-10-18	1985-05-14	Pennwalt Corporation	1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) *	1983-06-18	1984-12-20	Troponwerke GmbH & Co KG, 5000 Köln	2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) *	1984-03-15	1985-09-26	Bayer Ag, 5090 Leverkusen	Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) *	1986-02-17	1989-03-10	Acraf	Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
JP2668259B2 (ja) *	1988-02-18	1997-10-27	塩野義製薬株式会社	複素環化合物および抗潰瘍剤
MX19222A (es) *	1989-01-23	1993-12-01	Pfizer	Agentes ansioliticos bis-aza-biciclicos

1989
- 1989-01-23 MX MX1922290A patent/MX19222A/es unknown
- 1989-01-23 WO PCT/US1989/000275 patent/WO1990008148A1/fr unknown
- 1989-09-01 HU HU40/90A patent/HU215154B/hu not_active IP Right Cessation
- 1989-09-01 WO PCT/US1989/003811 patent/WO1990008144A1/fr active IP Right Grant
- 1989-09-01 RO RO148053A patent/RO110142B1/ro unknown
- 1989-12-13 IS IS3529A patent/IS1667B/is unknown
1990
- 1990-01-12 DE DE9090300362T patent/DE69000467T2/de not_active Expired - Fee Related
- 1990-01-12 AT AT90300362T patent/ATE82574T1/de not_active IP Right Cessation
- 1990-01-12 EP EP90300362A patent/EP0380217B1/fr not_active Expired - Lifetime
- 1990-01-12 ES ES90300362T patent/ES2053094T3/es not_active Expired - Lifetime
- 1990-01-12 DK DK90300362.2T patent/DK0380217T3/da active
- 1990-01-16 IL IL9307390A patent/IL93073A/en not_active IP Right Cessation
- 1990-01-18 BG BG090949A patent/BG51046A3/bg unknown
- 1990-01-19 MY MYPI90000101A patent/MY104861A/en unknown
- 1990-01-19 NZ NZ232168A patent/NZ232168A/xx unknown
- 1990-01-19 AR AR90315971A patent/AR246969A1/es active
- 1990-01-19 CA CA002008108A patent/CA2008108C/fr not_active Expired - Fee Related
- 1990-01-21 EG EG3290A patent/EG19306A/xx active
- 1990-01-22 SK SK299-90A patent/SK279339B6/sk unknown
- 1990-01-22 CN CN90100291A patent/CN1022186C/zh not_active Expired - Fee Related
- 1990-01-22 AP APAP/P/1990/000158A patent/AP128A/en active
- 1990-01-22 PT PT92919A patent/PT92919B/pt not_active IP Right Cessation
- 1990-01-22 KR KR1019900000701A patent/KR910009289B1/ko not_active Expired
- 1990-01-22 MA MA21996A patent/MA21735A1/fr unknown
- 1990-01-22 PL PL90283395A patent/PL163836B1/pl not_active IP Right Cessation
- 1990-01-22 YU YU11190A patent/YU47554B/sh unknown
- 1990-01-22 DD DD90337249A patent/DD291560A5/de not_active IP Right Cessation
- 1990-01-22 IE IE22590A patent/IE62670B1/en not_active IP Right Cessation
- 1990-01-22 CZ CS90299A patent/CZ277698B6/cs not_active IP Right Cessation
- 1990-01-22 ZA ZA90430A patent/ZA90430B/xx unknown
- 1990-01-22 AU AU48679/90A patent/AU614214B2/en not_active Ceased
- 1990-01-23 JP JP2013459A patent/JPH0643427B2/ja not_active Expired - Fee Related
- 1990-01-23 OA OA59727A patent/OA10041A/en unknown
1991
- 1991-07-09 US US07/721,537 patent/US5122525A/en not_active Expired - Lifetime
- 1991-07-22 NO NO912863A patent/NO175978C/no unknown
- 1991-07-22 RU SU915001279A patent/RU2015977C1/ru not_active IP Right Cessation
- 1991-07-22 FI FI913510A patent/FI95381C/fi not_active IP Right Cessation
1993
- 1993-01-28 GR GR930400172T patent/GR3006925T3/el unknown
1998
- 1998-03-30 BA BA980302A patent/BA98302A/bs unknown

Also Published As

Publication number	Publication date
ES2053094T3 (es)	1994-07-16
NO912863D0 (no)	1991-07-22
CN1022186C (zh)	1993-09-22
BA98302A (bs)	2001-09-14
IE900225L (en)	1990-07-23
EP0380217A1 (fr)	1990-08-01
AU4867990A (en)	1990-07-26
ZA90430B (en)	1991-08-28
DE69000467T2 (de)	1993-04-01
PL163836B1 (pl)	1994-05-31
CZ277698B6 (en)	1993-03-17
BG51046A3 (bg)	1993-01-15
AP9000158A0 (en)	1990-01-31
US5122525A (en)	1992-06-16
KR910009289B1 (ko)	1991-11-09
FI913510A0 (fi)	1991-07-22
JPH02233681A (ja)	1990-09-17
OA10041A (en)	1996-10-14
IE62670B1 (en)	1995-03-08
WO1990008148A1 (fr)	1990-07-26
SK279339B6 (sk)	1998-10-07
AR246969A1 (es)	1994-10-31
CN1044464A (zh)	1990-08-08
MX19222A (es)	1993-12-01
PT92919B (pt)	1995-12-29
PT92919A (pt)	1990-07-31
DE69000467D1 (de)	1992-12-24
FI95381B (fi)	1995-10-13
CA2008108C (fr)	1995-08-08
IL93073A (en)	1994-05-30
IS1667B (is)	1997-11-14
AU614214B2 (en)	1991-08-22
CS29990A3 (en)	1992-11-18
ATE82574T1 (de)	1992-12-15
NZ232168A (en)	1991-08-27
EG19306A (en)	1995-01-31
NO912863L (no)	1991-07-22
HUT63163A (en)	1993-07-28
KR900011774A (ko)	1990-08-02
MY104861A (en)	1994-06-30
NO175978B (no)	1994-10-03
DD291560A5 (de)	1991-07-04
AP128A (en)	1991-03-20
EP0380217B1 (fr)	1992-11-19
MA21735A1 (fr)	1990-10-01
FI95381C (fi)	1996-01-25
WO1990008144A1 (fr)	1990-07-26
RO110142B1 (ro)	1995-10-30
JPH0643427B2 (ja)	1994-06-08
DK0380217T3 (da)	1992-12-14
GR3006925T3 (fr)	1993-06-30
YU47554B (sh)	1995-10-03
CA2008108A1 (fr)	1990-07-23
RU2015977C1 (ru)	1994-07-15
YU11190A (sh)	1993-05-28
IS3529A7 (is)	1990-07-24
HU215154B (hu)	2000-09-28

Publication	Publication Date	Title
NO179584C (no)	1996-11-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler
NO175978C (no)	1995-01-11	Analogifremgangsmåte for fremstilling av terapeutisk aktive bis-aza-bicykliske forbindelser
NO180586C (no)	1997-05-14	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte imidazoler
NO179448C (no)	1996-10-09	Analogifremgangsmåte for fremstilling av terapeutisk aktive forbindelser
NO179639C (no)	1996-11-20	Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte piperidinforbindelser
FI96861C (fi)	1996-09-10	Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
FI883739A7 (fi)	1989-02-15	Menetelmä terapeuttisesti aktiivisten fenoksi-indaanimetyyliamiinijohdannaisten valmistamiseksi
NO178619C (no)	1996-05-02	Analogifremgangsmåte for fremstilling av terapeutisk aktive di-t-butylfenoler
NO179283C (no)	1996-09-11	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte azoler
NO176759C (no)	1995-05-24	Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-substituerte-2-oksindol-derivater
FI914905L (fi)	1992-04-19	Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi
FI881223A7 (fi)	1988-09-18	Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi
NO175100C (no)	1994-08-31	Analogifremgangsmåte til fremstilling av terapeutisk aktive 4(3H)-pteridinoner
NO900032D0 (no)	1990-01-04	Fremgangsmaate for fremstilling av terapeutisk aktive tiazol-forbindelser.
NO175528C (no)	1994-10-26	Analogifremgangsmåte for fremstilling av terapeutisk aktive fenylacetamid-derivater
FI923527L (fi)	1992-08-05	Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi
NO173334C (no)	1993-12-01	Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
FI906408L (fi)	1991-06-29	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
NO176273C (no)	1995-03-08	Analogifremgangsmåte for fremstilling av aktive substituerte benzamider
NO173503C (no)	1993-12-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydroimidayo (1,4) benzodiazepin-2-tioner
NO177096C (no)	1995-07-26	Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner
NO174892C (no)	1994-07-27	Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte dihydropyrrolizinforbindelser
FI903077A0 (fi)	1990-06-19	Menetelmä valmistaa terapeuttisesti aktiivisia R(-)-3-kinuklidinolijohdannaisia
NO175781C (no)	1994-12-07	Analogifremgangsmåte for fremstilling av terapeutisk aktive tetracykliske forbindelser
NO174203C (no)	1994-04-06	Analogifremgangsmåte for fremstilling av terapeutisk aktive