NO20002957D0 - Behandling med anti-ErbB2-antistoffer - Google Patents
Behandling med anti-ErbB2-antistofferInfo
- Publication number
- NO20002957D0 NO20002957D0 NO20002957A NO20002957A NO20002957D0 NO 20002957 D0 NO20002957 D0 NO 20002957D0 NO 20002957 A NO20002957 A NO 20002957A NO 20002957 A NO20002957 A NO 20002957A NO 20002957 D0 NO20002957 D0 NO 20002957D0
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- erbb2
- erbb2 antibodies
- invention concerns
- anthracycline
- Prior art date
Links
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 abstract 1
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940045799 anthracyclines and related substance Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229960004679 doxorubicin Drugs 0.000 abstract 1
- 229960001904 epirubicin Drugs 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6934697P | 1997-12-12 | 1997-12-12 | |
| PCT/US1998/026266 WO1999031140A1 (en) | 1997-12-12 | 1998-12-10 | TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20002957D0 true NO20002957D0 (no) | 2000-06-09 |
| NO20002957L NO20002957L (no) | 2000-08-11 |
Family
ID=22088358
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002957A NO20002957L (no) | 1997-12-12 | 2000-06-09 | Behandling med anti-ErbB2-antistoffer |
| NO20091147A NO20091147L (no) | 1997-12-12 | 2009-03-17 | Behandling med anti-ErbB2-antistoff |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20091147A NO20091147L (no) | 1997-12-12 | 2009-03-17 | Behandling med anti-ErbB2-antistoff |
Country Status (17)
| Country | Link |
|---|---|
| US (11) | US7846441B1 (no) |
| EP (3) | EP2277919A1 (no) |
| JP (7) | JP2002508397A (no) |
| KR (7) | KR20130036367A (no) |
| CN (2) | CN1269839C (no) |
| AR (1) | AR020051A1 (no) |
| AU (1) | AU1908199A (no) |
| BR (1) | BR9815363A (no) |
| CA (2) | CA2730373A1 (no) |
| DK (1) | DK1037926T3 (no) |
| ES (1) | ES2450922T3 (no) |
| IL (4) | IL136201A0 (no) |
| NO (2) | NO20002957L (no) |
| NZ (1) | NZ504597A (no) |
| TR (1) | TR200001689T2 (no) |
| WO (1) | WO1999031140A1 (no) |
| ZA (1) | ZA9811162B (no) |
Families Citing this family (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
| US7371376B1 (en) | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| US6972170B1 (en) | 1997-12-01 | 2005-12-06 | Sloan-Kettering Institute For Cancer Research | Markers for prostate cancer |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
| US6333348B1 (en) | 1999-04-09 | 2001-12-25 | Aventis Pharma S.A. | Use of docetaxel for treating cancers |
| US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| WO2000069460A1 (en) * | 1999-05-14 | 2000-11-23 | Genentech, Inc. | TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
| EP1208232A4 (en) * | 1999-06-10 | 2003-01-15 | Sloan Kettering Inst Cancer | PROSTATE CANCER MARKERS |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| KR100754049B1 (ko) * | 1999-06-25 | 2007-08-31 | 제넨테크, 인크. | 전립선암을 치료하기 위한 약제 제조에 사용되는 항-ErbB2 항체 및 조성물 |
| US20040013667A1 (en) * | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| ES2536676T3 (es) * | 1999-06-25 | 2015-05-27 | Genentech, Inc. | Métodos de tratamiento usando conjugados de anticuerpo anti-ErbB-maitansinoide |
| US20030086924A1 (en) * | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US7041292B1 (en) | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
| AU784045B2 (en) * | 1999-06-25 | 2006-01-19 | Genentech Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| AU779612C (en) | 1999-07-02 | 2005-12-15 | Genentech Inc. | Peptide compounds that bind HER2 |
| GB9917012D0 (en) * | 1999-07-20 | 1999-09-22 | Pharmacia & Upjohn Spa | Combined preparations comprising antitumor agents |
| ES2277683T3 (es) | 1999-07-23 | 2007-07-16 | Glaxo Group Limited | Combinacion de anticuerpo anti-ep-cam con un agente quimioterapeutico. |
| AU6620300A (en) | 1999-08-03 | 2001-02-19 | Ohio State University, The | Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein |
| KR20020027587A (ko) | 1999-08-27 | 2002-04-13 | 제넨테크, 인크. | 항-ErbB2 항체 투여 치료 방법 |
| JP4776843B2 (ja) | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
| IL150592A0 (en) | 2000-01-25 | 2003-02-12 | Genentech Inc | Liv-1 related protein, polynucleotides encoding the same and use thereof for treatment of cancer |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| JP2003527441A (ja) * | 2000-03-22 | 2003-09-16 | グラクソ グループ リミテッド | 細胞周期を阻止する薬剤及び抗体を含む医薬 |
| BR0110732A (pt) * | 2000-05-15 | 2003-02-04 | Pharmacia Italia Spa | Inibidores de aromatase e anticorpos anti-her2 monoclonais como agente antitumor |
| CA2407556C (en) * | 2000-05-19 | 2011-06-21 | Genentech, Inc. | Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy |
| GB0017635D0 (en) * | 2000-07-18 | 2000-09-06 | Pharmacia & Upjohn Spa | Antitumor combined therapy |
| WO2002087618A1 (fr) * | 2001-04-27 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Methode de prevention et de traitement du cancer |
| WO2002087619A1 (fr) * | 2001-04-27 | 2002-11-07 | Takeda Chemical Industries, Ltd. | Methode de prevention et de traitement du cancer |
| WO2003089614A2 (en) * | 2002-04-18 | 2003-10-30 | Genencor International, Inc. | Production of functional antibodies in filamentous fungi |
| US20060165647A1 (en) * | 2002-05-30 | 2006-07-27 | Kazuo Teramoto | Immunosuppressive substance adsorbent, extracorporeal cicrulation column and method of treating cancer |
| AU2002951853A0 (en) * | 2002-10-04 | 2002-10-24 | Commonwealth Scientific And Industrial Research Organisation | Crystal structure of erbb2 and uses thereof |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| GT200500155A (es) * | 2004-06-16 | 2006-05-15 | Terapia del càncer resistente al platino | |
| KR20190126461A (ko) | 2004-07-22 | 2019-11-11 | 제넨테크, 인크. | Her2 항체 조성물 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| US20060121044A1 (en) * | 2004-12-07 | 2006-06-08 | Genentech, Inc. | Selecting patients for therapy with a her inhibitor |
| KR20070094928A (ko) | 2005-01-21 | 2007-09-27 | 제넨테크, 인크. | Her 항체의 고정 용량 투여법 |
| BRPI0606557A2 (pt) * | 2005-02-09 | 2009-06-30 | Genentech Inc | método de inibição do abrigo de her2, método de redução do nìvel em soro de domìnio extracelular (ecd) de her2 em mamìferos, métodos de tratamento de cáncer em mamìferos, método de redução do nìvel de p95 her2 em célula e método de diagnóstico |
| MX2007009889A (es) | 2005-02-23 | 2007-09-07 | Genentech Inc | Alargar el tiempo hasta la progresion de la enfermedad o la supervivencia de los pacientes de cancer. |
| TW200642695A (en) * | 2005-03-08 | 2006-12-16 | Genentech Inc | Methods for identifying tumors responsive to treatment with her dimerization inhibitors (HDIs) |
| JP2006316040A (ja) | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(登録商標)補助療法 |
| WO2006138675A2 (en) | 2005-06-15 | 2006-12-28 | The Ohio State University Research Foundation | Her-2 peptides |
| PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| WO2007042809A2 (en) * | 2005-10-11 | 2007-04-19 | Domantis Limited | Antibody polypeptide library screening and selected antibody polypeptides |
| TW200812615A (en) | 2006-03-22 | 2008-03-16 | Hoffmann La Roche | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
| RU2528884C2 (ru) | 2006-08-21 | 2014-09-20 | Ф.Хоффманн-Ля Рош Аг | Лечение опухолей с помощью антитела к vegf |
| WO2008109440A2 (en) | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her dimerisation inhibitor based on low her3 expression |
| US8557588B2 (en) * | 2007-03-27 | 2013-10-15 | Schlumberger Technology Corporation | Methods and apparatus for sampling and diluting concentrated emulsions |
| US20090258005A1 (en) * | 2007-05-29 | 2009-10-15 | Trubion Pharmaceuticals Inc. | Therapeutic compositions and methods |
| US20090304590A1 (en) * | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
| US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
| PL2171090T3 (pl) * | 2007-06-08 | 2013-09-30 | Genentech Inc | Markery ekspresji genów odporności guza na leczenie hamujące HER2 |
| US10416162B2 (en) | 2007-12-20 | 2019-09-17 | Monogram Biosciences, Inc. | Her2 diagnostic methods |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
| ES2342646B1 (es) | 2008-06-02 | 2011-04-26 | Institut De Recerca Hospital Universitari Vall Hebron | Metodo de diagnostico de canceres que expresan el receptor her-2 o sus variantes truncadas. |
| BRPI0812682A2 (pt) * | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| JP2012507299A (ja) * | 2008-10-31 | 2012-03-29 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Light標的分子およびその使用 |
| US20100143351A1 (en) | 2008-11-22 | 2010-06-10 | Genentech, Inc. | Anti-Angiogenesis Therapy for the Treatment of Breast Cancer |
| ES2637411T3 (es) | 2008-12-01 | 2017-10-13 | Laboratory Corporation Of America Holdings | Métodos y ensayos para medir p95 Y/O p95 en una muestra y anticuerpos específicos para p95 |
| SG172983A1 (en) | 2009-01-15 | 2011-08-29 | Lab Corp America Holdings | Methods of determining patient response by measurement of her-3 |
| US20100234283A1 (en) | 2009-02-04 | 2010-09-16 | The Ohio State University Research Foundation | Immunogenic epitopes, peptidomimetics, and anti-peptide antibodies, and methods of their use |
| ES2572728T3 (es) | 2009-03-20 | 2016-06-02 | F. Hoffmann-La Roche Ag | Anticuerpos anti-HER biespecíficos |
| US20120121586A1 (en) | 2009-05-29 | 2012-05-17 | Astrid Kiermaier | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| JP5981853B2 (ja) | 2010-02-18 | 2016-08-31 | ジェネンテック, インコーポレイテッド | ニューレグリンアンタゴニスト及び癌の治療におけるそれらの使用 |
| WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
| CN107253992B (zh) | 2010-05-27 | 2022-03-11 | 根马布股份公司 | 针对her2的单克隆抗体 |
| EP2575880B1 (en) | 2010-05-27 | 2019-01-16 | Genmab A/S | Monoclonal antibodies against her2 epitope |
| EP2582729A4 (en) | 2010-06-18 | 2014-05-28 | Hoffmann La Roche | ANTI-AXL ANTIBODIES AND METHOD FOR THEIR USE |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| CN101974535B (zh) * | 2010-11-03 | 2012-12-19 | 北京天广实生物技术股份有限公司 | 新型抗ErbB2人源化抗体MIL12的制备及其应用 |
| US20130245233A1 (en) | 2010-11-24 | 2013-09-19 | Ming Lei | Multispecific Molecules |
| WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| CA2832389A1 (en) | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
| CN103890007A (zh) | 2011-08-17 | 2014-06-25 | 霍夫曼-拉罗奇有限公司 | 神经调节蛋白抗体及其用途 |
| KR20140057356A (ko) * | 2011-08-31 | 2014-05-12 | 제넨테크, 인크. | 진단 마커 |
| FI4241849T3 (fi) | 2011-10-14 | 2024-11-12 | Hoffmann La Roche | Her2:n dimerisaation estäjä pertutsumabin käyttötapoja ja sitä sisältävä tuote |
| WO2013063229A1 (en) | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
| US20130195870A1 (en) | 2011-11-30 | 2013-08-01 | Genentech, Inc. | ERBB3 Mutations In Cancer |
| EP2788500A1 (en) | 2011-12-09 | 2014-10-15 | F.Hoffmann-La Roche Ag | Identification of non-responders to her2 inhibitors |
| KR20140148388A (ko) | 2012-03-27 | 2014-12-31 | 제넨테크, 인크. | Her3 억제제와 관련된 진단 및 치료 |
| EP2719706A1 (en) | 2012-10-15 | 2014-04-16 | Universität Zürich | Bispecific HER2 ligands for cancer therapy |
| AU2013331763B2 (en) | 2012-10-15 | 2018-02-15 | Universitat Zurich | Bispecific HER2 ligands for cancer therapy |
| WO2014083178A1 (en) | 2012-11-30 | 2014-06-05 | F. Hoffmann-La Roche Ag | Identification of patients in need of pd-l1 inhibitor cotherapy |
| AR095863A1 (es) | 2013-04-16 | 2015-11-18 | Genentech Inc | Variantes de pertuzumab, su evaluación, método de tratamiento, método de preparación y artículo de fabricación |
| RU2015150233A (ru) | 2013-05-01 | 2017-06-02 | Файв Прайм Терапьютикс, Инк. | Способы лечения злокачественной опухоли |
| SG11201608912VA (en) | 2014-04-25 | 2016-11-29 | Genentech Inc | Methods of treating early breast cancer with trastuzumab-mcc-dm1 and pertuzumab |
| CN107614015A (zh) | 2015-05-30 | 2018-01-19 | 豪夫迈·罗氏有限公司 | 治疗her2阳性局部晚期或先前未治疗的转移性乳腺癌的方法 |
| WO2017087280A1 (en) | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
| US20190151346A1 (en) | 2016-05-10 | 2019-05-23 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Combinations therapies for the treatment of cancer |
| JP7011764B2 (ja) * | 2016-07-07 | 2022-01-27 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 抗体アジュバント複合体 |
| US20180134803A1 (en) | 2016-11-04 | 2018-05-17 | Genentech, Inc. | Treatment of her2-positive breast cancer |
| AU2017387909A1 (en) | 2016-12-28 | 2019-06-27 | Genentech, Inc. | Treatment of advanced HER2 expressing cancer |
| TW202508629A (zh) | 2017-01-17 | 2025-03-01 | 美商建南德克公司 | 皮下her2抗體調配物 |
| AU2018227788B2 (en) | 2017-03-02 | 2021-04-22 | F. Hoffmann-La Roche Ag | Adjuvant treatment of HER2-positive breast cancer |
| JP2020517273A (ja) | 2017-04-24 | 2020-06-18 | ジェネンテック, インコーポレイテッド | 膜貫通ドメインまたは膜近傍ドメインにおけるErbB2/Her2突然変異 |
| JP2019043214A (ja) | 2017-08-30 | 2019-03-22 | いすゞ自動車株式会社 | ステアリング装置 |
| CA3113306A1 (en) | 2018-10-08 | 2020-04-16 | Universitat Zurich | Her2-binding tetrameric polypeptides |
| WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| CA3185613A1 (en) | 2020-06-29 | 2022-01-06 | Genentech, Inc. | Pertuzumab plus trastuzumab fixed dose combination |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
Family Cites Families (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US444960A (en) * | 1891-01-20 | Fence or gate | ||
| US4017471A (en) | 1975-09-15 | 1977-04-12 | G. D. Searle & Co. | Immunological compounds |
| US4935341A (en) | 1986-06-04 | 1990-06-19 | Whitehead Institute For Biomedical Research | Detection of point mutations in neu genes |
| US6054561A (en) | 1984-02-08 | 2000-04-25 | Chiron Corporation | Antigen-binding sites of antibody molecules specific for cancer antigens |
| US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
| US5169774A (en) | 1984-02-08 | 1992-12-08 | Cetus Oncology Corporation | Monoclonal anti-human breast cancer antibodies |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| US7838216B1 (en) | 1986-03-05 | 2010-11-23 | The United States Of America, As Represented By The Department Of Health And Human Services | Human gene related to but distinct from EGF receptor gene |
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US4994558A (en) | 1986-12-24 | 1991-02-19 | Eli Lilly And Company | Immunoglobulin conjugates |
| US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
| US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US5720937A (en) | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
| CA1341191C (en) | 1988-04-18 | 2001-02-27 | Robert Allan Weinberg | Detection of neu gene expression and products |
| JP2761543B2 (ja) | 1988-08-17 | 1998-06-04 | 味の素株式会社 | ヒト癌原遺伝子産物に対するモノクローナル抗体及びそれを産生するハイブリドーマ |
| ATE155813T1 (de) | 1989-05-19 | 1997-08-15 | Genentech Inc | Her2 extrazellulare domäne |
| US5705157A (en) | 1989-07-27 | 1998-01-06 | The Trustees Of The University Of Pennsylvania | Methods of treating cancerous cells with anti-receptor antibodies |
| DK0444181T3 (da) | 1989-08-04 | 2002-02-25 | Schering Ag | C-erbB-2 eksternt domæne: gp75 |
| US6884418B1 (en) | 1989-08-04 | 2005-04-26 | Berlex Laboratories, Inc. | Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy |
| JP2895105B2 (ja) | 1989-09-14 | 1999-05-24 | 株式会社ニチレイ | c‐erbB‐2癌遺伝子産物をイムノアッセイする乳癌の血清診断法とそのキット |
| JP3208427B2 (ja) | 1989-09-29 | 2001-09-10 | オー・エス・アイ・ファーマシューテイカルズ・インコーポレイテッド | ヒトの生物学的流体中のneu関連タンパク質の検出及び定量 |
| US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| CA2079585C (en) | 1990-04-06 | 1997-01-07 | Mark I. Greene | Ligand for the neu gene product |
| US5578482A (en) | 1990-05-25 | 1996-11-26 | Georgetown University | Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses |
| CA2074825C (en) | 1990-12-14 | 2005-04-12 | Daniel J. Capon | Chimeric chains for receptor-associated signal transduction pathways |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| US5834229A (en) | 1991-05-24 | 1998-11-10 | Genentech, Inc. | Nucleic acids vectors and host cells encoding and expressing heregulin 2-α |
| US5367060A (en) | 1991-05-24 | 1994-11-22 | Genentech, Inc. | Structure, production and use of heregulin |
| IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| US6407213B1 (en) | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
| US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| US5939531A (en) | 1991-07-15 | 1999-08-17 | Novartis Corp. | Recombinant antibodies specific for a growth factor receptor |
| EP0656367A1 (en) | 1991-08-22 | 1995-06-07 | Becton, Dickinson and Company | Method and composition for cancer therapy and for prognosticating responses to cancer theraphy |
| US5288477A (en) | 1991-09-27 | 1994-02-22 | Becton, Dickinson And Company | Method for prognosticating response to cancer therapy |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| WO1993012220A1 (en) | 1991-12-12 | 1993-06-24 | Berlex Laboratories, Inc. | RECOMBINANT AND CHIMERIC ANTIBODIES TO c-erbB-2 |
| EP0625200B1 (en) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
| US5660827A (en) | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| IT1257898B (it) * | 1992-06-16 | 1996-02-16 | Procedimento ed apparecchiatura per la produzione, in particolare domestica, di bevande. | |
| CA2120745A1 (en) | 1992-06-30 | 1994-01-06 | Philip G. Kasprzyk | A combination of anti-erbb-2 monoclonal antibodies and method of using |
| AU5355594A (en) | 1992-10-09 | 1994-05-09 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by (in situ) hybridization to fixed tissue |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| CA2103323A1 (en) | 1992-11-24 | 1994-05-25 | Gregory D. Plowman | Her4 human receptor tyrosine kinase |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| US5869445A (en) | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
| DE69326937T2 (de) | 1993-03-24 | 2000-12-28 | Berlex Biosciences, Richmond | Kombination von Antihormonale und bindende Moleküle zur Krebsbehandlung |
| AU6527894A (en) | 1993-03-30 | 1994-10-24 | Trustees Of The University Of Pennsylvania, The | Prevention of tumors with monoclonal antibodies against (neu) |
| US5430620A (en) | 1993-10-08 | 1995-07-04 | Cogent Light Technologies, Inc. | Compact surgical illumination system capable of dynamically adjusting the resulting field of illumination |
| US6811779B2 (en) | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
| US20030108545A1 (en) | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
| EP0758196A4 (en) | 1994-05-05 | 1999-05-06 | Univ Pennsylvania | COMPOSITIONS AND METHODS FOR TREATING TUMORS |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| US5846749A (en) | 1994-10-12 | 1998-12-08 | The Regents Of The University Of California | Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination |
| US6214388B1 (en) * | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| DE69504278T2 (de) | 1994-11-10 | 1999-05-06 | Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum, 72076 Tuebingen | Verfahren zur Wachstumshemmung von Leukämischen Zellen durch HER-2-Protein-Zeilen |
| CA2207869A1 (en) | 1994-12-02 | 1996-06-06 | Chiron Corporation | Method of promoting an immune response with a bispecific antibody |
| US5783404A (en) | 1995-04-13 | 1998-07-21 | Amgen Inc. | Methods and compositions for determining HER-2/neu expression using monoclonal antibodies |
| US5663144A (en) | 1995-05-03 | 1997-09-02 | The Trustees Of The University Of Pennsylvania | Compounds that bind to p185 and methods of using the same |
| WO1996037527A1 (en) * | 1995-05-26 | 1996-11-28 | Igen, Inc. | Molecularly imprinted beaded polymers and stabilized suspension polymerization of the same in perfluorocarbon liquids |
| JP3354035B2 (ja) * | 1995-05-31 | 2002-12-09 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料の処理方法 |
| US6410690B1 (en) | 1995-06-07 | 2002-06-25 | Medarex, Inc. | Therapeutic compounds comprised of anti-Fc receptor antibodies |
| AU6113396A (en) | 1995-06-14 | 1997-01-15 | Regents Of The University Of California, The | Novel high affinity human antibodies to tumor antigens |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US5783186A (en) * | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
| EP0894139A1 (en) | 1996-03-20 | 1999-02-03 | Board Of Regents The University Of Texas System | Sensitization of her-2/neu overexpressing cancer cells to chemotherapy |
| US5925519A (en) | 1996-06-03 | 1999-07-20 | The Regents Of The University Of California | Genetic alterations associated with prostate cancer |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| EP0931147A1 (en) | 1996-10-18 | 1999-07-28 | Genentech, Inc. | ANTI-ErbB2 ANTIBODIES |
| WO1998018489A1 (en) | 1996-10-30 | 1998-05-07 | The Uab Research Foundation | Enhancement of tumor cell chemosensitivity and radiosensitivity using single chain intracellular antibodies |
| US20030171551A1 (en) | 1997-01-31 | 2003-09-11 | Joseph D. Rosenblatt | Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response |
| US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
| ZA9811162B (en) * | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| ES2308836T3 (es) | 1998-03-27 | 2008-12-01 | Genentech, Inc. | Sinergia de los anticuerpos anti-her-2 y de los ligands para l'apo-2. |
| ATE321066T1 (de) | 1998-05-06 | 2006-04-15 | Genentech Inc | Anti-her2 antikörperzusammensetzung |
| US6316462B1 (en) | 1999-04-09 | 2001-11-13 | Schering Corporation | Methods of inducing cancer cell death and tumor regression |
| US6333348B1 (en) | 1999-04-09 | 2001-12-25 | Aventis Pharma S.A. | Use of docetaxel for treating cancers |
| WO2000069460A1 (en) | 1999-05-14 | 2000-11-23 | Genentech, Inc. | TREATMENT WITH ANTI-ErbB2 ANTIBODIES |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| US20040013667A1 (en) | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US20030086924A1 (en) | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| KR100754049B1 (ko) | 1999-06-25 | 2007-08-31 | 제넨테크, 인크. | 전립선암을 치료하기 위한 약제 제조에 사용되는 항-ErbB2 항체 및 조성물 |
| US7041292B1 (en) | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
| KR20020027587A (ko) | 1999-08-27 | 2002-04-13 | 제넨테크, 인크. | 항-ErbB2 항체 투여 치료 방법 |
| US7097840B2 (en) * | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| BR0110732A (pt) | 2000-05-15 | 2003-02-04 | Pharmacia Italia Spa | Inibidores de aromatase e anticorpos anti-her2 monoclonais como agente antitumor |
| CA2407556C (en) | 2000-05-19 | 2011-06-21 | Genentech, Inc. | Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy |
| AU2002239486A1 (en) | 2000-12-08 | 2002-06-18 | Uab Research Foundation | Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody |
| AU2002219221B2 (en) | 2001-01-09 | 2007-05-17 | Merck Patent Gmbh | Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors |
| PL214010B1 (pl) | 2002-07-15 | 2013-06-28 | Genentech Inc | Rekombinowane humanizowane przeciwcialo 2C4 i zastosowanie tego przeciwciala |
| WO2004048525A2 (en) | 2002-11-21 | 2004-06-10 | Genentech, Inc. | Therapy of non-malignant diseases or disorders with anti-erbb2 antibodies |
| WO2005099756A2 (en) | 2004-04-08 | 2005-10-27 | Agus David B | ErbB ANTAGONISTS FOR PAIN THERAPY |
| GT200500155A (es) | 2004-06-16 | 2006-05-15 | Terapia del càncer resistente al platino | |
| KR20190126461A (ko) | 2004-07-22 | 2019-11-11 | 제넨테크, 인크. | Her2 항체 조성물 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| US20060121044A1 (en) | 2004-12-07 | 2006-06-08 | Genentech, Inc. | Selecting patients for therapy with a her inhibitor |
| KR20070094928A (ko) | 2005-01-21 | 2007-09-27 | 제넨테크, 인크. | Her 항체의 고정 용량 투여법 |
| MX2007009889A (es) | 2005-02-23 | 2007-09-07 | Genentech Inc | Alargar el tiempo hasta la progresion de la enfermedad o la supervivencia de los pacientes de cancer. |
| TW200642695A (en) | 2005-03-08 | 2006-12-16 | Genentech Inc | Methods for identifying tumors responsive to treatment with her dimerization inhibitors (HDIs) |
| JP2006316040A (ja) * | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(登録商標)補助療法 |
| PE20070207A1 (es) | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| US7700299B2 (en) | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
| TW200812615A (en) | 2006-03-22 | 2008-03-16 | Hoffmann La Roche | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
| KR20090019890A (ko) | 2006-06-05 | 2009-02-25 | 제넨테크, 인크. | Egf 또는 tgf-알파 수준이 상승된 암 환자의 생존 연장 |
| JP5317084B2 (ja) | 2006-11-08 | 2013-10-16 | 国立大学法人愛媛大学 | π共役環状化合物およびその製造方法 |
| WO2008109440A2 (en) * | 2007-03-02 | 2008-09-12 | Genentech, Inc. | Predicting response to a her dimerisation inhibitor based on low her3 expression |
| JP5117165B2 (ja) | 2007-11-09 | 2013-01-09 | 花王株式会社 | 水中油型乳化組成物の製造方法 |
| JP5170667B2 (ja) | 2008-06-02 | 2013-03-27 | 小林クリエイト株式会社 | 情報隠蔽帳票 |
| BRPI0812682A2 (pt) * | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| JP5213775B2 (ja) | 2009-03-25 | 2013-06-19 | 株式会社ジャパンディスプレイウェスト | 電気光学装置および電子機器 |
-
1998
- 1998-12-07 ZA ZA9811162A patent/ZA9811162B/xx unknown
- 1998-12-10 EP EP10178009A patent/EP2277919A1/en not_active Ceased
- 1998-12-10 EP EP10177992A patent/EP2275450A1/en not_active Withdrawn
- 1998-12-10 KR KR1020137005286A patent/KR20130036367A/ko not_active Ceased
- 1998-12-10 AU AU19081/99A patent/AU1908199A/en not_active Abandoned
- 1998-12-10 KR KR1020107028433A patent/KR20100135337A/ko not_active Ceased
- 1998-12-10 CA CA2730373A patent/CA2730373A1/en not_active Abandoned
- 1998-12-10 ES ES98963840.8T patent/ES2450922T3/es not_active Expired - Lifetime
- 1998-12-10 CA CA2311409A patent/CA2311409C/en not_active Expired - Lifetime
- 1998-12-10 TR TR2000/01689T patent/TR200001689T2/xx unknown
- 1998-12-10 EP EP98963840.8A patent/EP1037926B1/en not_active Revoked
- 1998-12-10 IL IL13620198A patent/IL136201A0/xx unknown
- 1998-12-10 JP JP2000539062A patent/JP2002508397A/ja not_active Withdrawn
- 1998-12-10 KR KR1020087018921A patent/KR20080075042A/ko not_active Ceased
- 1998-12-10 KR KR1020147035850A patent/KR20150013870A/ko not_active Ceased
- 1998-12-10 KR KR1020127013045A patent/KR20120062942A/ko not_active Withdrawn
- 1998-12-10 KR KR1020187027274A patent/KR20180107323A/ko not_active Ceased
- 1998-12-10 BR BR9815363-3A patent/BR9815363A/pt not_active Application Discontinuation
- 1998-12-10 WO PCT/US1998/026266 patent/WO1999031140A1/en active Application Filing
- 1998-12-10 KR KR1020007006372A patent/KR20010033019A/ko not_active Ceased
- 1998-12-10 CN CNB988120976A patent/CN1269839C/zh not_active Expired - Lifetime
- 1998-12-10 CN CN200610008639XA patent/CN1820734B/zh not_active Ceased
- 1998-12-10 DK DK98963840.8T patent/DK1037926T3/da active
- 1998-12-10 US US09/208,649 patent/US7846441B1/en not_active Expired - Fee Related
- 1998-12-11 AR ARP980106308A patent/AR020051A1/es unknown
-
2000
- 2000-05-17 NZ NZ504597A patent/NZ504597A/en not_active IP Right Cessation
- 2000-05-17 IL IL136201A patent/IL136201A/en not_active IP Right Cessation
- 2000-06-09 NO NO20002957A patent/NO20002957L/no unknown
-
2003
- 2003-02-03 US US10/356,824 patent/US7892549B2/en not_active Expired - Fee Related
- 2003-04-04 US US10/406,925 patent/US20030170234A1/en not_active Abandoned
-
2004
- 2004-08-02 US US10/909,998 patent/US8642036B2/en not_active Expired - Lifetime
-
2007
- 2007-07-20 US US11/780,640 patent/US8075892B2/en not_active Expired - Fee Related
-
2008
- 2008-01-04 US US11/969,465 patent/US20080187533A1/en not_active Abandoned
-
2009
- 2009-03-17 NO NO20091147A patent/NO20091147L/no not_active Application Discontinuation
-
2010
- 2010-04-07 JP JP2010088515A patent/JP2010209081A/ja active Pending
-
2011
- 2011-05-09 US US13/103,799 patent/US8309087B2/en not_active Expired - Fee Related
- 2011-07-14 IL IL214084A patent/IL214084A/en not_active IP Right Cessation
- 2011-07-18 US US13/185,329 patent/US8425908B2/en not_active Expired - Fee Related
-
2012
- 2012-10-04 JP JP2012222108A patent/JP2013056887A/ja not_active Withdrawn
-
2013
- 2013-03-15 US US13/841,146 patent/US20130209459A1/en not_active Abandoned
- 2013-12-26 US US14/141,232 patent/US20140341886A1/en not_active Abandoned
-
2014
- 2014-09-17 IL IL234696A patent/IL234696A/en not_active IP Right Cessation
-
2015
- 2015-06-09 JP JP2015116874A patent/JP2016006046A/ja not_active Withdrawn
-
2016
- 2016-09-23 JP JP2016185281A patent/JP2017039737A/ja active Pending
-
2017
- 2017-04-05 JP JP2017075241A patent/JP2017165737A/ja not_active Withdrawn
-
2018
- 2018-12-05 JP JP2018227941A patent/JP2019055979A/ja active Pending
-
2019
- 2019-04-23 US US16/392,300 patent/US20190240185A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20002957D0 (no) | Behandling med anti-ErbB2-antistoffer | |
| IL254264A (en) | Doses for treatments using anti-erbb2 antibodies | |
| PT1187632E (pt) | Tratamento com anticorpos anti-erbb2 | |
| ATE324119T1 (de) | Verwendung von saccharid-konjugaten | |
| EP0536275A4 (en) | Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof | |
| AU3053395A (en) | Immunoconjugates II | |
| FR12C0004I1 (no) | ||
| EP0669482A3 (de) | Reibbelag. | |
| WO1999066951A3 (en) | Use of bi-specific antibodies for pre-targeting diagnosis and therapy | |
| NO883306D0 (no) | Farmasoeytisk aktive konjugater med forbedret bindingsspesifisitet for kroppsvev. | |
| ES2159318T3 (es) | Inhibidores de la proteina quinasa c. | |
| EA200000978A1 (ru) | Противоопухолевая композиция, содержащая синергическую комбинацию производного антрациклина и производного камптотецина | |
| BR9915460A (pt) | Método de tratamento de febre hemorrágica virótica | |
| EP1947119A3 (en) | Treatment of cancer with anti-erb2 antibodies in combination with a chemotherapeutic agent | |
| DK0561183T3 (da) | Monoklonalt anti-gangliosid-antistof, fremstilling deraf og anvendelse deraf som tumorterapeutikum | |
| FI851170A7 (fi) | Spiro-indeenit ja spiro-1,2 -dihydronaftaleenit sokeritaudin komplikaatioiden hoitoon. | |
| DE3888924D1 (de) | Monoklonale Antikörper gegen Anthracycline. | |
| IT234696Y1 (it) | Orologio da polso ad agevole consultazione duranta la guida o simili. | |
| IT8941548A0 (it) | Struttura di fermaglio particolarmente per cinturini di orologi, bracciali, spille o simili. |