NO20030393L - Effektiv ligand-mediert Ullmann-kobling av aniliner og azoler - Google Patents
Effektiv ligand-mediert Ullmann-kobling av aniliner og azolerInfo
- Publication number
- NO20030393L NO20030393L NO20030393A NO20030393A NO20030393L NO 20030393 L NO20030393 L NO 20030393L NO 20030393 A NO20030393 A NO 20030393A NO 20030393 A NO20030393 A NO 20030393A NO 20030393 L NO20030393 L NO 20030393L
- Authority
- NO
- Norway
- Prior art keywords
- azoles
- anilines
- ullmann coupling
- efficient ligand
- mediated ullmann
- Prior art date
Links
- 238000006887 Ullmann reaction Methods 0.000 title abstract 2
- 150000001448 anilines Chemical class 0.000 title abstract 2
- 150000003851 azoles Chemical class 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 229940123583 Factor Xa inhibitor Drugs 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- -1 phenyl-substituted azoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Executing Machine-Instructions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22093200P | 2000-07-26 | 2000-07-26 | |
| PCT/US2001/023541 WO2002008199A2 (fr) | 2000-07-26 | 2001-07-26 | Couplage ullmann entre anilines et azoles par médiation ligandaire |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20030393D0 NO20030393D0 (no) | 2003-01-24 |
| NO20030393L true NO20030393L (no) | 2003-03-24 |
Family
ID=22825611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030393A NO20030393L (no) | 2000-07-26 | 2003-01-24 | Effektiv ligand-mediert Ullmann-kobling av aniliner og azoler |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6541639B2 (fr) |
| EP (1) | EP1307431B1 (fr) |
| JP (1) | JP2004504384A (fr) |
| KR (1) | KR20030060872A (fr) |
| CN (1) | CN1444565A (fr) |
| AT (1) | ATE307804T1 (fr) |
| AU (1) | AU2001280813A1 (fr) |
| BR (1) | BR0112746A (fr) |
| CA (1) | CA2417426A1 (fr) |
| DE (1) | DE60114424T2 (fr) |
| EC (1) | ECSP034453A (fr) |
| ES (1) | ES2251501T3 (fr) |
| HU (1) | HUP0301699A3 (fr) |
| IL (1) | IL153547A0 (fr) |
| IS (1) | IS6695A (fr) |
| MX (1) | MXPA03000686A (fr) |
| NO (1) | NO20030393L (fr) |
| NZ (1) | NZ523271A (fr) |
| PL (1) | PL361233A1 (fr) |
| RU (1) | RU2003103706A (fr) |
| WO (1) | WO2002008199A2 (fr) |
| ZA (1) | ZA200300039B (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1266112C (zh) * | 2001-04-24 | 2006-07-26 | 麻省理工学院 | 铜－催化的碳－杂原子键和碳－碳键的形成 |
| CA2476594C (fr) | 2002-03-05 | 2012-10-09 | Transtech Pharma, Inc. | Derives de l'azole et derives bicycliques fusionnes de l'azole, agents therapeutiques |
| CN1668595A (zh) * | 2002-05-31 | 2005-09-14 | 罗狄亚化学公司 | 形成碳－碳或碳－杂原子键的方法 |
| CA2494404A1 (fr) | 2002-08-02 | 2004-02-12 | Massachusetts Institute Of Technology | Formation de liaisons carbone-heteroatome et carbone-carbone catalysee par du cuivre |
| US20040067995A1 (en) * | 2002-10-02 | 2004-04-08 | Wong Pancras C. | Novel combination of a factor Xa inhibitor and clopidogrel |
| JP2007503469A (ja) * | 2003-05-20 | 2007-02-22 | トランス テック ファーマ，インコーポレイテッド | アミロイド症およびそれに関連した疾患を改善するための作用物質としてのｒａｇｅアンタゴニスト |
| CN1984872A (zh) * | 2004-07-16 | 2007-06-20 | 帝斯曼知识产权资产管理有限公司 | 制备（杂）芳胺的方法 |
| KR102065319B1 (ko) | 2007-03-12 | 2020-01-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
| WO2011041198A1 (fr) | 2009-09-30 | 2011-04-07 | Transtech Pharma, Inc. | Dérivés d'imidazole substitués pour traiter la maladie d'alzheimer |
| US11053245B2 (en) | 2012-04-14 | 2021-07-06 | Intra-Cellular Therapies, Inc. | Methods |
| ES2846823T3 (es) | 2013-03-15 | 2021-07-29 | Intra Cellular Therapies Inc | Compuestos orgánicos |
| CA3205777A1 (en) | 2013-12-03 | 2015-06-11 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carboline compounds for use in treatment of schizophrenia |
| CN106535898A (zh) | 2014-04-04 | 2017-03-22 | 细胞内治疗公司 | 有机化合物 |
| CN106456638A (zh) | 2014-04-04 | 2017-02-22 | 细胞内治疗公司 | 有机化合物 |
| WO2015171951A1 (fr) * | 2014-05-07 | 2015-11-12 | The Regents Of The University Of Colorado, A Body Corporate | Composés 2-(4-aryl-1h-imidazol-1-yl)aniline |
| EP3838274B1 (fr) | 2016-01-26 | 2023-11-01 | Intra-Cellular Therapies, Inc. | Dérivé de pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline pour son utilisation dans les traitements de troubles du snc |
| IL314312A (en) | 2016-03-25 | 2024-09-01 | Intra Cellular Therapies Inc | A sustained-release or delayed-release pharmaceutical composition comprising a deuterated compound |
| US10654854B2 (en) | 2016-03-28 | 2020-05-19 | Intra-Cellular Therapies, Inc. | Salts and crystals of ITI-007 |
| EP3436083A4 (fr) | 2016-03-28 | 2019-11-27 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et méthodes |
| EP3436016B1 (fr) | 2016-03-28 | 2022-04-27 | Intra-Cellular Therapies, Inc. | Nouveaux co-cristaux |
| JP7013454B2 (ja) | 2016-10-12 | 2022-02-15 | イントラ－セルラー・セラピーズ・インコーポレイテッド | アモルファス固体分散体 |
| WO2018126140A1 (fr) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Composés organiques |
| WO2018126143A1 (fr) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Composés organiques |
| MX395214B (es) | 2017-03-24 | 2025-03-25 | Intra Cellular Therapies Inc | Composiciones novedosas y metodos |
| AU2018307480B2 (en) | 2017-07-26 | 2023-11-23 | Intra-Cellular Therapies, Inc. | Organic compounds |
| BR112020001666A2 (pt) | 2017-07-26 | 2020-07-21 | Intra-Cellular Therapies, Inc. | compostos orgânicos |
| SG11202008560VA (en) | 2018-03-08 | 2020-10-29 | Incyte Corp | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS |
| CA3094949A1 (fr) | 2018-03-23 | 2019-09-26 | Intra-Cellular Therapies, Inc. | Gamma-carbolines fusionnees a heterocycles deuteres |
| CN112384218B (zh) | 2018-06-06 | 2024-04-26 | 细胞内治疗公司 | 盐和晶体 |
| ES3028377T3 (en) | 2018-06-08 | 2025-06-19 | Intra Cellular Therapies Inc | Fused gamma-carbolines for acute treatment of anxiety or depression |
| EP3609891A4 (fr) | 2018-06-11 | 2021-04-14 | Intra-Cellular Therapies, Inc. | Synthèse de gamma-carbolines fusionnées à hétérocycles substitués |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| EP3843729A4 (fr) | 2018-08-29 | 2022-06-01 | Intra-Cellular Therapies, Inc. | Nouvelles compositions et méthodes |
| WO2020047407A1 (fr) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Nouvelles méthodes |
| CN118873536A (zh) | 2018-08-31 | 2024-11-01 | 细胞内治疗公司 | 新方法 |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| EP3898580A4 (fr) | 2018-12-17 | 2022-08-10 | Intra-Cellular Therapies, Inc. | Synthèse de gamma-carbolines fusionnées à hétérocycles substitués |
| EP3898581B1 (fr) | 2018-12-17 | 2025-08-27 | Intra-Cellular Therapies, Inc. | Synthèse de gamma-carbolines fusionnées à hétérocycles substitués |
| WO2021007245A1 (fr) | 2019-07-07 | 2021-01-14 | Intra-Cellular Therapies, Inc. | Nouveaux procédés |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6372658A (ja) | 1986-09-17 | 1988-04-02 | Sumitomo Chem Co Ltd | ニトロジフエニルアミン類の製造方法 |
| US5705697A (en) | 1997-01-30 | 1998-01-06 | Xerox Corporation | Arylamine processes |
| ZA985247B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
-
2001
- 2001-07-25 US US09/912,950 patent/US6541639B2/en not_active Expired - Fee Related
- 2001-07-26 CN CN01813378A patent/CN1444565A/zh active Pending
- 2001-07-26 PL PL36123301A patent/PL361233A1/xx not_active Application Discontinuation
- 2001-07-26 EP EP01959231A patent/EP1307431B1/fr not_active Expired - Lifetime
- 2001-07-26 NZ NZ523271A patent/NZ523271A/en unknown
- 2001-07-26 KR KR10-2003-7001155A patent/KR20030060872A/ko not_active Withdrawn
- 2001-07-26 ES ES01959231T patent/ES2251501T3/es not_active Expired - Lifetime
- 2001-07-26 AU AU2001280813A patent/AU2001280813A1/en not_active Abandoned
- 2001-07-26 DE DE60114424T patent/DE60114424T2/de not_active Expired - Fee Related
- 2001-07-26 RU RU2003103706/04A patent/RU2003103706A/ru not_active Application Discontinuation
- 2001-07-26 CA CA002417426A patent/CA2417426A1/fr not_active Abandoned
- 2001-07-26 JP JP2002514105A patent/JP2004504384A/ja active Pending
- 2001-07-26 BR BR0112746-2A patent/BR0112746A/pt not_active IP Right Cessation
- 2001-07-26 MX MXPA03000686A patent/MXPA03000686A/es unknown
- 2001-07-26 IL IL15354701A patent/IL153547A0/xx unknown
- 2001-07-26 AT AT01959231T patent/ATE307804T1/de not_active IP Right Cessation
- 2001-07-26 WO PCT/US2001/023541 patent/WO2002008199A2/fr active IP Right Grant
- 2001-07-26 HU HU0301699A patent/HUP0301699A3/hu unknown
-
2003
- 2003-01-02 ZA ZA200300039A patent/ZA200300039B/en unknown
- 2003-01-22 IS IS6695A patent/IS6695A/is unknown
- 2003-01-24 NO NO20030393A patent/NO20030393L/no not_active Application Discontinuation
- 2003-01-24 EC EC2003004453A patent/ECSP034453A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1307431B1 (fr) | 2005-10-26 |
| WO2002008199A3 (fr) | 2002-06-13 |
| IL153547A0 (en) | 2003-07-06 |
| PL361233A1 (en) | 2004-10-04 |
| JP2004504384A (ja) | 2004-02-12 |
| BR0112746A (pt) | 2003-09-09 |
| MXPA03000686A (es) | 2003-06-06 |
| HUP0301699A2 (hu) | 2003-12-29 |
| RU2003103706A (ru) | 2004-08-10 |
| ATE307804T1 (de) | 2005-11-15 |
| NO20030393D0 (no) | 2003-01-24 |
| ZA200300039B (en) | 2004-04-02 |
| DE60114424T2 (de) | 2006-07-27 |
| EP1307431A2 (fr) | 2003-05-07 |
| CN1444565A (zh) | 2003-09-24 |
| KR20030060872A (ko) | 2003-07-16 |
| HUP0301699A3 (en) | 2004-03-29 |
| US6541639B2 (en) | 2003-04-01 |
| CA2417426A1 (fr) | 2002-01-31 |
| US20020099225A1 (en) | 2002-07-25 |
| ECSP034453A (es) | 2003-03-31 |
| NZ523271A (en) | 2005-01-28 |
| AU2001280813A1 (en) | 2002-02-05 |
| WO2002008199A2 (fr) | 2002-01-31 |
| IS6695A (is) | 2003-01-22 |
| DE60114424D1 (de) | 2005-12-01 |
| ES2251501T3 (es) | 2006-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |