NO308074B1 - FremgangsmÕte for racemisering av optiske anrikete heterocykliske karboksanilider - Google Patents
FremgangsmÕte for racemisering av optiske anrikete heterocykliske karboksaniliderInfo
- Publication number
- NO308074B1 NO308074B1 NO971358A NO971358A NO308074B1 NO 308074 B1 NO308074 B1 NO 308074B1 NO 971358 A NO971358 A NO 971358A NO 971358 A NO971358 A NO 971358A NO 308074 B1 NO308074 B1 NO 308074B1
- Authority
- NO
- Norway
- Prior art keywords
- pct
- compound
- carboxanilides
- racemization
- date
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 230000006340 racemization Effects 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- -1 piperidine-2-carboxanilide compound Chemical class 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Measurement Of Radiation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94306962 | 1994-09-23 | ||
| GBGB9504927.6A GB9504927D0 (en) | 1995-03-10 | 1995-03-10 | Racemisation and asymmetric transformation |
| PCT/GB1995/002247 WO1996009290A1 (en) | 1994-09-23 | 1995-09-22 | Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO971358L NO971358L (no) | 1997-03-21 |
| NO971358D0 NO971358D0 (no) | 1997-03-21 |
| NO308074B1 true NO308074B1 (no) | 2000-07-17 |
Family
ID=26137306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO971358A NO308074B1 (no) | 1994-09-23 | 1997-03-21 | FremgangsmÕte for racemisering av optiske anrikete heterocykliske karboksanilider |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5786484A (no) |
| EP (1) | EP0782569B1 (no) |
| JP (1) | JP3898220B2 (no) |
| KR (1) | KR100393133B1 (no) |
| CN (1) | CN1104416C (no) |
| AT (1) | ATE214695T1 (no) |
| AU (1) | AU695479B2 (no) |
| CA (1) | CA2200490C (no) |
| DE (1) | DE69525950T2 (no) |
| DK (1) | DK0782569T3 (no) |
| ES (1) | ES2173194T3 (no) |
| FI (1) | FI117436B (no) |
| HU (1) | HU216291B (no) |
| MX (1) | MX9702210A (no) |
| NO (1) | NO308074B1 (no) |
| PL (1) | PL183204B1 (no) |
| PT (1) | PT782569E (no) |
| WO (1) | WO1996009290A1 (no) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
| JP2000256359A (ja) * | 1999-03-11 | 2000-09-19 | Japan Science & Technology Corp | 面性キラリティーを有する分子群の高選択的不斉変換法 |
| US6288280B1 (en) * | 1999-07-09 | 2001-09-11 | Hoffmann-La Roche Inc. | Racemization of atropisomeric bis(phosphine oxide) compounds |
| BR0002246A (pt) * | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
| US6962998B2 (en) | 2000-06-14 | 2005-11-08 | Toray Industries, Inc. | Processes for producing racemic piperidine derivative and for producing optically active piperidine derivative |
| US6495694B2 (en) | 2000-06-16 | 2002-12-17 | Boehringer Ingelheim Pharma Kg | Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer |
| DE10029851A1 (de) * | 2000-06-16 | 2001-12-20 | Boehringer Ingelheim Pharma | Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers |
| BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| AU2003299659A1 (en) | 2002-12-13 | 2004-07-09 | Durect Corporation | Oral drug delivery system comprising high viscosity liquid carrier materials |
| ES2496765T3 (es) | 2004-09-17 | 2014-09-19 | Durect Corporation | Composición anestésica local prolongada que contiene SAIB |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| CA2677750A1 (en) | 2006-11-03 | 2008-06-05 | Durect Corporation | Transdermal delivery systems |
| CA2706931C (en) | 2007-12-06 | 2015-05-12 | Durect Corporation | Oral pharmaceutical dosage forms |
| US20100260844A1 (en) * | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
| CN105120659A (zh) | 2013-03-15 | 2015-12-02 | 度瑞公司 | 用于降低溶解可变性的具有流变改性剂的组合物 |
| CN103664744B (zh) * | 2013-11-30 | 2015-07-15 | 山东永泰化工有限公司 | 一种左布比卡因的制备方法 |
| SG11201811760VA (en) | 2016-07-06 | 2019-01-30 | Durect Corp | Oral dosage form with drug composition, barrier layer and drug layer |
| AU2019270163A1 (en) * | 2018-05-18 | 2020-12-03 | Kura Oncology, Inc. | Synthesis of tipifarnib |
| BR112022013784A2 (pt) | 2020-01-13 | 2022-10-11 | Durect Corp | Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados |
| EP4277702A1 (en) | 2021-01-12 | 2023-11-22 | Durect Corporation | Sustained release drug delivery systems and related methods |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
-
1995
- 1995-09-22 HU HU9702212A patent/HU216291B/hu unknown
- 1995-09-22 KR KR1019970701774A patent/KR100393133B1/ko not_active Expired - Lifetime
- 1995-09-22 JP JP51069496A patent/JP3898220B2/ja not_active Expired - Lifetime
- 1995-09-22 MX MX9702210A patent/MX9702210A/es unknown
- 1995-09-22 DE DE69525950T patent/DE69525950T2/de not_active Expired - Lifetime
- 1995-09-22 CA CA002200490A patent/CA2200490C/en not_active Expired - Lifetime
- 1995-09-22 PT PT95932092T patent/PT782569E/pt unknown
- 1995-09-22 US US08/809,941 patent/US5786484A/en not_active Expired - Lifetime
- 1995-09-22 AU AU35279/95A patent/AU695479B2/en not_active Expired
- 1995-09-22 EP EP95932092A patent/EP0782569B1/en not_active Expired - Lifetime
- 1995-09-22 WO PCT/GB1995/002247 patent/WO1996009290A1/en active IP Right Grant
- 1995-09-22 CN CN95195252A patent/CN1104416C/zh not_active Expired - Lifetime
- 1995-09-22 PL PL95319368A patent/PL183204B1/pl unknown
- 1995-09-22 DK DK95932092T patent/DK0782569T3/da active
- 1995-09-22 AT AT95932092T patent/ATE214695T1/de active
- 1995-09-22 ES ES95932092T patent/ES2173194T3/es not_active Expired - Lifetime
-
1997
- 1997-03-21 FI FI971202A patent/FI117436B/fi not_active IP Right Cessation
- 1997-03-21 NO NO971358A patent/NO308074B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5786484A (en) | 1998-07-28 |
| AU695479B2 (en) | 1998-08-13 |
| FI971202A0 (fi) | 1997-03-21 |
| EP0782569A1 (en) | 1997-07-09 |
| DK0782569T3 (da) | 2002-07-22 |
| ATE214695T1 (de) | 2002-04-15 |
| AU3527995A (en) | 1996-04-09 |
| PL183204B1 (pl) | 2002-06-28 |
| CA2200490A1 (en) | 1996-03-28 |
| CN1104416C (zh) | 2003-04-02 |
| DE69525950D1 (de) | 2002-04-25 |
| CN1159184A (zh) | 1997-09-10 |
| JP3898220B2 (ja) | 2007-03-28 |
| NO971358L (no) | 1997-03-21 |
| CA2200490C (en) | 2007-01-09 |
| NO971358D0 (no) | 1997-03-21 |
| PT782569E (pt) | 2002-09-30 |
| PL319368A1 (en) | 1997-08-04 |
| EP0782569B1 (en) | 2002-03-20 |
| JPH10505855A (ja) | 1998-06-09 |
| DE69525950T2 (de) | 2002-09-19 |
| KR100393133B1 (ko) | 2003-11-17 |
| FI971202L (fi) | 1997-03-21 |
| HUT77055A (hu) | 1998-03-02 |
| ES2173194T3 (es) | 2002-10-16 |
| MX9702210A (es) | 1998-05-31 |
| WO1996009290A1 (en) | 1996-03-28 |
| FI117436B (fi) | 2006-10-13 |
| HU216291B (hu) | 1999-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |