NO930790L

NO930790L - thiazolidine derivatives

Info

Publication number: NO930790L
Application number: NO93930790A
Authority: NO
Inventors: Jan Bron; Geert Jan Sterk; Jan Fetze Van Der Werf; Hendrik Timmerman
Original assignee: Cedona Pharm Bv
Priority date: 1990-09-05
Filing date: 1993-03-04
Publication date: 1993-03-04
Also published as: NO930790D0

Abstract

Forbindelser med den generelle formel (I) hvor R1 er H eller C1_4-alkyl, R2 er H, C^ C4_8-cykloalkyl, fenyl-C1_3-alkyl eller en gruppe av generell formel 2 hvor R9 og R]^ samtidig eller separat er H, C^ C^.g-alkoksyl, C4_8-cykloalkyl, F, Cl, Br, NO2, nitroksy-C2_g-alkoksyl, nitroksy-4-8C-cykloalkoksyl, nitroksy-C1_2-alkyl-C4_8-cykloalkyl-C1-2-alkoksyl eller en gruppe -W-CO-Y-R]_2» hvor W er en binding eller en - OCH2-gruppe, Y er O eller en iminogruppe og R12 er H, C]__4-alkyl, C4_g-cykloalkyl, nitroksy-C2_g-alkyl eller nitroksy-C4_s-cykoalkyl, R3 og R4 er H eller C1-4- alkyl, R5 er H eller en -CO-Z-R7-gruppe hvor Z er O eller en imino-gruppe og R7 er H, C1_4-alkyl, C4_8- cykloalkyl, nitroksy-C2_6-alkyl, nitroksy-C4_8-cyklo- alkyl, nitroksy-Ci_2-alkyl-C4_3-cykloalkyl-Ci_2-alkyl eller 4-nitroksy-2,6-dioksabicyklo[3.3.0]okt-8-yl og R6 er H eller en gruppe -X-R8 hvor X er karbonyl eller sulfonyl og R8 er C1_4-alkyl, C4_a-cykloalkyl, nitroksy- C2_6-alkyl, nitroksy-C4_8-cykloalkyl, fenyl eller C^_4-alkylfenyl samt salter derav er nye forbindelser med markert kardiovaskulær aktivitet.Compounds of general formula (I) wherein R 1 is H or C 1-4 alkyl, R 2 is H, C 1-4 cycloalkyl, phenyl-C 1-3 alkyl or a group of general formula 2 wherein R 9 and R 11 are simultaneously or separately H , C ^ C ^g alkoxyl, C4_4 cycloalkyl, F, Cl, Br, NO₂, nitroxy-C₂_2 alkoxyl, nitroxy-4-8C-cycloalkoxyl, nitroxy-C1₂-alkyl-C4_-cycloalkyl-C alkoxyl or a group -W-CO-YR] -2 where W is a bond or a - OCH2 group, Y is O or an imino group and R12 is H, C1-4 alkyl, C4-6 cycloalkyl, nitroxy-C2 alkyl or nitroxy-C4-8 cycoalkyl, R3 and R4 are H or C1-4 alkyl, R5 is H or a -CO-Z-R7 group where Z is O or an imino group and R7 is H, C1-4 alkyl , C4-8 cycloalkyl, nitroxy-C2-6-alkyl, nitroxy-C4-8-cycloalkyl, nitroxy-C1-2-alkyl-C4-3-cycloalkyl-C1-2-alkyl or 4-nitroxy-2,6-dioxabicyclo [3.3.0] Oct-8 -yl and R6 are H or a group -X-R8 where X is carbonyl or sulfonyl and R8 is C1-4 alkyl, C4a-cycloalkyl, nitroxy-C2-6 alkyl, nitroxy-C4-8 cycloalkyl or C 1-4 alkylphenyl as well as salts thereof are novel compounds of marked cardiovascular activity.