NO993768L - Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet - Google Patents

Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet

Info

Publication number: NO993768L
Authority: NO; Norway
Prior art keywords: compounds; ampa receptor; improve; receptor activity; receptors
Prior art date: 1997-02-13

Application number

NO993768A

Other languages

English (en)

Other versions

NO318935B1 (no

NO993768D0 (no

Inventor

Gary A Rogers

Christopher M Marrs

Original Assignee

Univ California

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-13

Filing date

1999-08-04

Publication date

1999-09-23

1999-08-04 Application filed by Univ California filed Critical Univ California

1999-08-04 Publication of NO993768D0 publication Critical patent/NO993768D0/no

1999-09-23 Publication of NO993768L publication Critical patent/NO993768L/no

2005-05-30 Publication of NO318935B1 publication Critical patent/NO318935B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Luminescent Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Furan Compounds (AREA)

NO19993768A 1997-02-13 1999-08-04 Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet NO318935B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/800,108 US6110935A (en)	1997-02-13	1997-02-13	Benzofurazan compounds for enhancing glutamatergic synaptic responses
PCT/US1998/002713 WO1998035950A1 (en)	1997-02-13	1998-02-13	Benzofurazan compounds which enhance ampa receptor activity

Publications (3)

Publication Number	Publication Date
NO993768D0 NO993768D0 (no)	1999-08-04
NO993768L true NO993768L (no)	1999-09-23
NO318935B1 NO318935B1 (no)	2005-05-30

Family

ID=25177504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19993768A NO318935B1 (no)	1997-02-13	1999-08-04	Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet

Country Status (24)

Country	Link
US (3)	US6110935A (no)
EP (2)	EP1428534B1 (no)
JP (1)	JP4446023B2 (no)
KR (1)	KR100544295B1 (no)
CN (1)	CN1085206C (no)
AT (2)	ATE326221T1 (no)
AU (1)	AU737802C (no)
BR (1)	BR9807333B1 (no)
CA (1)	CA2279319C (no)
CZ (1)	CZ299765B6 (no)
DE (2)	DE69834590T2 (no)
DK (2)	DK0960105T3 (no)
ES (2)	ES2264078T3 (no)
GB (1)	GB2325225B (no)
HU (1)	HUP0002303A3 (no)
ID (1)	ID22342A (no)
IL (1)	IL131200A (no)
NO (1)	NO318935B1 (no)
NZ (1)	NZ336980A (no)
PL (1)	PL199135B1 (no)
PT (2)	PT960105E (no)
RU (1)	RU2189984C2 (no)
TR (1)	TR199901941T2 (no)
WO (1)	WO1998035950A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN188837B (no)	1998-05-22	2002-11-09	Torrent Pharmaceuticals Ltd
AU2002366756A1 (en) *	2001-12-20	2003-07-09	Alangudi Sankaranarayanan	Use of benzofuroxan derivatives as antiplatelet agents
PL378366A1 (pl) *	2003-01-13	2006-04-03	Cortex Pharmaceuticals, Inc.	Sposób leczenia osłabienia funkcji poznawczych spowodowanego deprywacją snu i stresem
DK1636215T3 (da) *	2003-05-23	2008-06-02	Basilea Pharmaceutica Ag	Furazanobenzimidazoler
EP1715863B1 (en) *	2004-01-26	2012-05-09	Cortex Pharmaceuticals, Inc.	Enhancement of ampakine-induced facilitation of synaptic responses by cholinesterase inhibitors
MX2009002180A (es) *	2006-08-31	2009-06-05	Univ Alberta	Metodo de inhibicion de la depresion respiratoria mediante el uso de moduladores alostericos positivos del receptor ampa.
EP2144506B1 (en) *	2007-01-03	2011-10-05	Cortex Pharmaceuticals, Inc.	3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
US20100041647A1 (en) *	2007-01-03	2010-02-18	Cortex Pharmaceuticals, Inc.	3-Substituted-[1,2,3]-Benzotriazinone compounds for enhancing glutamatergic synaptic responses
TW200911768A (en) *	2007-05-17	2009-03-16	Cortex Pharma Inc	Di-substituted amides for enhancing glutamatergic synaptic responses
KR20100051678A (ko)	2007-08-10	2010-05-17	코텍스 파마슈티칼스, 인크.	글루타메이트성 시냅스 반응을 향상시키기 위한 비시클릭 아미드
US8119632B2 (en)	2007-08-10	2012-02-21	Cortex Pharmaceuticals, Inc.	Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US8071914B2 (en) *	2007-12-26	2011-12-06	Noboru Oshima	Heating apparatus
WO2010054336A2 (en) *	2008-11-10	2010-05-14	The Regents Of The University Of California	Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
SG173168A1 (en) *	2009-02-02	2011-08-29	Cortex Pharma Inc	Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US20130058915A1 (en)	2010-03-02	2013-03-07	Children's Medica Center Corporation	Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
US20110257186A1 (en) *	2010-04-15	2011-10-20	Staubli Ursula V	Compositions and methods for treating visual disorders
EP2701727B1 (en)	2011-03-04	2019-05-08	The Regents of The University of California	Locally released growth factors to mediate motor recovery after stroke
CN102633731B (zh) *	2012-03-13	2014-04-30	四川大学华西医院	6-喹喔啉甲酸酰胺化合物、制备方法和应用
KR101421032B1 (ko) *	2012-12-28	2014-07-22	주식회사 레고켐 바이오사이언스	(2-메틸-1-(3-메틸벤질)-1Ｈ-벤조[d]이미다졸-5일)(피페리딘-5-일)메탄온의 제조방법
CA2915405A1 (en)	2013-06-13	2014-12-18	Veroscience Llc	Compositions and methods for treating metabolic disorders
CN107286114B (zh)	2016-04-13	2020-08-18	中国人民解放军军事医学科学院毒物药物研究所	Ampa受体增效剂的脑靶向前药及其医药用途

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US3981864A (en) *	1973-09-08	1976-09-21	Eisai Co., Ltd.	1,3-Benzodioxol derivatives
FR2499991A1 (fr) *	1981-02-19	1982-08-20	Sandoz Sa	Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US4420485A (en) *	1982-09-29	1983-12-13	Hoechst-Roussel Pharmaceuticals Inc.	1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
SU1657189A1 (ru) *	1988-05-23	1991-06-23	Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср	Способ коррекции апато-абулических состо ний при шизофрении
SU1587050A1 (ru) *	1988-12-23	1990-08-23	Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского	Производные (7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амина в качестве промежуточных продуктов в синтезе 2-[(7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амино]-5-бром-N-(4-хлорфенил)бензамида, обладающего антигельминтной активностью
US5112824A (en) *	1989-12-08	1992-05-12	Merck & Co., Inc.	Benzofuran compounds as class III antiarrhythmic agents
US5032604A (en) *	1989-12-08	1991-07-16	Merck & Co., Inc.	Class III antiarrhythmic agents
IL96507A0 (en) *	1989-12-08	1991-08-16	Merck & Co Inc	Nitrogen-containing spirocycles and pharmaceutical compositions containing them
NZ255097A (en) *	1992-07-24	2001-04-27	Univ California	Heterocyclic derivatives (such as 1-(1,4-bgenzodioxan-5-ylcarbonyl)-1,2,3,6-tetrahydropyridine) and medicaments that enhance synaptic responses
DK0709384T3 (da) *	1994-10-31	1999-08-23	Merck Patent Gmbh	Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder
US5650409A (en) *	1995-06-02	1997-07-22	Cortex Pharmaceuticals, Inc.	Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) *	1996-04-03	1998-04-07	The Regents Of The University Of California	Benzoxazines for enhancing synaptic response
US5985871A (en)	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response

1997
- 1997-02-13 US US08/800,108 patent/US6110935A/en not_active Expired - Lifetime
1998
- 1998-02-13 PT PT98906358T patent/PT960105E/pt unknown
- 1998-02-13 NZ NZ336980A patent/NZ336980A/xx not_active IP Right Cessation
- 1998-02-13 RU RU99119488/04A patent/RU2189984C2/ru not_active IP Right Cessation
- 1998-02-13 DK DK98906358T patent/DK0960105T3/da active
- 1998-02-13 BR BRPI9807333-8A patent/BR9807333B1/pt not_active IP Right Cessation
- 1998-02-13 ES ES04075259T patent/ES2264078T3/es not_active Expired - Lifetime
- 1998-02-13 DK DK04075259T patent/DK1428534T3/da active
- 1998-02-13 EP EP04075259A patent/EP1428534B1/en not_active Expired - Lifetime
- 1998-02-13 PT PT04075259T patent/PT1428534E/pt unknown
- 1998-02-13 AT AT04075259T patent/ATE326221T1/de active
- 1998-02-13 CN CN98802541A patent/CN1085206C/zh not_active Expired - Fee Related
- 1998-02-13 WO PCT/US1998/002713 patent/WO1998035950A1/en not_active Application Discontinuation
- 1998-02-13 PL PL335058A patent/PL199135B1/pl not_active IP Right Cessation
- 1998-02-13 EP EP98906358A patent/EP0960105B1/en not_active Expired - Lifetime
- 1998-02-13 AU AU61599/98A patent/AU737802C/en not_active Ceased
- 1998-02-13 DE DE69834590T patent/DE69834590T2/de not_active Expired - Lifetime
- 1998-02-13 ID IDW990855A patent/ID22342A/id unknown
- 1998-02-13 AT AT98906358T patent/ATE266649T1/de active
- 1998-02-13 US US09/355,139 patent/US6313115B1/en not_active Expired - Fee Related
- 1998-02-13 CZ CZ0279599A patent/CZ299765B6/cs not_active IP Right Cessation
- 1998-02-13 GB GB9809221A patent/GB2325225B/en not_active Expired - Fee Related
- 1998-02-13 JP JP53589698A patent/JP4446023B2/ja not_active Expired - Fee Related
- 1998-02-13 CA CA002279319A patent/CA2279319C/en not_active Expired - Fee Related
- 1998-02-13 KR KR1019997007369A patent/KR100544295B1/ko not_active Expired - Fee Related
- 1998-02-13 IL IL13120098A patent/IL131200A/xx not_active IP Right Cessation
- 1998-02-13 DE DE69823803T patent/DE69823803T2/de not_active Expired - Lifetime
- 1998-02-13 HU HU0002303A patent/HUP0002303A3/hu unknown
- 1998-02-13 TR TR1999/01941T patent/TR199901941T2/xx unknown
- 1998-02-13 ES ES98906358T patent/ES2221152T3/es not_active Expired - Lifetime
1999
- 1999-08-04 NO NO19993768A patent/NO318935B1/no not_active IP Right Cessation
2001
- 2001-04-27 US US09/845,128 patent/US6730677B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR9807333B1 (pt)	2011-10-18
ES2264078T3 (es)	2006-12-16
DK1428534T3 (da)	2006-06-12
CA2279319A1 (en)	1998-08-20
AU6159998A (en)	1998-09-08
US6110935A (en)	2000-08-29
CZ299765B6 (cs)	2008-11-19
DE69834590T2 (de)	2007-04-26
DK0960105T3 (da)	2004-08-30
EP0960105A1 (en)	1999-12-01
NZ336980A (en)	2000-08-25
US6730677B2 (en)	2004-05-04
PL199135B1 (pl)	2008-08-29
NO318935B1 (no)	2005-05-30
KR20000071082A (ko)	2000-11-25
KR100544295B1 (ko)	2006-01-23
PL335058A1 (en)	2000-03-27
EP1428534B1 (en)	2006-05-17
BR9807333A (pt)	2000-04-18
ID22342A (id)	1999-09-30
WO1998035950A1 (en)	1998-08-20
PT960105E (pt)	2004-09-30
EP0960105B1 (en)	2004-05-12
US20020055508A1 (en)	2002-05-09
ATE266649T1 (de)	2004-05-15
GB2325225B (en)	1999-03-03
AU737802B2 (en)	2001-08-30
GB9809221D0 (no)	1998-07-01
AU737802C (en)	2005-05-12
HUP0002303A3 (en)	2002-09-30
TR199901941T2 (xx)	1999-12-21
CN1085206C (zh)	2002-05-22
NO993768D0 (no)	1999-08-04
CA2279319C (en)	2008-08-05
PT1428534E (pt)	2006-07-31
IL131200A (en)	2005-06-19
ATE326221T1 (de)	2006-06-15
JP4446023B2 (ja)	2010-04-07
DE69823803D1 (de)	2004-06-17
DE69823803T2 (de)	2005-04-14
GB2325225A (en)	1998-11-18
IL131200A0 (en)	2001-01-28
CN1247534A (zh)	2000-03-15
ES2221152T3 (es)	2004-12-16
CZ279599A3 (cs)	2000-01-12
US6313115B1 (en)	2001-11-06
GB2325225A8 (en)	1999-02-17
DE69834590D1 (de)	2006-06-22
RU2189984C2 (ru)	2002-09-27
JP2001512459A (ja)	2001-08-21
EP1428534A1 (en)	2004-06-16
HUP0002303A2 (hu)	2001-04-28

Publication	Publication Date	Title
NO993768L (no)	1999-09-23	Benzofuranforbindelser som forbedrer AMPA-reseptoraktivitet
AU2427497A (en)	1997-10-22	Benzoxazines for enhancing synaptic response
DE69811363D1 (de)	2003-03-20	Piperazin-derivate und ihre verwendung als entzündungshemmende mittel
DE60024588D1 (de)	2006-01-12	Substituierte porphyrine und deren therapeutische verwendungen
PT839134E (pt)	2004-07-30	Benzoilpiperidinas/pirrolidinas para melhoramento da resposta sinaptica
BR0015416A (pt)	2002-07-16	Composições contendo derivados do ácido hidroxieicosa tetraenóico e métodos de uso no tratamento de distúrbios de olhos secos
DK1054673T3 (da)	2004-07-05	Benzoxazinforbindelser til forstærkelse af synaptisk reaktion
MX232591B (es)	2005-12-02	Procedimiento para tratar infecciones oculares con azitromicina
ATE215374T1 (de)	2002-04-15	Wässrige, haltbare suspension von mesalazin zum topischen gebrauch
BR9612074A (pt)	1999-03-30	Novos 4-(1h-benzimidazol-2-il)(1,4) diazepanos substituidos úteis para o tratamento de doenças alérgicas
DK1067935T3 (da)	2003-11-24	Acylbenzoxaziner til forstærkning af synaptisk(e) reaktion(er)
DK0435177T3 (da)	1994-11-21	4-Benzyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-oner samt deres anvendelse som antikonvulsive midler
EA200400584A1 (ru)	2005-02-24	Соединения карбонилбензоксазина для усиления глутаматергических синаптических ответов
BR0015402A (pt)	2002-06-25	Derivados de ácido 15-hidroxieicosatetraenóico de cadeia Èmega modificada e métodos de seu uso para o tratamento de olho seco
PT889044E (pt)	2005-01-31	Derivados do 5-(heteroaril)alquil-3-oxo-pirido-(1,2-a)benzimidazole-4-carboxamida (pbi) uteis no tratamento de perturbacoes do sistema nervoso central

Legal Events

Date	Code	Title	Description
2012-10-01	MM1K	Lapsed by not paying the annual fees