AR014110A1 - Compuestos de 2-aminopiridinas, composiciones farmaceuticas, procedimiento de tratamiento, prevencion e inhibicion - Google Patents
Compuestos de 2-aminopiridinas, composiciones farmaceuticas, procedimiento de tratamiento, prevencion e inhibicionInfo
- Publication number
- AR014110A1 AR014110A1 ARP980104224A ARP980104224A AR014110A1 AR 014110 A1 AR014110 A1 AR 014110A1 AR P980104224 A ARP980104224 A AR P980104224A AR P980104224 A ARP980104224 A AR P980104224A AR 014110 A1 AR014110 A1 AR 014110A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- ring
- amino
- substituents
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de formula (I) en la que el anillo A es un anillo condensado de 5-7 eslabones, saturado o insaturado, en el que de cero a dos de loseslabones del anillo son heteroátomos seleccionados independientemente de nitrogeno, oxígeno y azufre, con la condicion de que dos miembros adyacentesdel anillo no puedan ser heteroátomos; X es oxígeno o un enlace; n es un numero entero de dos a seis; y R1 y R2 se seleccionan independientemente de alquiloC1-6, arilo, tetrahidronaftaleno y aralquilo, en los que el citado arilo y el radical arilo del citado aralquilo son fenilo o naftilo, y el resto alquilo eslineal o ramificado y contiene de 1 a 6 átomos de carbono, y en los que el citado alquilo C1-6, el citado arilo, el citado tetrahidronaftaleno y el restoarilo del citado aralquilo pueden estar sustituidos opcionalmente con uno a tres sustituyentes, preferiblemente con cero a dos sustituyentes, seleccionadosindependientemente de halo (por ejemplo, cloro, fluoro, bromo, yodo), nitro, hidroxi, ciano, amino, alcoxi C1-4 y (alquil C1-4)amino; o R1 y R2 forman,junto con el nitrogeno al que están unidos, un anillo de piperazina, piperidina o pirrolidina o un anillo azabicíclico que contiene de 6 a 14 eslabones, 1 a 3de los cuales son nitrogeno y el resto de los cuales son carbono; y en los que los citados anillos de piperazina, azetidina, piperidina y pirrolidina puedenestar sustituidos opcionalmente con uno o más sustituyentes, preferiblemente con cero a dos sustituyentes, seleccionados independientemente de alquilo C1-6,amino, (alquil C1-6)amino, di(alquil C1-6)amino, anillos heterocíclicos de 5-6 eslabones fenilsustituidos que contienen de 1 a 4 átomos de nitrogeno en losanillos, benzoílo, benzoilmetilo, bencilcarbonilo, fenilaminocarbonilo, feniletilo y fenoxicarbonilo, y en los que los restos de fenilo de cualquiera
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5709497P | 1997-08-27 | 1997-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR014110A1 true AR014110A1 (es) | 2001-02-07 |
Family
ID=22008463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104224A AR014110A1 (es) | 1997-08-27 | 1998-08-25 | Compuestos de 2-aminopiridinas, composiciones farmaceuticas, procedimiento de tratamiento, prevencion e inhibicion |
Country Status (40)
| Country | Link |
|---|---|
| EP (1) | EP1007520B1 (es) |
| JP (1) | JP3411271B2 (es) |
| KR (1) | KR100367277B1 (es) |
| CN (1) | CN1268133A (es) |
| AP (1) | AP1213A (es) |
| AR (1) | AR014110A1 (es) |
| AT (1) | ATE248161T1 (es) |
| AU (1) | AU8458898A (es) |
| BG (1) | BG104138A (es) |
| BR (1) | BR9811555A (es) |
| CA (1) | CA2296313C (es) |
| CO (1) | CO4970728A1 (es) |
| DE (1) | DE69817584T2 (es) |
| DK (1) | DK1007520T3 (es) |
| DZ (1) | DZ2594A1 (es) |
| EA (1) | EA003839B1 (es) |
| ES (1) | ES2203976T3 (es) |
| GT (1) | GT199800128A (es) |
| HN (1) | HN1998000118A (es) |
| HR (1) | HRP980470A2 (es) |
| HU (1) | HUP0003700A3 (es) |
| ID (1) | ID24087A (es) |
| IL (1) | IL133958A0 (es) |
| IS (1) | IS5344A (es) |
| MA (1) | MA26537A1 (es) |
| NO (1) | NO20000958L (es) |
| NZ (1) | NZ502281A (es) |
| OA (1) | OA11288A (es) |
| PA (1) | PA8456901A1 (es) |
| PE (1) | PE106599A1 (es) |
| PL (1) | PL338987A1 (es) |
| PT (1) | PT1007520E (es) |
| SK (1) | SK1402000A3 (es) |
| TN (1) | TNSN98154A1 (es) |
| TR (1) | TR200000535T2 (es) |
| UA (1) | UA55461C2 (es) |
| UY (1) | UY25158A1 (es) |
| WO (1) | WO1999010339A1 (es) |
| YU (1) | YU10900A (es) |
| ZA (1) | ZA987726B (es) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| NZ508101A (en) | 1998-04-10 | 2002-12-20 | Japan Tobacco Inc | Amidine compounds useful as factor Xa inhibitors and as anticoagulants |
| ES2235475T3 (es) * | 1998-06-03 | 2005-07-01 | Pfizer Products Inc. | 2-aminopiridinas que contienen sustituyentes de anillos condensados como inhibidores de oxido nitrico sintasa. |
| AP2001002067A0 (en) * | 1998-08-11 | 2001-03-31 | Pfizer Prod Inc | New pharmaceutical uses for nos inhibitors. |
| DK1155000T3 (da) | 1999-02-25 | 2003-10-13 | Pfizer Prod Inc | 2-aminopyridiner som indeholder sammensluttede ringsubstituenser |
| GB0004149D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004152D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel compounds |
| GB0004153D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| GB0004151D0 (en) * | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| FR2805818B1 (fr) * | 2000-03-03 | 2002-04-26 | Aventis Pharma Sa | Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant |
| JP2004506621A (ja) * | 2000-08-16 | 2004-03-04 | ファルマシア・アンド・アップジョン・カンパニー | 嗜癖障害治療用の化合物 |
| MXPA03010435A (es) | 2001-05-15 | 2004-03-09 | Hoffmann La Roche | Derivados de oxazol acido carboxilico sustituidos para uso como activadores de proliferacion del peroximosa(ppar-alfa y gama) en el tratamiento de diabetes. |
| SE0102640D0 (sv) | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| DE10159922A1 (de) * | 2001-12-06 | 2003-06-26 | Gruenenthal Gmbh | Substituierte 2-Pyrrolidin-2-yl-1H-indol-Derivate |
| WO2004005266A1 (en) | 2002-07-03 | 2004-01-15 | F. Hoffmann-La Roche Ag | Oxazole derivatives and their use as insulin sensitizers |
| DE60318860T2 (de) * | 2002-08-14 | 2008-05-21 | Neurosearch A/S | Chinucledin - derivate und deren verwendung |
| EP1537091B1 (en) | 2002-08-30 | 2010-10-06 | F. Hoffmann-La Roche AG | Novel 2-arylthiazole compounds as pparalpha and ppargamma agonists |
| PT1539746E (pt) | 2002-09-12 | 2007-02-28 | Hoffmann La Roche | Compostos de ácido 1h-indol-5-propiónico, substituído em n, como agonistas de ppar (receptores activados dos proliferadores de peroxissoma), úteis para o tratamento de diabetes |
| US20040092741A1 (en) * | 2002-11-08 | 2004-05-13 | Pfizer Inc | Substituted pyridines via boronic acid coupling |
| ATE405560T1 (de) | 2002-11-25 | 2008-09-15 | Hoffmann La Roche | Indolderivaten |
| US7655657B2 (en) | 2003-12-22 | 2010-02-02 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| WO2006065233A1 (en) * | 2004-12-10 | 2006-06-22 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| US7160876B2 (en) * | 2003-12-22 | 2007-01-09 | Abbott Laboratories | Fused bicycloheterocycle substituted quinuclidine derivatives |
| WO2006010040A2 (en) * | 2004-07-09 | 2006-01-26 | Glaxo Group Limited | Antibacterial agents |
| WO2009029617A1 (en) * | 2007-08-27 | 2009-03-05 | Kalypsys, Inc. | Diarylamine-substituted quinolones useful as inducible nitric oxide synthase inhibitors |
| AR068032A1 (es) * | 2007-08-27 | 2009-10-28 | Kalypays Inc | Quinolonas sustituidas con heterociclicos utiles como inhibidores de oxido nitrico sintetasa |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
| DE102008054141A1 (de) | 2008-10-31 | 2010-05-06 | Merck Patent Gmbh | Neue Materialien für organische Elektrolumineszenzvorrichtungen |
| DE102009033371A1 (de) | 2009-07-16 | 2011-05-12 | Merck Patent Gmbh | Materialien für elektronische Vorrichtungen |
| WO2014138460A1 (en) | 2013-03-07 | 2014-09-12 | Northwestern University | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors |
| CN104725249B (zh) * | 2013-12-20 | 2019-02-12 | 广东东阳光药业有限公司 | 苄胺类衍生物及其在药物上的应用 |
| US9951014B2 (en) | 2014-11-04 | 2018-04-24 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| CN106478376A (zh) * | 2016-10-08 | 2017-03-08 | 贵州大学 | 一种4‑氟萘‑1‑醇的制备工艺 |
| JP7536016B2 (ja) * | 2018-12-17 | 2024-08-19 | ゴーダーヴァリ バイオリファイナリーズ リミテッド | 無制御細胞成長の阻害用の化合物 |
| US12213973B2 (en) | 2021-10-18 | 2025-02-04 | Northwestern University | Bacterial nitric oxide synthase inhibitors |
| CN114560779B (zh) * | 2022-01-25 | 2024-06-25 | 杭州华东医药集团浙江华义制药有限公司 | 一种米拉贝隆关键中间体的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT400845B (de) * | 1993-12-06 | 1996-03-25 | Chem Pharm Forsch Gmbh | Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung |
| AU4515696A (en) | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| JPH08311028A (ja) * | 1995-05-17 | 1996-11-26 | Japan Tobacco Inc | ２−アミノピリジン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤 |
| JPH09132529A (ja) * | 1995-11-09 | 1997-05-20 | Ono Pharmaceut Co Ltd | 一酸化窒素合成酵素阻害剤 |
| ES2214604T3 (es) | 1996-03-29 | 2004-09-16 | Pfizer Inc. | Derivados de la 6-fenilpiridil-2-amina. |
| HN1997000027A (es) * | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
-
1998
- 1998-07-29 HN HN1998000118A patent/HN1998000118A/es unknown
- 1998-08-10 GT GT199800128A patent/GT199800128A/es unknown
- 1998-08-10 PA PA19988456901A patent/PA8456901A1/es unknown
- 1998-08-11 NZ NZ502281A patent/NZ502281A/xx unknown
- 1998-08-11 BR BR9811555-3A patent/BR9811555A/pt not_active Application Discontinuation
- 1998-08-11 YU YU10900A patent/YU10900A/sh unknown
- 1998-08-11 CN CN98808577A patent/CN1268133A/zh active Pending
- 1998-08-11 DE DE69817584T patent/DE69817584T2/de not_active Expired - Fee Related
- 1998-08-11 AU AU84588/98A patent/AU8458898A/en not_active Abandoned
- 1998-08-11 WO PCT/IB1998/001229 patent/WO1999010339A1/en not_active Application Discontinuation
- 1998-08-11 AT AT98935249T patent/ATE248161T1/de not_active IP Right Cessation
- 1998-08-11 SK SK140-2000A patent/SK1402000A3/sk unknown
- 1998-08-11 DK DK98935249T patent/DK1007520T3/da active
- 1998-08-11 ES ES98935249T patent/ES2203976T3/es not_active Expired - Lifetime
- 1998-08-11 ID IDW20000198A patent/ID24087A/id unknown
- 1998-08-11 IL IL13395898A patent/IL133958A0/xx unknown
- 1998-08-11 EA EA200000171A patent/EA003839B1/ru not_active IP Right Cessation
- 1998-08-11 HU HU0003700A patent/HUP0003700A3/hu unknown
- 1998-08-11 CA CA002296313A patent/CA2296313C/en not_active Expired - Fee Related
- 1998-08-11 TR TR2000/00535T patent/TR200000535T2/xx unknown
- 1998-08-11 EP EP98935249A patent/EP1007520B1/en not_active Expired - Lifetime
- 1998-08-11 KR KR10-2000-7001017A patent/KR100367277B1/ko not_active Expired - Fee Related
- 1998-08-11 PL PL98338987A patent/PL338987A1/xx unknown
- 1998-08-11 JP JP2000507668A patent/JP3411271B2/ja not_active Expired - Fee Related
- 1998-08-11 PT PT98935249T patent/PT1007520E/pt unknown
- 1998-08-24 PE PE1998000772A patent/PE106599A1/es not_active Application Discontinuation
- 1998-08-25 AR ARP980104224A patent/AR014110A1/es not_active Application Discontinuation
- 1998-08-26 MA MA25229A patent/MA26537A1/fr unknown
- 1998-08-26 DZ DZ980204A patent/DZ2594A1/xx active
- 1998-08-26 ZA ZA9807726A patent/ZA987726B/xx unknown
- 1998-08-26 TN TNTNSN98154A patent/TNSN98154A1/fr unknown
- 1998-08-26 UY UY25158A patent/UY25158A1/es unknown
- 1998-08-27 AP APAP/P/1998/001330A patent/AP1213A/en active
- 1998-08-27 HR HR60/057,094A patent/HRP980470A2/hr not_active Application Discontinuation
- 1998-08-27 CO CO98049140A patent/CO4970728A1/es unknown
- 1998-11-08 UA UA2000010298A patent/UA55461C2/uk unknown
-
2000
- 2000-01-14 IS IS5344A patent/IS5344A/is unknown
- 2000-02-08 BG BG104138A patent/BG104138A/xx unknown
- 2000-02-18 OA OA1200000037A patent/OA11288A/en unknown
- 2000-02-25 NO NO20000958A patent/NO20000958L/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR014110A1 (es) | Compuestos de 2-aminopiridinas, composiciones farmaceuticas, procedimiento de tratamiento, prevencion e inhibicion | |
| AR006391A1 (es) | Compuesto de 6-fenilpiridil-2-amina y composiciones farmaceuticas del mismo | |
| AR010331A1 (es) | Compuestos derivados de 6-fenilpiridil-2-amina utiles como inhibidores nos, composiciones farmaceuticas que comprenden dichos compuestos, y metodosde tratamiento utilizando dichos compuestos. | |
| LU91196I2 (fr) | Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO). | |
| CO4650033A1 (es) | Derivados de lactama con actividad selectiva agonista y antagonista de receptores de serotonina 1 (5ht) y composiciones farmaceuticas que los contienen . | |
| MX9300031A (es) | Derivados de piperazina, procedimiento para su preparacion y composicion farmaucetica que los contiene. | |
| MX9206939A (es) | Derivados de piperazina, procedimiento para su preparacion y composicion farmaceutica que los comprende | |
| DK1052254T3 (da) | Nitrogen-holdig heterocykliske derivater og medicin deraf | |
| DK419086A (da) | Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler | |
| ES2095860T3 (es) | Derivados de 4-(1'-oxociclohex-2'-il)azetidin-2-ona. | |
| SE0300956L (sv) | Stabilisatorblandningar | |
| ES2058292T3 (es) | Derivados de indol. | |
| PT90623A (pt) | Processo para a preparacao de n-heterociclil-4-guanilalquil-benzamidas uteis como inibidores de protease | |
| ES2172173T3 (es) | 2-aminopiridinas con sustituyentes alcoxi ramificados como inhibidores de la nos. | |
| DK99691A (da) | Dopamin-beta-hydroxylase-inhibitorer og fremgangsmaade til deres fremstilling | |
| MX9302948A (es) | Imidazolinonas fungicidas y composicion fungicida que las contiene. | |
| MX9202749A (es) | Compuesto amidino, proceso para su obtencion y composicion farmaceutica que los contiene. | |
| PE20040531A1 (es) | Derivados de isoindolona, proceso de preparacion, compuestos intermedios de este proceso y composiciones farmaceuticas que los contienen | |
| UY25211A1 (es) | Inhibidores de isoquinolinilguanidina uroquinasa | |
| HUP9801072A2 (hu) | Szubsztituált 6-és 7-amino-tetrahidro-izokinolin-karbonsav-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
| BG101484A (bg) | Използване на естери на 3-арилакрилова киселина като средства за защита от светлина и като стабилизатори на нежив органичен материал | |
| CO2025003311A2 (es) | Inhibidores heterocíclicos de sik | |
| PT97766A (pt) | Processo depreparacao de derivados de isocromano e de composicoes farmaceuticas que os contem | |
| BG100954A (bg) | Нови производни на хидроксамови киселини, фармацевтични състави на тяхна основа и метод за получаването им | |
| ES2137929T3 (es) | Derivados de esteres penem antibacterianos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |