AR043205A1 - Derivados de benceno sustituidos con trimeros macrociclicos - Google Patents
Derivados de benceno sustituidos con trimeros macrociclicosInfo
- Publication number
- AR043205A1 AR043205A1 ARP040100490A ARP040100490A AR043205A1 AR 043205 A1 AR043205 A1 AR 043205A1 AR P040100490 A ARP040100490 A AR P040100490A AR P040100490 A ARP040100490 A AR P040100490A AR 043205 A1 AR043205 A1 AR 043205A1
- Authority
- AR
- Argentina
- Prior art keywords
- chz1
- chz2
- atom
- meaning
- trimeros
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910021645 metal ion Inorganic materials 0.000 abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 101150089330 CHZ1 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Complejos metálicos apropiados como sustancias de contraste de la fórmula general (1). A1 representa los radicales: -CONR1-(CH2)n-NR2-(CO-CHZ1-NH)m-CO-CHZ2-K, -CONR1-(CH2)p-(CONR2CH2)m-CHOH-CH2-K, -CH2-O-CH2)p-CHOH-CH2-K, -CH2-O-(CH2)n-NR1-(CO-CHZ1-NH)m-CO-CHZ2-K, -CH2-NR1-CO-(CHZ1-NH-CO)m-CHZ2-K, A2 tiene el mismo significado que A1 o en el caso que A1 tenga el significado mencionado en primer término también puede ser el radical -NR1-CO-(NR1)m-(CH2)p-NR2-(CO-CHZ1-NH)m-CO-CHZ2-K, donde R1 y R2 son independientemente un átomo de H, un grupo alquilo C1-2 o un grupo alquilo C1-12 monohidroxi, Z1 y Z2 son independientemente entre sí un átomo de H o un grupo metilo, n es el número 2-4, m es el número 0 o 1 y p es el número 1-4, K representa un macrociclo de la fórmula (2) done X tiene el significado de un átomo de H o un equivalente de ión metálico de número atómico 20-29, 39, 42, 44 o 57-83, con la condición de que por lo menos dos X representan equivalentes de iones metálicos y que ls grupos carboxi libres que puedan estar presentes puedan estar presentes como sales de bases orgánicas y/o inorgánicas o aminoácidos o amidas de aminoácidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10307759A DE10307759B3 (de) | 2003-02-19 | 2003-02-19 | Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR043205A1 true AR043205A1 (es) | 2005-07-20 |
Family
ID=32891780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100490A AR043205A1 (es) | 2003-02-19 | 2004-02-18 | Derivados de benceno sustituidos con trimeros macrociclicos |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1594851A1 (es) |
| JP (1) | JP2006514664A (es) |
| KR (1) | KR20050105474A (es) |
| CN (1) | CN1753878A (es) |
| AR (1) | AR043205A1 (es) |
| AU (1) | AU2003290032B2 (es) |
| BR (1) | BR0318125A (es) |
| CA (1) | CA2516467A1 (es) |
| CR (1) | CR7937A (es) |
| DE (1) | DE10307759B3 (es) |
| EC (1) | ECSP056026A (es) |
| MX (1) | MXPA05008781A (es) |
| NO (1) | NO20054291L (es) |
| RU (1) | RU2005128834A (es) |
| WO (1) | WO2004074267A1 (es) |
| ZA (1) | ZA200507437B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| DE102004023093B3 (de) | 2004-05-05 | 2006-03-02 | Schering Ag | Trimere makrocyclisch substituierte Halogen-Benzolderivate |
| DE102004026103A1 (de) * | 2004-05-25 | 2005-12-22 | Schering Ag | Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| DE102007058220A1 (de) | 2007-12-03 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | Dimere macrocyclisch substituierte Benzolderivate |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| JP6124078B2 (ja) * | 2010-08-26 | 2017-05-10 | ツイ，クンユァン | 巨大環状脂肪族化合物及びその応用 |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| CN104721844B (zh) * | 2015-02-02 | 2017-11-03 | 湖北大学 | 一种新型ct，mri，稀土荧光三功能微球及其制备方法和应用 |
| CN104672259B (zh) * | 2015-02-02 | 2017-04-05 | 湖北大学 | 一种含碘稀土铕(ⅲ)配合物及其制备方法和应用 |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| CN105254529B (zh) * | 2015-09-21 | 2017-05-31 | 西南石油大学 | 一种树形席夫碱缓蚀剂的制备方法 |
| JP7034160B2 (ja) | 2016-11-28 | 2022-03-11 | バイエル・ファルマ・アクティエンゲゼルシャフト | 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物 |
| CN107445911B (zh) * | 2017-06-19 | 2019-07-05 | 南京科技职业学院 | 一种二核含钆磁共振对比剂及其制备与应用 |
| CN113164628A (zh) | 2018-11-23 | 2021-07-23 | 拜耳股份有限公司 | 造影介质制剂及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324503A (en) * | 1992-02-06 | 1994-06-28 | Mallinckrodt Medical, Inc. | Iodo-phenylated chelates for x-ray contrast |
| DE69425572T2 (de) * | 1993-06-02 | 2001-04-26 | Bracco Spa | Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel |
| FR2736051B3 (fr) * | 1995-06-29 | 1997-09-26 | Guerbet Sa | Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique |
| FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
-
2003
- 2003-02-19 DE DE10307759A patent/DE10307759B3/de not_active Expired - Fee Related
- 2003-12-12 MX MXPA05008781A patent/MXPA05008781A/es active IP Right Grant
- 2003-12-12 RU RU2005128834/04A patent/RU2005128834A/ru not_active Application Discontinuation
- 2003-12-12 AU AU2003290032A patent/AU2003290032B2/en not_active Expired - Fee Related
- 2003-12-12 CN CNA2003801098702A patent/CN1753878A/zh active Pending
- 2003-12-12 BR BR0318125-1A patent/BR0318125A/pt not_active IP Right Cessation
- 2003-12-12 KR KR1020057015199A patent/KR20050105474A/ko not_active Ceased
- 2003-12-12 EP EP03782386A patent/EP1594851A1/de not_active Withdrawn
- 2003-12-12 CA CA002516467A patent/CA2516467A1/en not_active Abandoned
- 2003-12-12 JP JP2004568408A patent/JP2006514664A/ja not_active Withdrawn
- 2003-12-12 WO PCT/EP2003/014149 patent/WO2004074267A1/de active Application Filing
-
2004
- 2004-02-18 AR ARP040100490A patent/AR043205A1/es unknown
-
2005
- 2005-08-09 CR CR7937A patent/CR7937A/es not_active Application Discontinuation
- 2005-09-15 ZA ZA200507437A patent/ZA200507437B/en unknown
- 2005-09-16 NO NO20054291A patent/NO20054291L/no not_active Application Discontinuation
- 2005-09-19 EC EC2005006026A patent/ECSP056026A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR0318125A (pt) | 2006-02-07 |
| EP1594851A1 (de) | 2005-11-16 |
| NO20054291D0 (no) | 2005-09-16 |
| DE10307759B3 (de) | 2004-11-18 |
| RU2005128834A (ru) | 2006-03-20 |
| ZA200507437B (en) | 2007-02-28 |
| CR7937A (es) | 2006-02-07 |
| CN1753878A (zh) | 2006-03-29 |
| NO20054291L (no) | 2005-11-17 |
| KR20050105474A (ko) | 2005-11-04 |
| JP2006514664A (ja) | 2006-05-11 |
| ECSP056026A (es) | 2006-01-27 |
| AU2003290032A1 (en) | 2004-09-09 |
| AU2003290032B2 (en) | 2009-04-23 |
| WO2004074267A1 (de) | 2004-09-02 |
| CA2516467A1 (en) | 2004-09-02 |
| MXPA05008781A (es) | 2006-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |