ATE152129T1 - Inhibitorvarianten der menschlichen protease vom kunitz-typ - Google Patents

Inhibitorvarianten der menschlichen protease vom kunitz-typ

Info

Publication number: ATE152129T1
Authority: AT; Austria
Prior art keywords: amino acid; cys; lys; acid residues; asp
Prior art date: 1992-01-07

Application number

AT93902103T

Other languages

English (en)

Inventor

Soeren Erik Bjoern

Kjeld Norris

Fanny Norris

Lars Christian Petersen

Ole Hvilsted Olsen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-07

Filing date

1993-01-07

Publication date

1997-05-15

1993-01-07 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1997-05-15 Application granted granted Critical

1997-05-15 Publication of ATE152129T1 publication Critical patent/ATE152129T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Plant Substances (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT93902103T 1992-01-07 1993-01-07 Inhibitorvarianten der menschlichen protease vom kunitz-typ ATE152129T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK9200005		1992-01-07

Publications (1)

Publication Number	Publication Date
ATE152129T1 true ATE152129T1 (de)	1997-05-15

Family

ID=8153776

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93902103T ATE152129T1 (de)	1992-01-07	1993-01-07	Inhibitorvarianten der menschlichen protease vom kunitz-typ

Country Status (16)

Country	Link
US (1)	US5629176A (de)
EP (1)	EP0621869B1 (de)
JP (1)	JPH07506334A (de)
AT (1)	ATE152129T1 (de)
AU (1)	AU671611B2 (de)
CA (1)	CA2127248A1 (de)
CZ (1)	CZ164694A3 (de)
DE (1)	DE69310141D1 (de)
FI (1)	FI943231A7 (de)
HU (1)	HUT70292A (de)
IL (1)	IL104327A0 (de)
NO (1)	NO942552L (de)
NZ (1)	NZ246567A (de)
RU (1)	RU94036776A (de)
WO (1)	WO1993014119A1 (de)
ZA (1)	ZA9398B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060134087A1 (en) *	1988-09-02	2006-06-22	Dyax Corp.	ITI-D1 Kunitz domain mutants as hNE inhibitors
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) *	1994-03-04	1998-08-18	Genentech, Inc.	Factor VIIa inhibitors from Kunitz domain proteins
ZA963619B (en)	1995-05-08	1996-11-22	Scios Inc	Protease inhibitor peptides
CA2220497A1 (en) *	1995-05-08	1996-11-14	Scios, Inc.	Kunitz type protease inhibitors
US5786328A (en) *	1995-06-05	1998-07-28	Genentech, Inc.	Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) *	1995-06-05	1998-07-14	Genentech, Inc.	Kunitz type plasma kallikrein inhibitors
US6242414B1 (en)	1995-06-07	2001-06-05	Chiron Corporation	Regulation of cytokine synthesis and release
US5736364A (en) *	1995-12-04	1998-04-07	Genentech, Inc.	Factor viia inhibitors
ES2528254T3 (es)	2002-06-07	2015-02-05	Dyax Corp.	Polipéptidos de dominio Kunitz modificado y su uso para reducir la isquemia o el inicio de una respuesta inflamatoria sistémica asociada con un procedimiento quirúrgico
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
EP1587907B1 (de) *	2003-01-07	2011-03-02	Dyax Corporation	Kunitz-domäne-bibliothek
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
EP1981519B1 (de)	2005-12-29	2017-12-27	Dyax Corp.	Proteasehemmung
AU2008289005A1 (en) *	2007-08-21	2009-02-26	Genzyme Corporation	Treatment with kallikrein inhibitors
LT2379096T (lt)	2008-12-19	2019-12-27	Baxalta GmbH	Tfpi inhibitoriai ir vartojimo būdai
AU2010203712A1 (en) *	2009-01-06	2010-07-15	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
WO2011085103A2 (en)	2010-01-06	2011-07-14	Dyax Corp.	Plasma kallikrein binding proteins
CN103025345B (zh)	2010-03-19	2016-01-20	巴克斯特国际公司	Tfpi抑制剂及使用方法
KR102502293B1 (ko)	2011-01-06	2023-02-21	다케다 파머수티컬 컴패니 리미티드	혈장 칼리크레인 결합 단백질
KR20140143191A (ko)	2012-03-21	2014-12-15	백스터 인터내셔널 인코포레이티드	Tfpi 저해제 및 사용 방법
CA2942713A1 (en)	2014-03-27	2015-10-01	Dyax Corp.	Compositions and methods for treatment of diabetic macular edema
WO2017100679A1 (en)	2015-12-11	2017-06-15	Dyax Corp.	Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3912638A1 (de) *	1989-04-18	1990-10-31	Bayer Ag	Gentechnologisch hergestellte homologe des alzheimer protease inhibitors, wirtstaemme sowie expressionsvektoren fuer ihre herstellung und ihre verwendung als arzneimittel
DE59007737D1 (de) *	1989-05-13	1995-01-05	Bayer Ag	Proteinaseninhibitoren, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel.
US5278285A (en) *	1990-02-01	1994-01-11	Bayer Aktiengesellschaft	Variant of Kunitz-type inhibitor derived from the α3-chain of human type VI collagen produced by recombinant DNA technology

1993
- 1993-01-06 IL IL104327A patent/IL104327A0/xx unknown
- 1993-01-07 WO PCT/DK1993/000002 patent/WO1993014119A1/en not_active Application Discontinuation
- 1993-01-07 CA CA002127248A patent/CA2127248A1/en not_active Abandoned
- 1993-01-07 EP EP93902103A patent/EP0621869B1/de not_active Expired - Lifetime
- 1993-01-07 FI FI943231A patent/FI943231A7/fi unknown
- 1993-01-07 CZ CZ941646A patent/CZ164694A3/cs unknown
- 1993-01-07 RU RU94036776/13A patent/RU94036776A/ru unknown
- 1993-01-07 NZ NZ246567A patent/NZ246567A/en unknown
- 1993-01-07 AT AT93902103T patent/ATE152129T1/de not_active IP Right Cessation
- 1993-01-07 AU AU33457/93A patent/AU671611B2/en not_active Ceased
- 1993-01-07 HU HU9401993A patent/HUT70292A/hu unknown
- 1993-01-07 ZA ZA9398A patent/ZA9398B/xx unknown
- 1993-01-07 DE DE69310141T patent/DE69310141D1/de not_active Expired - Lifetime
- 1993-01-07 JP JP5511990A patent/JPH07506334A/ja active Pending
1994
- 1994-07-06 NO NO942552A patent/NO942552L/no unknown
- 1994-11-04 US US08/334,773 patent/US5629176A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ246567A (en)	1996-05-28
AU671611B2 (en)	1996-09-05
DE69310141D1 (de)	1997-05-28
CA2127248A1 (en)	1993-07-22
JPH07506334A (ja)	1995-07-13
EP0621869A1 (de)	1994-11-02
FI943231L (fi)	1994-07-06
HU9401993D0 (en)	1994-09-28
US5629176A (en)	1997-05-13
NO942552L (no)	1994-09-07
FI943231A0 (fi)	1994-07-06
WO1993014119A1 (en)	1993-07-22
RU94036776A (ru)	1996-09-27
EP0621869B1 (de)	1997-04-23
HUT70292A (en)	1995-09-28
IL104327A0 (en)	1993-05-13
NO942552D0 (no)	1994-07-06
FI943231A7 (fi)	1994-07-06
CZ164694A3 (en)	1994-12-15
AU3345793A (en)	1993-08-03
ZA9398B (en)	1993-08-10

Publication	Publication Date	Title
ATE152129T1 (de)	1997-05-15	Inhibitorvarianten der menschlichen protease vom kunitz-typ
ES2104121T3 (es)	1997-10-01	Variante de un inhibidor de proteasas, de tipo kunitz, de origen humano.
NO942551L (no)	1994-09-07	Humanproteaseinhibitorvariant av Kunitz-type
NO942549L (no)	1994-09-07	Humanproteaseinhibitorvariant av Kunitz-type
NZ331895A (en)	2000-07-28	Hemoglobin alpha chain polypeptide as inhibitor and stimulator of stem cell proliferation
HU9401989D0 (en)	1994-09-28	A novel human kunitz-type protease inhibitor and variants thereof
NL300013I1 (nl)	2000-10-02	Nieuwe protein met TNF-remmende werking en hun ber
ATE477020T1 (de)	2010-08-15	Prevention und verringerung von ischemia
AR006517A1 (es)	1999-09-08	Polipeptido que alcanza un total de alrededor de 30 aminoacidos; sustancia, peptidomimetico y composicion farmaceutica resultantes; usos del polipeptidoy proceso para la sintesis del polipeptido.
DK0466175T3 (da)	1998-09-07	Porcint CNP-gen og præcursor-protein
AU5963290A (en)	1991-01-17	Inhibition of the n-end rule pathway in living cells
EP0352014A3 (de)	1991-07-03	Zyklische GRF-Analoge
CY1112839T1 (el)	2016-02-10	Πεπτιδια χ-κωνοτοξινες που εχουν ενα αμινοτελικο πυρογλουταμικο οξυ
KR840007569A (ko)	1984-12-08	Grf 유사체 펩티드의 제법
ES2056753A6 (es)	1994-10-01	Un procedimiento para la produccion de un polipeptido que tiene actividad de factor quemotactico de monocitos humanos.
KR920700225A (ko)	1992-02-19	Grf 유사체 viia
EP1778724B8 (de)	2011-01-26	Antiangiogene peptide
ES2171157T3 (es)	2002-09-01	Gen recombinante codificante para una proteina con actividad endoquitinasa.
CA2375224A1 (en)	2000-12-28	Human antithrombin variants
AU2003259309A8 (en)	2004-01-19	Peptides having affinity for a phospholipid and uses
FR2787454B1 (fr)	2002-02-15	Inhibiteur de la topoisomerase ii
KR940703855A (ko)	1994-12-12	사람 쿠니즈형 프로테아제 저해제 변이체(a human kunitz-type protease inhibitor variant)
TH2482B (th)	1991-08-26	สารคล้ายคลึง จี อาร์ เอฟ (grf)

Legal Events

Date	Code	Title	Description
1997-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties