ATE157864T1 - Verfahren für die herstellung einer festen dispersion - Google Patents
Verfahren für die herstellung einer festen dispersionInfo
- Publication number
- ATE157864T1 ATE157864T1 AT92925333T AT92925333T ATE157864T1 AT E157864 T1 ATE157864 T1 AT E157864T1 AT 92925333 T AT92925333 T AT 92925333T AT 92925333 T AT92925333 T AT 92925333T AT E157864 T1 ATE157864 T1 AT E157864T1
- Authority
- AT
- Austria
- Prior art keywords
- drug
- producing
- solid dispersion
- polymer
- carrier
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000007962 solid dispersion Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000008342 pharmaceutical dispersion Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Colloid Chemistry (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Glanulating (AREA)
- Ceramic Products (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80965691A | 1991-12-18 | 1991-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE157864T1 true ATE157864T1 (de) | 1997-09-15 |
Family
ID=25201894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92925333T ATE157864T1 (de) | 1991-12-18 | 1992-11-18 | Verfahren für die herstellung einer festen dispersion |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US6677362B1 (de) |
| EP (1) | EP0617612B1 (de) |
| JP (1) | JP3722293B2 (de) |
| AT (1) | ATE157864T1 (de) |
| AU (1) | AU671811B2 (de) |
| CA (1) | CA2124821C (de) |
| DE (1) | DE69222182T2 (de) |
| DK (1) | DK0617612T3 (de) |
| ES (1) | ES2109377T3 (de) |
| GR (1) | GR3025501T3 (de) |
| IL (1) | IL104179A (de) |
| MX (1) | MX9207390A (de) |
| NZ (1) | NZ245483A (de) |
| PT (1) | PT101132B (de) |
| SG (1) | SG43179A1 (de) |
| WO (1) | WO1993011749A1 (de) |
| ZA (1) | ZA929789B (de) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE159426T1 (de) * | 1991-04-16 | 1997-11-15 | Nippon Shinyaku Co Ltd | Verfahren zur herstellung einer festen dispersion |
| EP0617612B1 (de) | 1991-12-18 | 1997-09-10 | Warner-Lambert Company | Verfahren für die herstellung einer festen dispersion |
| WO1995013794A1 (fr) * | 1993-11-18 | 1995-05-26 | Nippon Shinyaku Co., Ltd. | Procede pour produire une composition de medicament stable, et preparation pharmaceutique |
| SE9502244D0 (sv) * | 1995-06-20 | 1995-06-20 | Bioglan Ab | A composition and a process for the preparation thereof |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| PT1014941E (pt) | 1996-06-26 | 2009-07-08 | Univ Texas | Formulação farmacêutica extrudível por termofusão |
| AU3483497A (en) * | 1996-06-28 | 1998-01-21 | Schering Corporation | Solid solution of an antifungal agent with enhanced bioavailability |
| US20050004049A1 (en) * | 1997-03-11 | 2005-01-06 | Elan Pharma International Limited | Novel griseofulvin compositions |
| US5955475A (en) * | 1997-06-30 | 1999-09-21 | Endo Pharmaceuticals Inc. | Process for manufacturing paroxetine solid dispersions |
| HN1998000115A (es) * | 1997-08-21 | 1999-06-02 | Warner Lambert Co | Formas de dosificación farmacéuticas sólidas |
| CA2214895C (en) * | 1997-09-19 | 1999-04-20 | Bernard Charles Sherman | Improved pharmaceutical composition comprising fenofibrate |
| US6376542B1 (en) * | 1997-12-19 | 2002-04-23 | Bissell Homecare, Inc. | Aqueous miticide compositions containing benzyl benzoate |
| US6107341A (en) * | 1997-12-19 | 2000-08-22 | Bissell Homecare, Inc. | Aqueous miticide containing benzyl benzoate |
| ID28304A (id) * | 1997-12-22 | 2001-05-10 | Schering Corp | Komposisi dispersi molekular dengan ketersediaan-bio yang lebih baik |
| US6706283B1 (en) | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
| DE19913606A1 (de) * | 1999-03-25 | 2000-09-28 | Basf Ag | Pulverförmige Solubilisationshilfsstoffe für feste pharmazeutische Darreichungsformen |
| DE19916383A1 (de) * | 1999-03-31 | 2000-10-05 | Schering Ag | Pharmazeutische Zusammensetzung mit einem Extrusionsstoff |
| CA2374117A1 (en) * | 1999-05-28 | 2000-12-07 | Abbott Laboratories | Novel formulations comprising lipid-regulating agents |
| DE19929361A1 (de) * | 1999-06-25 | 2001-01-04 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
| CA2359945C (en) * | 1999-11-12 | 2011-04-26 | Abbott Laboratories | Inhibitors of crystallization in a solid dispersion |
| DE10000792A1 (de) * | 2000-01-11 | 2001-07-19 | Bernhard C Lippold | Formulierungen von Wirkstoffen in Form einer festen Dispersion |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| ES2333645T3 (es) | 2001-06-22 | 2010-02-25 | Bend Research, Inc. | Composiciones farmaceuticas de dispersiones de medicamentos y polimeros neutros. |
| IL158991A0 (en) | 2001-06-22 | 2004-05-12 | Pfizer Prod Inc | Pharmaceutical compositions comprising low-solubility and/or acid sensitive drugs and neutralized acidic polymers |
| ATE395044T1 (de) | 2002-02-01 | 2008-05-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| GB0205253D0 (en) * | 2002-03-06 | 2002-04-17 | Univ Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
| JP2005526083A (ja) * | 2002-03-14 | 2005-09-02 | ワトソン ファーマシューティカルズ, インコーポレイテッド | プロゲステロンの経口薬物送達システム |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US20050181032A1 (en) * | 2002-06-25 | 2005-08-18 | Acrux Dds Pty Ltd. | Metastable pharmaceutical compositions |
| JP5160018B2 (ja) * | 2002-06-25 | 2013-03-13 | アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド | 非晶質医薬組成物を用いる経皮送達速度調節 |
| EP1592760A4 (de) | 2003-01-31 | 2009-08-12 | Smithkline Beecham Corp | Als feste dispersionen vorliegende zusammensetzungen |
| JP4783278B2 (ja) * | 2003-02-03 | 2011-09-28 | ノバルティス アーゲー | 医薬製剤 |
| EA009985B1 (ru) | 2003-03-10 | 2008-04-28 | Никомед Гмбх | Новый способ получения рофлумиласта |
| DE602004016311D1 (de) * | 2003-04-29 | 2008-10-16 | Organon Nv | Verfahren zur verfestigung, bei welchem ein anti-lösungsmittel benutzt wird |
| PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
| CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
| GB0315012D0 (en) * | 2003-06-27 | 2003-07-30 | Leuven K U Res & Dev | Zeotiles |
| US8273371B2 (en) | 2003-06-27 | 2012-09-25 | Johan Adriaan Martens | Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs |
| ATE540671T1 (de) | 2003-08-04 | 2012-01-15 | Bend Res Inc | Pharmazeutische zusammensetzungen von adsorbaten von amorphen arzneimitteln und lipophilen mikrophasen-bildenden materialien |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US7658944B2 (en) | 2003-10-10 | 2010-02-09 | Lifecycle Pharma A/S | Solid dosage form comprising a fibrate |
| DK1691787T3 (da) * | 2003-12-04 | 2008-09-22 | Pfizer Prod Inc | Fremgangsmåde til at danne småpartikler |
| KR100629771B1 (ko) * | 2004-01-27 | 2006-09-28 | 씨제이 주식회사 | 결정성이 감소되거나 무정형화된 올티프라즈의 제조방법 |
| US20050202079A1 (en) * | 2004-03-15 | 2005-09-15 | Mylan Pharmaceuticals Inc. | Novel orally administrable formulation of nitrofurantoin and a method for preparing said formulation |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| GB2418854B (en) | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US8663694B2 (en) * | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| KR100627687B1 (ko) * | 2005-04-20 | 2006-09-25 | 주식회사 씨티씨바이오 | 시부트라민 유리염기 함유 조성물 및 이의 제조방법 |
| WO2006112649A1 (en) * | 2005-04-20 | 2006-10-26 | Ctc Bio, Inc. | Pharmaceutical composition containing sibutramine free base and manufacturing method thereof |
| DE102005023803A1 (de) * | 2005-05-19 | 2006-11-23 | Basf Ag | Verfahren zur Herstellung von festen Blends aus Polyvinylpyrrolidonen und ethoxilierten Fettsäurederivaten |
| KR20070025070A (ko) * | 2005-08-31 | 2007-03-08 | 주식회사 대웅제약 | 시부트라민 및 계면활성제를 함유하는 고체분산체 및 그의제조방법 |
| GB0612695D0 (en) * | 2006-06-27 | 2006-08-09 | Univ Gent | Process for preparing a solid dosage form |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| US20080132560A1 (en) * | 2006-11-21 | 2008-06-05 | San-Laung Chow | Solid dispersion composition |
| WO2008079629A2 (en) * | 2006-12-21 | 2008-07-03 | Boehringer Ingelheim International Gmbh | Formulations with improved bioavailability |
| WO2009087410A2 (en) * | 2008-01-11 | 2009-07-16 | Cipla Limited | Solid pharmaceutical dosage form |
| BRPI0906467C1 (pt) | 2008-01-25 | 2021-05-25 | Gruenenthal Gmbh | forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada |
| PT2273983T (pt) | 2008-05-09 | 2016-10-28 | Gruenenthal Gmbh | Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização |
| WO2011009604A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Oxidation-stabilized tamper-resistant dosage form |
| MX2012000317A (es) | 2009-07-22 | 2012-02-08 | Gruenenthal Gmbh | Forma de dosificacion de liberacion controlada extruida por fusion en caliente. |
| KR102456997B1 (ko) * | 2009-10-27 | 2022-10-19 | 루핀 리미티드 | 리팍시민의 고형 분산물 |
| CA2808219C (en) | 2010-09-02 | 2019-05-14 | Gruenenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
| CN103179954A (zh) | 2010-09-02 | 2013-06-26 | 格吕伦塔尔有限公司 | 包含阴离子聚合物的抗破碎剂型 |
| JP5999567B2 (ja) | 2010-10-20 | 2016-09-28 | ディーエスエム アイピー アセッツ ビー.ブイ. | ペンダント型親水性物質を有する生分解性組成物および関連デバイス |
| US20120277210A1 (en) * | 2010-10-29 | 2012-11-01 | Abbott Laboratories | Solid dispersions containing an apoptosis-inducing agent |
| HUE034711T2 (en) | 2011-07-29 | 2018-02-28 | Gruenenthal Gmbh | Anti-Abuse, Immediate Release Tablet |
| DK2736497T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Stød-resistent tablet, der tilvejebringer en øjeblikkelig frigivelse af et lægemiddel. |
| WO2013030789A1 (en) | 2011-08-30 | 2013-03-07 | Ranbaxy Laboratories Limited | Pharmaceutical oral solid dosage form containing a poorly water soluble pde - iv inhibitor |
| AU2013225106B2 (en) | 2012-02-28 | 2017-11-02 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| AR090695A1 (es) | 2012-04-18 | 2014-12-03 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| KR102191562B1 (ko) * | 2012-11-07 | 2020-12-15 | 에스케이바이오팜 주식회사 | 난용성 약물의 고체분산체 및 이의 제조방법 |
| US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| JP6445537B2 (ja) | 2013-05-29 | 2018-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 1個または複数の粒子を含有する改変防止(tamper−resistant)剤形 |
| MX368846B (es) | 2013-07-12 | 2019-10-18 | Gruenenthal Gmbh | Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo. |
| WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| CA2931553C (en) | 2013-11-26 | 2022-01-18 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| CA2947786A1 (en) | 2014-05-12 | 2015-11-19 | Grunenthal Gmbh | Tamper resistant immediate release capsule formulation comprising tapentadol |
| CA2949422A1 (en) | 2014-05-26 | 2015-12-03 | Grunenthal Gmbh | Multiparticles safeguarded against ethanolic dose-dumping |
| EP3227299B1 (de) | 2014-12-04 | 2021-05-26 | Merck Sharp & Dohme Corp. | Formulierung zur hemmung der effekte einer schwach sauren umgebung |
| MX2017013637A (es) | 2015-04-24 | 2018-03-08 | Gruenenthal Gmbh | Forma de dosificacion resistente a alteraciones con liberacion inmediata y resistencia contra la extraccion por solventes. |
| WO2017042325A1 (en) | 2015-09-10 | 2017-03-16 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| CN113616599B (zh) * | 2021-09-10 | 2022-11-18 | 宁夏医科大学 | 一种大黄素固体分散体及其制备方法与应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0083370A1 (de) * | 1981-07-08 | 1983-07-13 | Key Pharmaceuticals, Inc. | Polymerische diffusionsmatritze 5-((3,4-dimethoxyphenaethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitril enthaltend |
| JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| GB8518301D0 (en) * | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
| DE3612212A1 (de) | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
| US4980378A (en) * | 1988-06-01 | 1990-12-25 | Odontex, Inc. | Biodegradable absorption enhancers |
| DE3839825A1 (de) * | 1988-11-25 | 1990-06-13 | Henning Berlin Gmbh | Feststoffdispersionen enthaltend oxipurinol und/oder seine alkali- oder erdalkalisalze |
| US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
| ATE159426T1 (de) | 1991-04-16 | 1997-11-15 | Nippon Shinyaku Co Ltd | Verfahren zur herstellung einer festen dispersion |
| EP0617612B1 (de) | 1991-12-18 | 1997-09-10 | Warner-Lambert Company | Verfahren für die herstellung einer festen dispersion |
-
1992
- 1992-11-18 EP EP92925333A patent/EP0617612B1/de not_active Expired - Lifetime
- 1992-11-18 CA CA002124821A patent/CA2124821C/en not_active Expired - Fee Related
- 1992-11-18 DE DE69222182T patent/DE69222182T2/de not_active Expired - Fee Related
- 1992-11-18 WO PCT/US1992/009989 patent/WO1993011749A1/en active IP Right Grant
- 1992-11-18 DK DK92925333.4T patent/DK0617612T3/da active
- 1992-11-18 AU AU31426/93A patent/AU671811B2/en not_active Ceased
- 1992-11-18 ES ES92925333T patent/ES2109377T3/es not_active Expired - Lifetime
- 1992-11-18 JP JP51091293A patent/JP3722293B2/ja not_active Expired - Fee Related
- 1992-11-18 AT AT92925333T patent/ATE157864T1/de not_active IP Right Cessation
- 1992-11-18 SG SG1996004974A patent/SG43179A1/en unknown
- 1992-12-16 NZ NZ245483A patent/NZ245483A/en unknown
- 1992-12-16 PT PT101132A patent/PT101132B/pt not_active IP Right Cessation
- 1992-12-17 ZA ZA929789A patent/ZA929789B/xx unknown
- 1992-12-17 MX MX9207390A patent/MX9207390A/es unknown
- 1992-12-18 IL IL104179A patent/IL104179A/xx not_active IP Right Cessation
-
1994
- 1994-03-28 US US08/218,495 patent/US6677362B1/en not_active Expired - Fee Related
-
1997
- 1997-11-26 GR GR970403150T patent/GR3025501T3/el unknown
-
2001
- 2001-06-14 US US09/881,366 patent/US20010044409A1/en not_active Abandoned
-
2003
- 2003-12-03 US US10/726,780 patent/US20040110694A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20040110694A1 (en) | 2004-06-10 |
| IL104179A0 (en) | 1993-05-13 |
| JPH07504162A (ja) | 1995-05-11 |
| EP0617612A1 (de) | 1994-10-05 |
| US6677362B1 (en) | 2004-01-13 |
| EP0617612B1 (de) | 1997-09-10 |
| NZ245483A (en) | 1995-12-21 |
| SG43179A1 (en) | 1997-10-17 |
| AU671811B2 (en) | 1996-09-12 |
| JP3722293B2 (ja) | 2005-11-30 |
| DE69222182T2 (de) | 1998-02-26 |
| CA2124821A1 (en) | 1993-06-24 |
| AU3142693A (en) | 1993-07-19 |
| PT101132B (pt) | 2000-02-29 |
| CA2124821C (en) | 2003-10-07 |
| DK0617612T3 (da) | 1998-04-14 |
| PT101132A (pt) | 1994-03-31 |
| US20010044409A1 (en) | 2001-11-22 |
| DE69222182D1 (de) | 1997-10-16 |
| IL104179A (en) | 1997-11-20 |
| MX9207390A (es) | 1993-06-01 |
| ZA929789B (en) | 1993-06-23 |
| WO1993011749A1 (en) | 1993-06-24 |
| ES2109377T3 (es) | 1998-01-16 |
| GR3025501T3 (en) | 1998-02-27 |
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