ATE180484T1 - Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden - Google Patents
Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptidenInfo
- Publication number
- ATE180484T1 ATE180484T1 AT93908688T AT93908688T ATE180484T1 AT E180484 T1 ATE180484 T1 AT E180484T1 AT 93908688 T AT93908688 T AT 93908688T AT 93908688 T AT93908688 T AT 93908688T AT E180484 T1 ATE180484 T1 AT E180484T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptides
- proteins
- labels
- conjugates
- receptors
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
- 229940127240 opiate Drugs 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 238000003018 immunoassay Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/816—Alkaloids, amphetamines, and barbiturates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86410792A | 1992-04-06 | 1992-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE180484T1 true ATE180484T1 (de) | 1999-06-15 |
Family
ID=25342546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93908688T ATE180484T1 (de) | 1992-04-06 | 1993-03-31 | Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5610283A (de) |
| EP (1) | EP0635019B1 (de) |
| JP (1) | JPH07505634A (de) |
| AT (1) | ATE180484T1 (de) |
| AU (1) | AU3941893A (de) |
| CA (1) | CA2132342A1 (de) |
| DE (1) | DE69325096T2 (de) |
| WO (1) | WO1993020079A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002501923A (ja) | 1998-01-29 | 2002-01-22 | モナシュ ユニバーシティ | 治療用化合物 |
| US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6262265B1 (en) * | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
| EP2080511A3 (de) * | 2000-08-22 | 2009-09-30 | Shire LLC | Aktivmittelzufuhrsysteme und Verfahren zum Schutz und zur Lieferung von Aktivmitteln |
| US8394813B2 (en) * | 2000-11-14 | 2013-03-12 | Shire Llc | Active agent delivery systems and methods for protecting and administering active agents |
| TWI255186B (en) * | 2001-06-05 | 2006-05-21 | Control Delivery Sys Inc | Sustained-release analgesic compounds |
| US7169752B2 (en) * | 2003-09-30 | 2007-01-30 | New River Pharmaceuticals Inc. | Compounds and compositions for prevention of overdose of oxycodone |
| US20060014697A1 (en) * | 2001-08-22 | 2006-01-19 | Travis Mickle | Pharmaceutical compositions for prevention of overdose or abuse |
| JP2005518354A (ja) * | 2001-11-19 | 2005-06-23 | コントロール・デリバリー・システムズ・インコーポレイテッド | コドラッグを含有する医薬組成物 |
| GB0130535D0 (en) * | 2001-12-20 | 2002-02-06 | Randox Lab Ltd | Haptens immunogens antibodies and conjugates to oxycodone and its metabolites |
| US7700561B2 (en) | 2002-02-22 | 2010-04-20 | Shire Llc | Abuse-resistant amphetamine prodrugs |
| US20050130243A1 (en) * | 2003-12-15 | 2005-06-16 | Zheng Yi F. | Assay for entactogens |
| US6991911B2 (en) * | 2003-12-15 | 2006-01-31 | Dade Behring Inc. | Assay for entactogens |
| US7022492B2 (en) * | 2003-12-15 | 2006-04-04 | Dade Behring Inc. | Ecstasy haptens and immunogens |
| US7037669B2 (en) * | 2004-03-22 | 2006-05-02 | Dade Behring Inc. | Assays for amphetamine and methamphetamine using stereospecific reagents |
| US7115383B2 (en) * | 2004-03-22 | 2006-10-03 | Dade Behring Inc. | Assays for amphetamine and methamphetamine |
| CA2585533A1 (en) * | 2004-10-27 | 2006-05-18 | Mallinckrodt Inc. | Method for separation and purification of hydrocodone by preparative chromatography |
| US7238791B1 (en) * | 2005-12-16 | 2007-07-03 | Roche Diagnostics Operations, Inc. | 6-monoacetylmorphine derivatives useful in immunoassay |
| WO2007120648A2 (en) * | 2006-04-10 | 2007-10-25 | Shire Llc | Mono and di-substituted oxycodone compounds and compositions |
| WO2007120864A2 (en) * | 2006-04-14 | 2007-10-25 | Shire Llc | Compositions and methods for enhancing analgesic potency of covalently bound compounds, attenuating its adverse side effects, and preventing their abuse |
| US20080207668A1 (en) * | 2006-10-06 | 2008-08-28 | New River Pharmaceuticals Inc. | Pharmaceutical compositions of hydromorphone for prevention of overdose or abuse |
| ES2713852T3 (es) | 2009-12-01 | 2019-05-24 | Translate Bio Inc | Derivado de esteroides para la administración de ARNm en enfermedades genéticas humanas |
| KR102128248B1 (ko) | 2011-06-08 | 2020-07-01 | 샤이어 휴먼 지네틱 테라피즈 인크. | Mrna 전달을 위한 지질 나노입자 조성물 및 방법 |
| US20150343054A1 (en) * | 2011-12-21 | 2015-12-03 | Kim D. Janda | Heroin Haptens, Immunoconjugates and Related Uses |
| EP3536787A1 (de) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nukleaseresistente polynukleotide und verwendungen davon |
| CN105916860A (zh) * | 2013-03-14 | 2016-08-31 | 美艾利尔圣地亚哥公司 | 6-单乙酰吗啡类似物的合成和使用方法 |
| UA117008C2 (uk) | 2013-03-14 | 2018-06-11 | Шир Хьюман Дженетік Терапіс, Інк. | IN VITRO ТРАНСКРИБОВАНА мРНК ТА КОМПОЗИЦІЯ, ЩО ЇЇ МІСТИТЬ, ДЛЯ ЗАСТОСУВАННЯ В ЛІКУВАННІ МУКОВІСЦИДОЗУ В ССАВЦЯ |
| US9957499B2 (en) | 2013-03-14 | 2018-05-01 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| CN106413811A (zh) | 2013-10-22 | 2017-02-15 | 夏尔人类遗传性治疗公司 | 精氨基琥珀酸合成酶缺乏症的mrna疗法 |
| EA034103B1 (ru) | 2013-10-22 | 2019-12-27 | Транслейт Био, Инк. | СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
| WO2015164773A1 (en) | 2014-04-25 | 2015-10-29 | Shire Human Genetic Therapies, Inc. | Methods for purification of messenger rna |
| CN108884127A (zh) | 2016-01-21 | 2018-11-23 | 斯克利普斯研究院 | 合成的阿片类疫苗 |
| AU2018224326B2 (en) | 2017-02-27 | 2024-01-04 | Translate Bio, Inc. | Novel codon-optimized CFTR mRNA |
| EP3624824B1 (de) | 2017-05-16 | 2024-07-10 | Translate Bio, Inc. | Codonoptimierter mrna, die cftr codiert, zur verwendung in der behandlung von zystischer fibrose |
| WO2019094528A1 (en) | 2017-11-09 | 2019-05-16 | The Scripps Research Institute | An improved heroin vaccine |
| AU2019325702A1 (en) | 2018-08-24 | 2021-02-25 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| WO2020106946A1 (en) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3852157A (en) * | 1971-05-14 | 1974-12-03 | Syva Corp | Compounds for enzyme amplification assay |
| US3884898A (en) * | 1972-08-18 | 1975-05-20 | Syva Co | Normorphine derivatives bonded to proteins |
| SE404553B (sv) * | 1977-03-04 | 1978-10-09 | Pharmacia Diagnostics Ab | Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner |
| SE427505B (sv) * | 1977-03-04 | 1983-04-11 | Pharmacia Diagnostics Ab | Reagens till anvendning vid immunkemiska bestemningsmetoder |
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| US4939264A (en) * | 1986-07-14 | 1990-07-03 | Abbott Laboratories | Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies |
| JP3290988B2 (ja) * | 1991-04-11 | 2002-06-10 | バイオサイト・ダイアグノスティックス・インコーポレイテッド | 多重リガンドを同時検出する新規接合体及び検定法 |
-
1993
- 1993-03-31 AT AT93908688T patent/ATE180484T1/de active
- 1993-03-31 EP EP93908688A patent/EP0635019B1/de not_active Expired - Lifetime
- 1993-03-31 JP JP5517657A patent/JPH07505634A/ja active Pending
- 1993-03-31 WO PCT/US1993/003009 patent/WO1993020079A1/en active IP Right Grant
- 1993-03-31 CA CA002132342A patent/CA2132342A1/en not_active Abandoned
- 1993-03-31 DE DE69325096T patent/DE69325096T2/de not_active Expired - Fee Related
- 1993-03-31 AU AU39418/93A patent/AU3941893A/en not_active Abandoned
-
1995
- 1995-02-15 US US08/389,969 patent/US5610283A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993020079A1 (en) | 1993-10-14 |
| US5610283A (en) | 1997-03-11 |
| CA2132342A1 (en) | 1993-10-14 |
| EP0635019A1 (de) | 1995-01-25 |
| EP0635019B1 (de) | 1999-05-26 |
| DE69325096T2 (de) | 1999-09-30 |
| DE69325096D1 (de) | 1999-07-01 |
| JPH07505634A (ja) | 1995-06-22 |
| EP0635019A4 (de) | 1995-02-01 |
| AU3941893A (en) | 1993-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69325096D1 (de) | Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden | |
| ES2110230T3 (es) | Ensayo de rapamicina. | |
| DE68918867D1 (de) | Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen. | |
| SE8202012L (sv) | Humaninterferon-beslektade peptider, antigener, antikroppar och forfarande for framstellning derav | |
| NO961115D0 (no) | Humane metabotrope glutamatreseptorsubtyper (HMR4, HMR6, HMR7) og relaterte DNA forbindelser | |
| AU1130392A (en) | Synthetic htlv-iii peptides, compositions and uses thereof | |
| DE69317886D1 (de) | Neue propoxyphenderivate sowie deren protein-und polypeptidlabels und-konjugate | |
| DE69328779D1 (de) | Benzodiazepin-derivate sowie deren konjugate mit proteinen und polypeptiden | |
| AU6171894A (en) | Preparation of photoprotein conjugates and methods of use thereof | |
| EP0341158A3 (en) | Vitamin d derivatives : their utilization in therapy and for the quantitative determination of vitamin d metabolites | |
| DE3773077D1 (de) | Immunotoxine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| DE69231495D1 (de) | Neue cocain-derivate und protein- und polypeptid-cocain-derivate, konjugate und markierte verbindungen | |
| DE69611037D1 (de) | Methadonderivate und protein- und polypeptid-methadonkonjugate und markierte verbindungen | |
| FI102383B1 (fi) | Menetelmä ja plasmidi modifioidun PE40-domeenia sisältävän hybridiproteiinin valmistamiseksi | |
| EP1216994A3 (de) | Trizyklische Antidepressiva und Immunoassay | |
| ATE52251T1 (de) | Histamin-derivate, immunogen-konjugate und dadurch induzierte antikoerper. | |
| SE8602523D0 (sv) | 2-alkyl- eller -aralkyltio-1-cykloalken-1-karboxamider och deras sulfoxider, sett for deras framstellning och deras anvendning for syntes av tri- och 4,5-tetrametylen-4-isotiazolin-3-oner | |
| AU3936393A (en) | Haptens, tracers, immunogens and antibodies for acridine-9-carboxylic acids | |
| EP0334076A3 (en) | Monoclonal antibody capable of recognizing an antigen associated with human arteriosclerosis, and process for preparing the same | |
| AU5790390A (en) | A novel tumor associated antigen | |
| KR860008779A (ko) | 항체 형성 화합물의 제조방법 |