ATE183206T1 - Schwermetallsalze von bernsteinsäurehalbester mit hyaluronsäure oder hyaluronsäureester, verfahren zu ihrer herstellung und verbundene pharmazeutische zusammensetzungen - Google Patents
Schwermetallsalze von bernsteinsäurehalbester mit hyaluronsäure oder hyaluronsäureester, verfahren zu ihrer herstellung und verbundene pharmazeutische zusammensetzungenInfo
- Publication number
- ATE183206T1 ATE183206T1 AT96916030T AT96916030T ATE183206T1 AT E183206 T1 ATE183206 T1 AT E183206T1 AT 96916030 T AT96916030 T AT 96916030T AT 96916030 T AT96916030 T AT 96916030T AT E183206 T1 ATE183206 T1 AT E183206T1
- Authority
- AT
- Austria
- Prior art keywords
- hyaluronic acid
- heavy metal
- metal salts
- production
- pharmaceutical compositions
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 4
- 229910001385 heavy metal Inorganic materials 0.000 title abstract 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title abstract 4
- 229920002674 hyaluronan Polymers 0.000 title abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 3
- 239000001384 succinic acid Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000007787 solid Substances 0.000 abstract 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 abstract 1
- 229940014800 succinic anhydride Drugs 0.000 abstract 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 abstract 1
- 125000005497 tetraalkylphosphonium group Chemical group 0.000 abstract 1
- 238000001291 vacuum drying Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95PD000090A IT1281877B1 (it) | 1995-05-10 | 1995-05-10 | Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE183206T1 true ATE183206T1 (de) | 1999-08-15 |
Family
ID=11391041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96916030T ATE183206T1 (de) | 1995-05-10 | 1996-05-08 | Schwermetallsalze von bernsteinsäurehalbester mit hyaluronsäure oder hyaluronsäureester, verfahren zu ihrer herstellung und verbundene pharmazeutische zusammensetzungen |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0827514B1 (de) |
| JP (1) | JP4264671B2 (de) |
| AT (1) | ATE183206T1 (de) |
| AU (1) | AU695512B2 (de) |
| CA (1) | CA2220682C (de) |
| DE (1) | DE69603721T2 (de) |
| ES (1) | ES2137694T3 (de) |
| IT (1) | IT1281877B1 (de) |
| WO (1) | WO1996035720A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0781566B1 (de) * | 1995-12-26 | 2004-07-28 | Toyo Boseki Kabushiki Kaisha | In organischen Lösungsmitteln lösliche Mucopolysaccharide, antibakterielles antithrombogenes Mittel und medizinisches Material |
| IT1291452B1 (it) | 1997-04-14 | 1999-01-11 | Fidia Advanced Biopolymers Srl | Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni |
| IT1294797B1 (it) * | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
| US6872819B1 (en) * | 1998-05-27 | 2005-03-29 | Fidia Advanced Biopolymers S.R.L. | Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells |
| ITPD980149A1 (it) | 1998-06-17 | 1999-12-17 | Fidia Advanced Biopolymers Srl | Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la |
| JP2003089647A (ja) * | 1999-03-10 | 2003-03-28 | Takada Seiyaku Kk | 関節性疾患治療剤 |
| HK1047884A1 (zh) * | 1999-06-18 | 2003-03-14 | Ml Laboratories Plc | 生物活性材料 |
| GB2392913B (en) * | 2002-09-11 | 2007-04-04 | Johnson & Johnson Medical Ltd | Wound dressings comprising complexes of oxidised celluloses with silver |
| DE60313471T2 (de) | 2002-09-11 | 2008-01-03 | Johnson & Johnson Medical Ltd. | Wundverbandmaterial mit anionischen polysaccharid-komplexen mit silber |
| DK200301128A (da) | 2003-08-05 | 2005-02-06 | Thomsen Joern Oddershede | Tilskudspræparat |
| US7993678B2 (en) | 2005-09-26 | 2011-08-09 | Novozymes Biopolymer A/S | Hyaluronic acid derivatives |
| IT1402786B1 (it) * | 2010-11-19 | 2013-09-18 | Fidia Farmaceutici | Composizioni farmaceutiche ad attivita' antibatterica e cicatrizzante |
| CZ2012842A3 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| SMT202200083T1 (it) | 2014-02-27 | 2022-03-21 | Synartro Ab | Coniugati di ialuronano con sostanze farmaceuticamente attive, metodi e composizioni |
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| MA41912A (fr) * | 2015-04-07 | 2018-02-13 | Hyalblue S R L | Esters de glycosaminoglycane, procédés pour leur préparation et leur utilisation dans des formulations à usage ophtalmique |
| CZ306479B6 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| WO2019121488A1 (en) * | 2017-12-21 | 2019-06-27 | Nicox S.A. | Nitric oxide releasing hyaluronic esters |
| JP7066909B1 (ja) * | 2020-12-25 | 2022-05-13 | 参天製薬株式会社 | 高分子化合物、銀塩およびイオン性等張化剤を含有する水性点眼液 |
| IT202100012737A1 (it) | 2021-05-18 | 2022-11-18 | Jointherapeutics S R L | Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate |
| IT202100013787A1 (it) | 2021-05-27 | 2022-11-27 | Farmigea Spa | Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery |
| IT202200004613A1 (it) | 2022-03-10 | 2023-09-10 | Cmed Aesthetics S R L | “procedimento di preparazione di prodotti sterili” |
| WO2024038088A1 (en) | 2022-08-16 | 2024-02-22 | Synartro Ab | Liquid formulations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5436388A (en) * | 1977-08-26 | 1979-03-17 | Sumitomo Electric Ind Ltd | Porous polysaccharide and its preparation |
| DE3273138D1 (en) * | 1981-06-02 | 1986-10-16 | Eupan Corp | Eustatic composition for nonspecifically facilitating and amplifying the generalized homeostatic regulation and maintenance, compensation and repair in living organisms |
| CA1291034C (en) * | 1987-10-19 | 1991-10-22 | Mostafa S. Fahim | Composition for promoting epithelial regeneration |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US4746504A (en) * | 1986-03-14 | 1988-05-24 | Bio-Technology General Corp. | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
-
1995
- 1995-05-10 IT IT95PD000090A patent/IT1281877B1/it active IP Right Grant
-
1996
- 1996-05-08 AT AT96916030T patent/ATE183206T1/de not_active IP Right Cessation
- 1996-05-08 JP JP53376996A patent/JP4264671B2/ja not_active Expired - Fee Related
- 1996-05-08 DE DE69603721T patent/DE69603721T2/de not_active Expired - Lifetime
- 1996-05-08 WO PCT/EP1996/001979 patent/WO1996035720A1/en active IP Right Grant
- 1996-05-08 EP EP96916030A patent/EP0827514B1/de not_active Expired - Lifetime
- 1996-05-08 AU AU58944/96A patent/AU695512B2/en not_active Ceased
- 1996-05-08 ES ES96916030T patent/ES2137694T3/es not_active Expired - Lifetime
- 1996-05-08 CA CA002220682A patent/CA2220682C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU695512B2 (en) | 1998-08-13 |
| CA2220682C (en) | 2006-10-24 |
| ITPD950090A1 (it) | 1996-11-10 |
| ITPD950090A0 (it) | 1995-05-10 |
| WO1996035720A1 (en) | 1996-11-14 |
| DE69603721D1 (de) | 1999-09-16 |
| DE69603721T2 (de) | 2000-01-13 |
| JP4264671B2 (ja) | 2009-05-20 |
| IT1281877B1 (it) | 1998-03-03 |
| CA2220682A1 (en) | 1996-11-14 |
| EP0827514B1 (de) | 1999-08-11 |
| JPH11504668A (ja) | 1999-04-27 |
| ES2137694T3 (es) | 1999-12-16 |
| AU5894496A (en) | 1996-11-29 |
| EP0827514A1 (de) | 1998-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |