ATE192500T1 - Rekombinante viren vektoren zur expression in muskelzellen - Google Patents
Rekombinante viren vektoren zur expression in muskelzellenInfo
- Publication number
- ATE192500T1 ATE192500T1 AT92921684T AT92921684T ATE192500T1 AT E192500 T1 ATE192500 T1 AT E192500T1 AT 92921684 T AT92921684 T AT 92921684T AT 92921684 T AT92921684 T AT 92921684T AT E192500 T1 ATE192500 T1 AT E192500T1
- Authority
- AT
- Austria
- Prior art keywords
- muscle cells
- expression
- vectors
- recombinant virus
- virus vectors
- Prior art date
Links
- 210000000663 muscle cell Anatomy 0.000 title abstract 5
- 239000013598 vector Substances 0.000 title abstract 4
- 241000700605 Viruses Species 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9111947A FR2681786A1 (fr) | 1991-09-27 | 1991-09-27 | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
| PCT/FR1992/000898 WO1993006223A1 (fr) | 1991-09-27 | 1992-09-25 | Vecteurs recombinants viraux pour l'expression dans des cellules musculaires |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE192500T1 true ATE192500T1 (de) | 2000-05-15 |
Family
ID=9417378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92921684T ATE192500T1 (de) | 1991-09-27 | 1992-09-25 | Rekombinante viren vektoren zur expression in muskelzellen |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0559884B2 (de) |
| JP (1) | JP3487597B2 (de) |
| AT (1) | ATE192500T1 (de) |
| AU (1) | AU666142B2 (de) |
| CA (1) | CA2097185C (de) |
| DE (1) | DE69230993T3 (de) |
| DK (1) | DK0559884T4 (de) |
| ES (1) | ES2147553T5 (de) |
| FR (1) | FR2681786A1 (de) |
| GR (1) | GR3034094T3 (de) |
| SG (1) | SG49081A1 (de) |
| WO (1) | WO1993006223A1 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5538722A (en) * | 1989-06-13 | 1996-07-23 | Stanford University | Isolation, growth, differentiation and genetic engineering of human muscle cells |
| WO1994010322A1 (en) * | 1992-10-29 | 1994-05-11 | Board Of Regents, The University Of Texas System | Adenovirus-mediated ldl receptor gene transfer and targeting |
| JPH08506008A (ja) * | 1992-11-18 | 1996-07-02 | アーチ ディベロプメント コーポレイション | 心筋及び血管平滑筋へのアデノウィルス介在遺伝子移入 |
| FR2705361B1 (fr) * | 1993-05-18 | 1995-08-04 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| US6133028A (en) * | 1993-05-28 | 2000-10-17 | Transgene S.A. | Defective adenoviruses and corresponding complementation lines |
| FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| US20020136708A1 (en) | 1993-06-24 | 2002-09-26 | Graham Frank L. | System for production of helper dependent adenovirus vectors based on use of endonucleases |
| US6120764A (en) * | 1993-06-24 | 2000-09-19 | Advec, Inc. | Adenoviruses for control of gene expression |
| US7045347B2 (en) | 1993-06-24 | 2006-05-16 | Advec, Inc. | Helper dependent adenovirus vectors based on integrase family site-specific recombinases |
| US5919676A (en) * | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| WO1995000655A1 (en) * | 1993-06-24 | 1995-01-05 | Mc Master University | Adenovirus vectors for gene therapy |
| US6140087A (en) * | 1993-06-24 | 2000-10-31 | Advec, Inc. | Adenovirus vectors for gene therapy |
| US6730507B1 (en) | 1993-06-24 | 2004-05-04 | Merck & Co., Inc. | Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration |
| US6080569A (en) * | 1993-06-24 | 2000-06-27 | Merck & Co., Inc. | Adenovirus vectors generated from helper viruses and helper-dependent vectors |
| FR2707664B1 (fr) * | 1993-07-13 | 1995-09-29 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| FR2718749B1 (fr) * | 1994-04-18 | 1996-05-31 | Centre Nat Rech Scient | Vecteurs viraux et utilisation en thérapie génique. |
| WO1995002697A1 (fr) * | 1993-07-13 | 1995-01-26 | Rhone-Poulenc Rorer S.A. | Vecteurs adenoviraux defectifs et utilisation en therapie genique |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| CA2188575A1 (en) | 1995-02-28 | 1996-09-06 | H. Kirk Hammond | Gene transfer-mediated angiogenesis therapy |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| US6281010B1 (en) | 1995-06-05 | 2001-08-28 | The Trustees Of The University Of Pennsylvania | Adenovirus gene therapy vehicle and cell line |
| US6974694B2 (en) | 1995-06-07 | 2005-12-13 | Advec, Inc. | Adenoviruses for control of gene expression |
| US6783980B2 (en) | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US5837534A (en) * | 1995-11-14 | 1998-11-17 | The Board Of Regents Of The University Of Texas System | Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells |
| US5866552A (en) * | 1996-09-06 | 1999-02-02 | The Trustees Of The University Of Pennsylvania | Method for expressing a gene in the absence of an immune response |
| US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
| BR9810369A (pt) | 1997-06-30 | 2000-09-05 | Rhone Poulenc Rorer Sa | Processo de transferência de ácido nucleico para o interior de um ou mais músculos estriados, in vivo, composição, ácido mucleico e campo elétrico, e, produto de combinação |
| US6914131B1 (en) | 1998-10-09 | 2005-07-05 | Chiron S.R.L. | Neisserial antigens |
| EP1029052B1 (de) | 1997-11-06 | 2010-08-04 | Novartis Vaccines and Diagnostics S.r.l. | Neisseriale antigene |
| EP2210945B1 (de) | 1998-01-14 | 2013-06-26 | Novartis Vaccines and Diagnostics S.r.l. | Antigene aus Neisseria meningitidis |
| JP2002502608A (ja) | 1998-02-06 | 2002-01-29 | コラテラル・セラピューティックス・インコーポレイテッド | 血管新生促進因子である血管内皮細胞成長因子:vegfの変異体 |
| MX343744B (es) | 1998-05-01 | 2016-11-22 | J Craig Venter Inst Inc | Antigenos de neisseria meningitidis y composiciones que los contienen. |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| EP1953229A3 (de) | 1998-10-15 | 2008-12-24 | Novartis Vaccines and Diagnostics, Inc. | Metastatische Brust- und Dickdarmkrebs-regulierte Gene |
| US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| JP2003524389A (ja) | 1998-12-16 | 2003-08-19 | カイロン コーポレイション | ヒトサイクリン依存的キナーゼ(hPNQALRE) |
| US6673601B1 (en) | 1999-04-15 | 2004-01-06 | Institut Pasteur | Chimeric lyssavirus nucleic acids and polypeptides |
| EP1721982B1 (de) | 1999-04-15 | 2013-04-10 | Boehringer Ingelheim Vetmedica GmbH | Chimäre Nukleinsäuren und Polypeptide aus Iyssavirus |
| BR0010130A (pt) | 1999-04-30 | 2002-06-04 | Chiron Spa | Antìgenos de neisseria conservados |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
| GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
| MXPA02004283A (es) | 1999-10-29 | 2002-10-17 | Chiron Spa | Peptidos antigenicos neisseriales. |
| BRPI0107679B8 (pt) | 2000-01-17 | 2021-05-25 | Chiron Spa | composição compreendendo vesículas de membrana externa do grupo sérico b de neisseria meningitidis e um componente inorgânico e uso da mesma |
| CN100473663C (zh) | 2000-02-28 | 2009-04-01 | 启龙股份公司 | 奈瑟球菌蛋白质的异源表达 |
| US7238672B1 (en) | 2000-04-17 | 2007-07-03 | Institut Pasteur | Chimeric lyssavirus nucleic acids and polypeptides |
| EP1950297A2 (de) | 2000-05-31 | 2008-07-30 | Novartis Vaccines and Diagnostics, Inc. | Zusammensetzungen und Verfahren zur Behandlung neoplastischer Erkrankungen mithilfe von Chemotherapie und Strahlungssensibilisatoren |
| EP1191104A1 (de) * | 2000-09-26 | 2002-03-27 | Introgene B.V. | Genträger und deren Verwendung zur Herstellung von Arzneimitteln und/oder Impfstöffen |
| US7235233B2 (en) | 2000-09-26 | 2007-06-26 | Crucell Holland B.V. | Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts |
| AU2001290273A1 (en) * | 2000-10-06 | 2002-04-22 | Dnavec Research Inc. | Paramyxovirus vector for transferring foreign gene into skeletal muscle |
| EP2189473A3 (de) | 2000-10-27 | 2010-08-11 | Novartis Vaccines and Diagnostics S.r.l. | Nukleinsäure und Proteine von Gruppen A und B Streptokokken |
| GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
| FR2829136B1 (fr) | 2001-08-29 | 2006-11-17 | Aventis Pharma Sa | Derives lipidiques d'aminoglycosides |
| EP1463520B1 (de) | 2001-12-12 | 2008-09-03 | Novartis Vaccines and Diagnostics S.r.l. | Immunisierung gegen chlamydia tracheomatis |
| ES2335657T3 (es) | 2002-04-25 | 2010-03-31 | Crucell Holland B.V. | Medios y metodos para la produccion de vectores de adenovirus. |
| GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
| PT1736541E (pt) | 2004-03-29 | 2013-01-31 | Galpharma Co Ltd | Nova proteína galectina 9 modificada e sua utilização |
| WO2006042017A2 (en) | 2004-10-06 | 2006-04-20 | University Of Rochester | Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway |
| US8999944B2 (en) | 2005-01-20 | 2015-04-07 | University Of Rochester | Thioredoxin interacting protein (TXNIP) as regulator of vascular function |
| US8026354B2 (en) | 2005-11-23 | 2011-09-27 | Institut Pasteur | Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use |
| US20100015168A1 (en) | 2006-06-09 | 2010-01-21 | Novartis Ag | Immunogenic compositions for streptococcus agalactiae |
| US8673859B2 (en) | 2007-03-20 | 2014-03-18 | New York University | GM-CSF cosmeceutical compositions and methods of use thereof |
| US8790664B2 (en) | 2008-09-05 | 2014-07-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Multimodular assembly useful for intracellular delivery |
| WO2010107991A2 (en) | 2009-03-18 | 2010-09-23 | Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Use of ixolaris, a tissue factor inhibitor, for the treatment and prevention of cancer |
| CA3120504A1 (en) | 2009-06-10 | 2010-12-16 | New York University | Immunological targeting of pathological tau proteins |
| WO2012092341A1 (en) | 2010-12-28 | 2012-07-05 | University Of Rochester | Methods of modifying insulin signaling using biliverdin reductase (bvr) and bvr derived peptides |
| EP2753346B1 (de) | 2011-09-07 | 2020-04-22 | Mount Sinai School Of Medicine | Ceramidase und zelldifferenzierung |
| EP2908853B1 (de) | 2012-10-21 | 2018-12-05 | University Of Rochester | Thy1 (cd90) als therapie zur steuerung von fettgewebeakkumulation |
| EP2992112B1 (de) | 2013-04-22 | 2020-06-03 | Icahn School of Medicine at Mount Sinai | Mutationen in pdgfrb und notch3 als ursachen für autosomale dominante infantile myofibromatose |
| EP3371211B1 (de) | 2015-11-04 | 2025-01-01 | Icahn School of Medicine at Mount Sinai | Rho-assoziierte proteinkinasehemmer zur behandlung von tumoren und krebs sowie identifizierung von kandidatenpatienten für solch eine behandlung |
| EP3448881B1 (de) | 2016-04-26 | 2023-06-07 | Icahn School of Medicine at Mount Sinai | Behandlung von hippo-pfad-mutanten tumoren und verfahren zur identifizierung von probanden als kandidaten für die behandlung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL76751A (en) * | 1984-11-01 | 1991-04-15 | American Home Prod | Method and oral vaccines against infectious organisms using live,recombinant adenovirus for the production of antibodies |
| FR2573436B1 (fr) * | 1984-11-20 | 1989-02-17 | Pasteur Institut | Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins |
| DE3751664T2 (de) * | 1986-08-01 | 1996-06-05 | Commw Scient Ind Res Org | Rekombinanter impfstoff |
| CA2049287C (en) * | 1989-03-21 | 2005-03-29 | Philip L. Felgner | Expression of exogenous polynucleotide sequences in a vertebrate |
| JPH05500748A (ja) * | 1989-05-01 | 1993-02-18 | ザ ユニバーシティ オブ ノートル ダム デュ ラック | 真核細胞系でのヒトプラスミノーゲンの発現方法および物質 |
| GB9001766D0 (en) * | 1990-01-25 | 1990-03-28 | Univ Court Of The University O | Vaccines |
-
1991
- 1991-09-27 FR FR9111947A patent/FR2681786A1/fr active Granted
-
1992
- 1992-09-25 CA CA002097185A patent/CA2097185C/fr not_active Expired - Lifetime
- 1992-09-25 ES ES92921684T patent/ES2147553T5/es not_active Expired - Lifetime
- 1992-09-25 AT AT92921684T patent/ATE192500T1/de active
- 1992-09-25 DK DK92921684T patent/DK0559884T4/da active
- 1992-09-25 JP JP50585393A patent/JP3487597B2/ja not_active Expired - Lifetime
- 1992-09-25 EP EP92921684A patent/EP0559884B2/de not_active Expired - Lifetime
- 1992-09-25 AU AU27902/92A patent/AU666142B2/en not_active Expired
- 1992-09-25 SG SG1996005855A patent/SG49081A1/en unknown
- 1992-09-25 WO PCT/FR1992/000898 patent/WO1993006223A1/fr active IP Right Grant
- 1992-09-25 DE DE69230993T patent/DE69230993T3/de not_active Expired - Lifetime
-
2000
- 2000-08-02 GR GR20000401791T patent/GR3034094T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0559884A1 (de) | 1993-09-15 |
| DE69230993T2 (de) | 2000-11-30 |
| DE69230993D1 (de) | 2000-06-08 |
| EP0559884B1 (de) | 2000-05-03 |
| ES2147553T5 (es) | 2004-11-16 |
| CA2097185C (fr) | 2007-07-24 |
| CA2097185A1 (fr) | 1993-03-28 |
| DK0559884T4 (da) | 2004-08-02 |
| SG49081A1 (en) | 1998-05-18 |
| DE69230993T3 (de) | 2004-12-16 |
| FR2681786B1 (de) | 1995-05-12 |
| JP3487597B2 (ja) | 2004-01-19 |
| GR3034094T3 (en) | 2000-11-30 |
| ES2147553T3 (es) | 2000-09-16 |
| WO1993006223A1 (fr) | 1993-04-01 |
| EP0559884B2 (de) | 2004-04-07 |
| FR2681786A1 (fr) | 1993-04-02 |
| AU666142B2 (en) | 1996-02-01 |
| JPH06502771A (ja) | 1994-03-31 |
| AU2790292A (en) | 1993-04-27 |
| DK0559884T3 (da) | 2000-10-02 |
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