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ATE120732T1 - Pyrrolidin- und thiazolidinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. - Google Patents

Pyrrolidin- und thiazolidinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Info

Publication number
ATE120732T1
ATE120732T1 AT92915456T AT92915456T ATE120732T1 AT E120732 T1 ATE120732 T1 AT E120732T1 AT 92915456 T AT92915456 T AT 92915456T AT 92915456 T AT92915456 T AT 92915456T AT E120732 T1 ATE120732 T1 AT E120732T1
Authority
AT
Austria
Prior art keywords
pyrrolidine
production
products containing
containing same
medicinal products
Prior art date
Application number
AT92915456T
Other languages
English (en)
Inventor
Marc Capet
Claude Cotrel
Claude Guyon
Michel Joannic
Franco Manfre
Gerard Roussel
Marie-Christine Dubroeucq
Michel Cheve
Gilles Dutruc-Rosset
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE120732T1 publication Critical patent/ATE120732T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT92915456T 1991-07-10 1992-07-03 Pyrrolidin- und thiazolidinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. ATE120732T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108675A FR2678938B1 (fr) 1991-07-10 1991-07-10 Derives de pyrrolidine, leur preparation et les medicaments les contenant.

Publications (1)

Publication Number Publication Date
ATE120732T1 true ATE120732T1 (de) 1995-04-15

Family

ID=9414933

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92915456T ATE120732T1 (de) 1991-07-10 1992-07-03 Pyrrolidin- und thiazolidinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.

Country Status (23)

Country Link
US (1) US5610144A (de)
EP (2) EP0527069A1 (de)
JP (1) JP3034043B2 (de)
KR (1) KR100234927B1 (de)
AT (1) ATE120732T1 (de)
AU (1) AU662345B2 (de)
BR (1) BR1100717A (de)
CA (1) CA2102697C (de)
CZ (1) CZ283602B6 (de)
DE (1) DE69201956T2 (de)
DK (1) DK0593639T3 (de)
ES (1) ES2071510T3 (de)
FI (1) FI105190B (de)
FR (1) FR2678938B1 (de)
HU (1) HU223470B1 (de)
IE (1) IE66331B1 (de)
NO (1) NO180166C (de)
NZ (1) NZ243514A (de)
PL (5) PL171054B1 (de)
RU (1) RU2118316C1 (de)
SK (1) SK1694A3 (de)
WO (1) WO1993001167A1 (de)
ZA (1) ZA925128B (de)

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FR2695641B1 (fr) * 1992-09-11 1994-11-25 Rhone Poulenc Rorer Sa (Amino-3 phényl)-1 éthanesulfonate d'hydroquinine optiquement actif, sa préparation et son utilisation.
FR2700168B1 (fr) * 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
FR2700165B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2700166B1 (fr) * 1993-01-07 1995-02-17 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2700167B1 (fr) * 1993-01-07 1995-02-03 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine et thiazolidine, leur préparation et les médicaments les contenant.
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
FR2721314B1 (fr) * 1994-06-20 1996-07-19 Rhone Poulenc Rorer Sa Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
FR2721608B1 (fr) * 1994-06-22 1996-07-19 Rhone Poulenc Rorer Sa Dérivés de thiazolidine, leur préparation et les médicaments les contenant.
FR2734724B1 (fr) * 1995-06-01 1997-07-04 Rhone Poulenc Rorer Sa Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'alcoolisme
KR100241643B1 (ko) * 1995-06-06 2000-03-02 디. 제이. 우드 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체
JP3068200B2 (ja) 1995-06-06 2000-07-24 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ阻害剤としての置換ｎ−（インドール−２−カルボニル−）アミドおよび誘導体
FR2744361B1 (fr) * 1996-02-07 1998-02-27 Rhone Poulenc Rorer Sa Application de derives de pyrrolidine a la preparation de medicaments destines au traitement de l'abus de drogues ou de substances donnant lieu a des pharmacomanies ou a un usage excessif
TW442449B (en) 1996-07-04 2001-06-23 Hoechst Ag Process for preparing 1,2-dichloroethane by direct chlorination
IT1300055B1 (it) * 1998-04-17 2000-04-05 Boehringer Ingelheim Italia Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici
YU26700A (sh) * 1999-05-24 2002-06-19 Pfizer Products Inc. Postupak za cis-1-(2-(4-(6-metoksi-2-fenil-1,2,3,4- tetrahidronaftalen-1-il)fenoksi)etil)pirolidin
US6638950B2 (en) * 2000-06-21 2003-10-28 Bristol-Myers Squibb Pharma Company Piperidine amides as modulators of chemokine receptor activity
US6277877B1 (en) * 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
AU2002224797B2 (en) 2000-10-30 2006-10-26 Janssen Pharmaceutica N.V. Tripeptidyl peptidase inhibitors
US7105556B2 (en) 2001-05-30 2006-09-12 Bristol-Myers Squibb Company Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
US7238724B2 (en) 2002-09-19 2007-07-03 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
US7262207B2 (en) 2002-09-19 2007-08-28 Abbott Laboratories Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
PT1560811E (pt) * 2002-09-19 2007-11-14 Abbott Lab Composições farmacêuticas como inibidores de dipeptidilpeptidase-iv ( dpp-iv)
US6846836B2 (en) 2003-04-18 2005-01-25 Bristol-Myers Squibb Company N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase
US7230002B2 (en) 2004-02-03 2007-06-12 Glenmark Pharmaceuticals Ltd. Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof
JP2007522247A (ja) * 2004-02-11 2007-08-09 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション 細胞増殖の阻害を示すアナログ、それを作製する方法およびその使用
WO2007086584A1 (ja) * 2006-01-30 2007-08-02 Meiji Seika Kaisha, Ltd. 新規ＦａｂＫおよびＦａｂＩ／Ｋ阻害剤
JP2009544621A (ja) * 2006-07-20 2009-12-17 アボット・ラボラトリーズ （２ｓ，５ｒ）−５−エチニル−１−｛ｎ−（４−メチル−１−（４−カルボキシ−ピリジン−２−イル）ピペリジン−４−イル）グリシル｝ピロリジン−２−カルボニトリルの合成
US8247438B2 (en) 2008-02-27 2012-08-21 Neuropill, Inc. Methods for treating schizophrenia
CN101407502B (zh) * 2008-11-21 2010-12-22 南京大学 一类n-(叔丁氧基羰基)噻唑烷酸类化合物及其制法和用途
DE102009004204A1 (de) * 2009-01-09 2010-07-15 Christian-Albrechts-Universität Zu Kiel Verfahren zur verbesserten Bioaktivierung von Arzneistoffen
HUE038064T2 (hu) * 2009-12-18 2018-10-29 Ogeda Sa Pirrolidin karboxilsav származékok, mint G-protein kapcsolat receptor 43 (GPR43) agonistái, gyógyszerészeti készítmény és felhasználási eljárások metabolikus rendellenességek kezelésében
WO2012036962A2 (en) 2010-09-13 2012-03-22 Amylin Pharmaceuticals, Inc. C-terminal amidation of polypeptides
JP6854126B2 (ja) 2013-11-27 2021-04-07 エピックス セラピューティクス 炎症性疾患の治療に使用するための化合物、医薬組成物、および方法
KR102630294B1 (ko) 2015-01-24 2024-01-26 아카데미아 시니카 암 마커 및 이를 사용하는 방법
JP2023529885A (ja) * 2020-06-10 2023-07-12 エピックス セラピューティクス （２ｓ，５ｒ）－５－（２－クロロフェニル）－１－（２’－メトキシ－［１，１’－ビフェニル］－４－カルボニル）ピロリジン－２－カルボン酸の合成

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CH362072A (de) * 1957-03-19 1962-05-31 Ciba Geigy Verfahren zur Herstellung neuer Acylpiperidine
US4499102A (en) * 1979-12-13 1985-02-12 Santen Pharmaceutical Co., Ltd. Thiazolidine and pyrrolidine compounds and pharmaceutical compositions containing them
DE3272505D1 (en) * 1981-03-09 1986-09-18 Merck & Co Inc Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives
DE3332633A1 (de) * 1983-09-09 1985-04-04 Luitpold-Werk Chemisch-pharmazeutische Fabrik GmbH & Co, 8000 München Substituierte carbonsaeurederivate, verfahren zu ihrer herstellung, und arzneimittel
AU629376B2 (en) * 1989-08-04 1992-10-01 Mitsubishi Chemical Corporation 1-phenylalkyl-3-phenylurea derivatives
US5258405A (en) * 1990-03-12 1993-11-02 Yamanouchi Pharmaceutical Co., Ltd. Urea derivatives and salts thereof in method for inhibiting the ACAT enzyme

Also Published As

Publication number Publication date
PL171333B1 (pl) 1997-04-30
PL171095B1 (pl) 1997-03-28
JPH06509331A (ja) 1994-10-20
US5610144A (en) 1997-03-11
EP0527069A1 (de) 1993-02-10
IE66331B1 (en) 1995-12-27
SK1694A3 (en) 1994-12-07
HUT70403A (en) 1995-10-30
EP0593639B1 (de) 1995-04-05
DK0593639T3 (da) 1995-07-03
RU2118316C1 (ru) 1998-08-27
WO1993001167A1 (fr) 1993-01-21
DE69201956T2 (de) 1995-11-30
NO180166B (no) 1996-11-18
AU2327592A (en) 1993-02-11
BR1100717A (pt) 2000-03-14
DE69201956D1 (de) 1995-05-11
EP0593639A1 (de) 1994-04-27
ZA925128B (en) 1993-04-28
PL171054B1 (pl) 1997-02-28
KR100234927B1 (ko) 2000-02-01
FR2678938A1 (fr) 1993-01-15
NO934300L (no) 1993-11-26
NO934300D0 (no) 1993-11-26
AU662345B2 (en) 1995-08-31
PL171094B1 (pl) 1997-03-28
FI940072L (fi) 1994-01-07
PL171112B1 (pl) 1997-03-28
HU223470B1 (hu) 2004-07-28
NO180166C (no) 1997-02-26
ES2071510T3 (es) 1995-06-16
FR2678938B1 (fr) 1993-10-08
HU9400061D0 (en) 1994-05-30
JP3034043B2 (ja) 2000-04-17
CA2102697C (fr) 2003-09-30
CA2102697A1 (fr) 1993-01-11
NZ243514A (en) 1995-03-28
CZ283602B6 (cs) 1998-05-13
CZ4994A3 (en) 1994-04-13
IE922244A1 (en) 1993-01-13
FI940072A0 (fi) 1994-01-07
FI105190B (fi) 2000-06-30

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