ATE243705T1 - Nukleosid analogen - Google Patents
Nukleosid analogenInfo
- Publication number
- ATE243705T1 ATE243705T1 AT97902465T AT97902465T ATE243705T1 AT E243705 T1 ATE243705 T1 AT E243705T1 AT 97902465 T AT97902465 T AT 97902465T AT 97902465 T AT97902465 T AT 97902465T AT E243705 T1 ATE243705 T1 AT E243705T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleoside analogue
- nucleoside analogues
- moieties
- oligonucleotides
- rna
- Prior art date
Links
- 229940127073 nucleoside analogue Drugs 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9602025.0A GB9602025D0 (en) | 1996-02-01 | 1996-02-01 | Nucleoside analogues |
| PCT/GB1997/000312 WO1997028177A1 (en) | 1996-02-01 | 1997-02-03 | Nucleoside analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE243705T1 true ATE243705T1 (de) | 2003-07-15 |
Family
ID=10787934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97902465T ATE243705T1 (de) | 1996-02-01 | 1997-02-03 | Nukleosid analogen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6313286B1 (de) |
| EP (1) | EP0880539B1 (de) |
| JP (1) | JP2001501581A (de) |
| KR (1) | KR19990082229A (de) |
| AT (1) | ATE243705T1 (de) |
| AU (1) | AU712867B2 (de) |
| CA (1) | CA2243637A1 (de) |
| DE (1) | DE69723057T2 (de) |
| DK (1) | DK0880539T3 (de) |
| GB (1) | GB9602025D0 (de) |
| WO (1) | WO1997028177A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6600028B1 (en) * | 1997-04-02 | 2003-07-29 | Amersham Pharmacia Biotech Uk Limited | Tricyclic base analogues |
| GB9716231D0 (en) | 1997-07-31 | 1997-10-08 | Amersham Int Ltd | Base analogues |
| US5998604A (en) * | 1997-09-15 | 1999-12-07 | The Perkin-Elmer Corporation | Polynucleotide purification method |
| US6518017B1 (en) | 1997-10-02 | 2003-02-11 | Oasis Biosciences Incorporated | Combinatorial antisense library |
| US20030165888A1 (en) | 2001-07-18 | 2003-09-04 | Brown Bob D. | Oligonucleotide probes and primers comprising universal bases for diagnostic purposes |
| PT1058686E (pt) | 1998-02-25 | 2007-01-31 | Raymond F Schinazi | 2'-fluoronucleósidos |
| GB0016258D0 (en) * | 2000-07-03 | 2000-08-23 | Amersham Pharm Biotech Uk Ltd | Base analogues |
| ES2267803T3 (es) * | 2000-08-11 | 2007-03-16 | University Of Utah Research Foundation | Sondas de oligonucleotidos marcados individuales. |
| US7256019B2 (en) | 2001-08-29 | 2007-08-14 | Ge Healthcare Bio-Sciences Corp. | Terminal phosphate blocked nucleoside polyphosphates |
| US7466307B2 (en) * | 2002-04-11 | 2008-12-16 | Synaptics Incorporated | Closed-loop sensor on a solid-state object position detector |
| US20040014101A1 (en) * | 2002-05-03 | 2004-01-22 | Pel-Freez Clinical Systems, Inc. | Separating and/or identifying polymorphic nucleic acids using universal bases |
| US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
| CN103898207B (zh) * | 2003-08-01 | 2016-09-14 | 戴诺生物技术有限公司 | 自杂交多重靶核酸探针及其使用方法 |
| EP1685149A4 (de) * | 2003-10-22 | 2007-03-28 | Pel Freez Clinical Systems Inc | Primer, verfahren und kits zum nachweis von allelen des killer-cell immunoglobulin-like rezeptors |
| CN103890163B (zh) | 2011-06-19 | 2016-09-14 | 阿博根公司 | 用于样品采集的装置、溶液和方法 |
| US10337049B2 (en) | 2013-06-17 | 2019-07-02 | The Trustees Of Columbia University In The City Of New York | Universal methylation profiling methods |
| CN105408342A (zh) * | 2013-06-17 | 2016-03-16 | 纽约哥伦比亚大学理事会 | 通用甲基化分析方法 |
| JP2017510284A (ja) * | 2014-04-10 | 2017-04-13 | ディーエヌエー ジェノテック インク | 過ヨウ素酸塩を用いる微生物溶解のための方法およびシステム |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0235301B1 (de) * | 1985-09-09 | 1992-07-22 | Teijin Limited | Pyridopyrimidin-nukleotid-abkömmlinge |
| CA2174942A1 (en) | 1993-12-01 | 1995-06-08 | Clifford Smith | Nucleoside analogue method |
| DE4343126A1 (de) * | 1993-12-17 | 1995-06-22 | Hoechst Ag | Festphasensynthese von Oligoribonucleotiden |
-
1996
- 1996-02-01 GB GBGB9602025.0A patent/GB9602025D0/en active Pending
-
1997
- 1997-02-03 AU AU16106/97A patent/AU712867B2/en not_active Ceased
- 1997-02-03 CA CA002243637A patent/CA2243637A1/en not_active Abandoned
- 1997-02-03 KR KR1019980705957A patent/KR19990082229A/ko not_active Withdrawn
- 1997-02-03 EP EP97902465A patent/EP0880539B1/de not_active Expired - Lifetime
- 1997-02-03 US US09/117,494 patent/US6313286B1/en not_active Expired - Fee Related
- 1997-02-03 DE DE69723057T patent/DE69723057T2/de not_active Expired - Fee Related
- 1997-02-03 JP JP09527438A patent/JP2001501581A/ja active Pending
- 1997-02-03 DK DK97902465T patent/DK0880539T3/da active
- 1997-02-03 AT AT97902465T patent/ATE243705T1/de not_active IP Right Cessation
- 1997-02-03 WO PCT/GB1997/000312 patent/WO1997028177A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU1610697A (en) | 1997-08-22 |
| EP0880539B1 (de) | 2003-06-25 |
| DE69723057D1 (de) | 2003-07-31 |
| DK0880539T3 (da) | 2003-09-29 |
| DE69723057T2 (de) | 2004-04-29 |
| AU712867B2 (en) | 1999-11-18 |
| KR19990082229A (ko) | 1999-11-25 |
| WO1997028177A1 (en) | 1997-08-07 |
| CA2243637A1 (en) | 1997-08-07 |
| GB9602025D0 (en) | 1996-04-03 |
| EP0880539A1 (de) | 1998-12-02 |
| US6313286B1 (en) | 2001-11-06 |
| JP2001501581A (ja) | 2001-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0880539 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |