ATE253639T1 - Verfahren zur herstellung von peptiden - Google Patents
Verfahren zur herstellung von peptidenInfo
- Publication number
- ATE253639T1 ATE253639T1 AT92307577T AT92307577T ATE253639T1 AT E253639 T1 ATE253639 T1 AT E253639T1 AT 92307577 T AT92307577 T AT 92307577T AT 92307577 T AT92307577 T AT 92307577T AT E253639 T1 ATE253639 T1 AT E253639T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide
- target peptide
- fusion protein
- terminal
- target
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 17
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 5
- 102000037865 fusion proteins Human genes 0.000 abstract 5
- 210000003000 inclusion body Anatomy 0.000 abstract 3
- 230000001681 protective effect Effects 0.000 abstract 3
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 210000004748 cultured cell Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000265 homogenisation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
- C12N9/2471—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Cardiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23076991 | 1991-08-19 | ||
| JP22352092A JP3531947B2 (ja) | 1991-08-19 | 1992-07-31 | ペプチドの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253639T1 true ATE253639T1 (de) | 2003-11-15 |
Family
ID=26525519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92307577T ATE253639T1 (de) | 1991-08-19 | 1992-08-12 | Verfahren zur herstellung von peptiden |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0528686B8 (de) |
| AT (1) | ATE253639T1 (de) |
| CA (1) | CA2076320C (de) |
| DE (1) | DE69233245T2 (de) |
| ES (1) | ES2206443T3 (de) |
| HU (1) | HU216335B (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037145A (en) | 1994-09-07 | 2000-03-14 | Suntory Limited | Process for production of protein |
| AU700605B2 (en) * | 1994-12-07 | 1999-01-07 | Bionebraska, Inc. | Production of peptides using recombinant fusion protein constructs |
| AU4415796A (en) * | 1994-12-07 | 1996-06-26 | Bionebraska, Inc. | Production of c-terminal amidated peptides from recombinant protein constructs |
| CN1193998A (zh) | 1995-04-11 | 1998-09-23 | 麦克公司 | 以二肽基础的化合物生产的生物方法 |
| IL118473A0 (en) * | 1995-06-02 | 1996-09-12 | Suntory Ltd | Staphylococcus aureus V8 protease genes coding therefor and a method for the production thereof |
| DE19535445A1 (de) * | 1995-09-23 | 1997-03-27 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von natriuretischen Peptiden über Streptavidin-Fusionsproteine |
| AU7566396A (en) * | 1995-11-16 | 1997-06-05 | Boehringer Mannheim Gmbh | Process for the preparation of peptides by way of streptavidin fusion proteins |
| CA2334160C (en) * | 1998-07-10 | 2016-09-27 | N. Stephen Pollitt | Method for producing a peptide with a pi above 8 or below 5 |
| US20020090646A1 (en) * | 2000-05-03 | 2002-07-11 | Amgen Inc. | Calcitonin-related molecules |
| IL142118A0 (en) * | 2001-03-20 | 2002-03-10 | Prochon Biotech Ltd | Method and composition for treatment of skeletal dysplasias |
| DE60331584D1 (de) | 2002-11-26 | 2010-04-15 | Biocon Ltd | Modifizierte natriuretic verbindungen, konjugate und ihre verwendungen |
| JP4663524B2 (ja) | 2003-09-30 | 2011-04-06 | 第一三共株式会社 | ＯｍｐＴプロテアーゼ変異体を用いたポリペプチドの切断方法 |
| JP2024520699A (ja) | 2021-06-02 | 2024-05-24 | トパス セラピューティクス ゲーエムベーハー | Ｎ末端リンカーを含むペプチドを含むナノ粒子 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK175535B1 (da) * | 1987-03-04 | 2004-11-29 | Daiichi Suntory Pharma Co Ltd | Fremgangsmåde til fremstilling af et fysiologisk aktivt cysteinholdigt peptid |
-
1992
- 1992-08-12 AT AT92307577T patent/ATE253639T1/de not_active IP Right Cessation
- 1992-08-18 CA CA002076320A patent/CA2076320C/en not_active Expired - Fee Related
- 1992-08-19 EP EP92307577A patent/EP0528686B8/de not_active Expired - Lifetime
- 1992-08-19 ES ES92307577T patent/ES2206443T3/es not_active Expired - Lifetime
- 1992-08-19 DE DE69233245T patent/DE69233245T2/de not_active Expired - Fee Related
- 1992-08-19 HU HU9202688A patent/HU216335B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69233245T2 (de) | 2004-04-22 |
| CA2076320A1 (en) | 1993-02-20 |
| EP0528686B8 (de) | 2004-01-14 |
| EP0528686A2 (de) | 1993-02-24 |
| CA2076320C (en) | 2003-10-07 |
| AU656791B2 (en) | 1995-02-16 |
| EP0528686B1 (de) | 2003-11-05 |
| DE69233245D1 (de) | 2003-12-11 |
| HU216335B (hu) | 1999-06-28 |
| AU2107892A (en) | 1993-03-11 |
| ES2206443T3 (es) | 2004-05-16 |
| EP0528686A3 (de) | 1994-04-06 |
| HUT62335A (en) | 1993-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0528686 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |