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ATE254930T1 - Hapten-träger-konjugate zur anwendung in der drogen-missbrauchs-therapie - Google Patents

Hapten-träger-konjugate zur anwendung in der drogen-missbrauchs-therapie

Info

Publication number
ATE254930T1
ATE254930T1 AT96910595T AT96910595T ATE254930T1 AT E254930 T1 ATE254930 T1 AT E254930T1 AT 96910595 T AT96910595 T AT 96910595T AT 96910595 T AT96910595 T AT 96910595T AT E254930 T1 ATE254930 T1 AT E254930T1
Authority
AT
Austria
Prior art keywords
hapten
carrier conjugates
disclosed
drug abuse
conjugates
Prior art date
Application number
AT96910595T
Other languages
English (en)
Inventor
Philip A Swain
Victoria C Schad
Julia L Greenstein
Mark A Exley
Barbara S Fox
Stephen P Powers
Malcolm L Gefter
Thomas J Briner
Original Assignee
Xenova Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/563,673 external-priority patent/US5760184A/en
Application filed by Xenova Res Ltd filed Critical Xenova Res Ltd
Application granted granted Critical
Publication of ATE254930T1 publication Critical patent/ATE254930T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96910595T 1995-03-31 1996-03-27 Hapten-träger-konjugate zur anwendung in der drogen-missbrauchs-therapie ATE254930T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41497195A 1995-03-31 1995-03-31
US08/563,673 US5760184A (en) 1995-03-31 1995-11-28 Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
PCT/US1996/004189 WO1996030049A2 (en) 1995-03-31 1996-03-27 Hapten-carrier conjugates for use in drug-abuse therapy

Publications (1)

Publication Number Publication Date
ATE254930T1 true ATE254930T1 (de) 2003-12-15

Family

ID=27022809

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03008324T ATE362380T1 (de) 1995-03-31 1996-03-27 Hapten-träger-konjugate zur anwendung in der drogen-missbrauchs-therapie
AT96910595T ATE254930T1 (de) 1995-03-31 1996-03-27 Hapten-träger-konjugate zur anwendung in der drogen-missbrauchs-therapie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03008324T ATE362380T1 (de) 1995-03-31 1996-03-27 Hapten-träger-konjugate zur anwendung in der drogen-missbrauchs-therapie

Country Status (10)

Country Link
US (1) US6054127A (de)
EP (1) EP0814843B1 (de)
AT (2) ATE362380T1 (de)
AU (1) AU5374996A (de)
CA (1) CA2216658C (de)
DE (2) DE69630877T2 (de)
DK (2) DK1329226T3 (de)
ES (2) ES2210356T3 (de)
PT (1) PT814843E (de)
WO (1) WO1996030049A2 (de)

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US20020032316A1 (en) * 1995-03-31 2002-03-14 Cantab Pharmaceuticals Research Limited Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US5840307A (en) * 1995-03-31 1998-11-24 Immulogic Pharmacuetical Corp. Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US5817770A (en) 1997-03-21 1998-10-06 Drug Abuse Sciences, Inc. Cocaethylene immunogens and antibodies
SE9801923D0 (sv) * 1998-05-29 1998-05-29 Independent Pharmaceutical Ab Nicotine vaccine
US6232082B1 (en) 1998-12-01 2001-05-15 Nabi Hapten-carrier conjugates for treating and preventing nicotine addiction
ATE326222T1 (de) 2000-03-15 2006-06-15 Wolfgang Sadee Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch
AU2002226055A1 (en) * 2000-12-07 2002-06-18 The Scripps Research Institute Cocaine haptens
EP1523334A2 (de) * 2002-07-18 2005-04-20 Cytos Biotechnology AG Hapten-träger-konjugate und ihre verwendung
US7220842B2 (en) * 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine
MXPA04006617A (es) 2004-07-07 2006-01-12 Inst Nac De Psiquiatria Ramon Proceso para la preparacion y uso de una vacuna bivalente contra la adiccion a la morfina-heroina.
US20060024768A1 (en) * 2004-07-29 2006-02-02 Saladax Biomedical, Inc. Taxol immunoassay
EP1854478A1 (de) * 2006-05-12 2007-11-14 Cytos Biotechnology AG Formulierung eines Nikotine-Träger Impfstoffs
US8883817B2 (en) * 2007-10-18 2014-11-11 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
FR2952935B1 (fr) * 2009-11-20 2011-12-02 Sanofi Aventis Procede de preparation du n-biotinyl-6-aminocaproate de n succinimidyle
US20130189754A1 (en) 2011-09-12 2013-07-25 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
US9347065B2 (en) 2012-03-29 2016-05-24 International Aids Vaccine Initiative Methods to improve vector expression and genetic stability
CN108409749B (zh) * 2018-01-30 2019-09-06 中国农业科学院蜜蜂研究所 钩吻素己半抗原和全抗原及其制备方法与应用
WO2021242823A1 (en) * 2020-05-27 2021-12-02 Behnam Babak Compositions and Methods for Treating Cocaine, Nicotine, and Methamphetamine Dependence

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US3888886A (en) * 1972-06-08 1975-06-10 Mobil Oil Corp Oxidation of alkanes to maleic anhydride using promoted vanadium-phosphorus catalyst
US4045420A (en) * 1973-05-29 1977-08-30 Syva Company Non-oxo-carbonyl containing benzoyl ecgonine and cocaine compounds polypeptide and derivatives thereof
US4197237A (en) * 1973-06-01 1980-04-08 Syva Company Antibodies to nitrogen derivatives of benzoyl ecgonine antigenic conjugates thereof
US4207307A (en) * 1977-01-21 1980-06-10 Research Corporation Simultaneous immunoassay of multiple antigens and assay for cocaine metabolites
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JPH04182499A (ja) * 1990-11-14 1992-06-30 Matsushita Electric Ind Co Ltd エクゴニン・タンパク質コンジュゲート及びその誘導体
US5233042A (en) * 1991-12-16 1993-08-03 Biosite Diagnostics, Inc. Cocaine derivatives
US5283066A (en) * 1992-02-19 1994-02-01 Development Center For Biotechnology Method of stimulating an immune response by using a hapten
US5302715A (en) * 1992-04-06 1994-04-12 Biosite Diagnostics, Inc. Benzodiazepine derivatives
AU4377793A (en) * 1992-05-20 1993-12-13 Johns Hopkins University, The Alternative receptor therapy
EP0613899B1 (de) * 1993-03-04 2003-01-15 Matsushita Electric Industrial Co., Ltd. Kokainderivat,Proteinkonjugat,davon,einen monoklonalen Antikörper produzierende Hybridom-Zellinie, Verfahren zur Herstellung der Hybridom-Zellinie und des monoklonalen Antikörpers
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Also Published As

Publication number Publication date
DE69637089D1 (de) 2007-06-28
DK0814843T3 (da) 2004-03-29
EP0814843A2 (de) 1998-01-07
ATE362380T1 (de) 2007-06-15
ES2287379T3 (es) 2007-12-16
DE69630877D1 (de) 2004-01-08
EP0814843B1 (de) 2003-11-26
AU5374996A (en) 1996-10-16
US6054127A (en) 2000-04-25
CA2216658C (en) 2008-05-13
DE69637089T2 (de) 2008-01-17
CA2216658A1 (en) 1996-10-03
DK1329226T3 (da) 2007-09-24
ES2210356T3 (es) 2004-07-01
PT814843E (pt) 2004-04-30
WO1996030049A3 (en) 1997-03-06
DE69630877T2 (de) 2004-11-11
WO1996030049A2 (en) 1996-10-03

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