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ATE279200T1 - Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen - Google Patents

Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen

Info

Publication number
ATE279200T1
ATE279200T1 AT99965069T AT99965069T ATE279200T1 AT E279200 T1 ATE279200 T1 AT E279200T1 AT 99965069 T AT99965069 T AT 99965069T AT 99965069 T AT99965069 T AT 99965069T AT E279200 T1 ATE279200 T1 AT E279200T1
Authority
AT
Austria
Prior art keywords
ethanolates
azithromycin
pharmaceutical compositions
production process
pharmaceutical
Prior art date
Application number
AT99965069T
Other languages
English (en)
Inventor
Claude Singer
Judith Aronhime
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22332273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE279200(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of ATE279200T1 publication Critical patent/ATE279200T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT99965069T 1998-11-30 1999-11-30 Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen ATE279200T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11029898P 1998-11-30 1998-11-30
PCT/US1999/028368 WO2000032203A1 (en) 1998-11-30 1999-11-30 Ethanolate of azithromycin, process for manufacture, and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
ATE279200T1 true ATE279200T1 (de) 2004-10-15

Family

ID=22332273

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99965069T ATE279200T1 (de) 1998-11-30 1999-11-30 Ethanolate des azithromycin, herstllungsverfahren und deren pharmazeutische zusammenstellungen

Country Status (26)

Country Link
US (1) US6365574B2 (de)
EP (2) EP1484062A1 (de)
JP (1) JP2002531409A (de)
KR (1) KR100603226B1 (de)
CN (2) CN100339384C (de)
AP (1) AP1709A (de)
AT (1) ATE279200T1 (de)
AU (1) AU768219B2 (de)
BG (1) BG105547A (de)
CA (1) CA2352562A1 (de)
CZ (1) CZ20011886A3 (de)
DE (1) DE69921192T2 (de)
DK (1) DK1152765T3 (de)
ES (1) ES2229804T3 (de)
HK (1) HK1043725B (de)
HU (1) HUP0104241A3 (de)
IL (1) IL143376A0 (de)
LV (1) LV12735B (de)
NZ (1) NZ512496A (de)
PL (1) PL197894B1 (de)
PT (1) PT1152765E (de)
RO (1) RO121408B1 (de)
RU (1) RU2240124C2 (de)
SI (1) SI20639A (de)
WO (1) WO2000032203A1 (de)
ZA (1) ZA200104312B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
PL197894B1 (pl) * 1998-11-30 2008-05-30 Teva Pharma Etanolan azytromycyny, sposób jego wytwarzania i zawierająca go kompozycja farmaceutyczna
WO2002042315A2 (en) * 2000-11-27 2002-05-30 Biochemie S.A. Macrolide solvates
RU2279439C2 (ru) * 2000-11-27 2006-07-10 Сандоз Аг Азитромицин в форме моногидрата и способ его получения
KR100431431B1 (ko) * 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
MXPA03010028A (es) * 2001-05-22 2004-02-12 Pfizer Prod Inc Formas cristalinas de azitromicina.
SI1390377T1 (sl) * 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1541134A3 (de) * 2001-10-18 2007-06-06 Teva Pharmaceutical Industries Limited Stabilisierte Azithromycin-Zusammensetzungen
US20080149521A9 (en) * 2001-10-18 2008-06-26 Michael Pesachovich Methods of stabilizing azithromycin
DE60232005D1 (de) 2001-10-18 2009-05-28 Teva Pharma Stabilisierte azithromycin-zusammensetzungen
PL371125A1 (en) * 2001-12-21 2005-06-13 Pfizer Products Inc. Methods for wet granulating azithromycin
CN1668282A (zh) * 2001-12-21 2005-09-14 辉瑞产品公司 可直接压制的阿齐霉素配方
WO2003063838A1 (en) * 2002-02-01 2003-08-07 Pfizer Products Inc. Dry granulated formulations of azithromycin
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
US20050101547A1 (en) * 2003-11-06 2005-05-12 Sadatrezaei Mohsen Stabilized azithromycin composition
KR20060092281A (ko) * 2003-12-04 2006-08-22 화이자 프로덕츠 인크. 액체 기초 방법에 의한 아지트로마이신 복합입자 투여형
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
DK1691787T3 (da) * 2003-12-04 2008-09-22 Pfizer Prod Inc Fremgangsmåde til at danne småpartikler
EP1689368B1 (de) * 2003-12-04 2016-09-28 Bend Research, Inc Sprüherstarrungsverfahren mit einem extruder zur herstellung von multiteilchenförmigen kristallinen arzneimittelzusammensetzungen
JP2007513139A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 安定性の改善した多粒子組成物
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
US7943585B2 (en) 2003-12-22 2011-05-17 Sandoz, Inc. Extended release antibiotic composition
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
JP2008524318A (ja) * 2004-12-21 2008-07-10 ファイザー・プロダクツ・インク 安定なアジスロマイシン非二水和物の経口用懸濁液剤
US20060198895A1 (en) * 2005-03-07 2006-09-07 Kotliar Eleonora M Azithromycin powder for oral suspension compositions
US20090318375A1 (en) * 2005-06-08 2009-12-24 Hanmi Pharm Co., Ltd Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same
CA2754604A1 (en) 2009-03-13 2010-09-16 Da Volterra Compositions and methods for elimination of gram-negative bacteria
EP3366326A1 (de) * 2009-04-17 2018-08-29 Micell Technologies, Inc. Stents mit gesteuerter elution
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN103983730B (zh) * 2014-06-11 2015-09-30 北京市药品检验所 阿奇霉素或其制剂中的杂质检查方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
MX12213A (es) 1987-07-09 1993-05-01 Pfizer Metodo de preparacion de dihidrato de azitromicina cristalino
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
CN1093370A (zh) * 1993-12-10 1994-10-12 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
CN1161971A (zh) * 1997-01-03 1997-10-15 石家庄制药集团有限公司 一种阿齐霉素结晶及其制备方法
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
PL197894B1 (pl) * 1998-11-30 2008-05-30 Teva Pharma Etanolan azytromycyny, sposób jego wytwarzania i zawierająca go kompozycja farmaceutyczna
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
MXPA03010028A (es) * 2001-05-22 2004-02-12 Pfizer Prod Inc Formas cristalinas de azitromicina.

Also Published As

Publication number Publication date
AU768219B2 (en) 2003-12-04
EP1152765B1 (de) 2004-10-13
PL347971A1 (en) 2002-05-06
US6365574B2 (en) 2002-04-02
CN1737008A (zh) 2006-02-22
AU3106500A (en) 2000-06-19
SI20639A (sl) 2002-02-28
WO2000032203A1 (en) 2000-06-08
KR100603226B1 (ko) 2006-08-28
PT1152765E (pt) 2004-12-31
LV12735B (en) 2002-03-20
AP2001002183A0 (en) 2001-06-30
JP2002531409A (ja) 2002-09-24
HK1043725A1 (en) 2002-09-27
CN1273142C (zh) 2006-09-06
CN1334735A (zh) 2002-02-06
CA2352562A1 (en) 2000-06-08
US20020007049A1 (en) 2002-01-17
EP1484062A1 (de) 2004-12-08
DK1152765T3 (da) 2005-01-31
AP1709A (en) 2007-02-27
DE69921192T2 (de) 2006-02-16
NZ512496A (en) 2003-02-28
EP1152765A4 (de) 2002-07-17
RO121408B1 (ro) 2007-05-30
BG105547A (en) 2001-12-31
CN100339384C (zh) 2007-09-26
DE69921192D1 (de) 2004-11-18
HUP0104241A2 (hu) 2002-03-28
ZA200104312B (en) 2001-11-28
HUP0104241A3 (en) 2003-12-29
LV12735A (en) 2001-10-20
PL197894B1 (pl) 2008-05-30
HK1043725B (en) 2005-05-06
IL143376A0 (en) 2002-04-21
ES2229804T3 (es) 2005-04-16
EP1152765A1 (de) 2001-11-14
CZ20011886A3 (cs) 2001-10-17
RU2240124C2 (ru) 2004-11-20
KR20010099806A (ko) 2001-11-09

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