ATE288280T1 - Verfahren zum blokieren von sec-rezeptoren - Google Patents
Verfahren zum blokieren von sec-rezeptorenInfo
- Publication number
- ATE288280T1 ATE288280T1 AT95931632T AT95931632T ATE288280T1 AT E288280 T1 ATE288280 T1 AT E288280T1 AT 95931632 T AT95931632 T AT 95931632T AT 95931632 T AT95931632 T AT 95931632T AT E288280 T1 ATE288280 T1 AT E288280T1
- Authority
- AT
- Austria
- Prior art keywords
- blocking
- sec
- receptors
- sec receptors
- peptide
- Prior art date
Links
- 230000000903 blocking effect Effects 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 108010005584 serpin-enzyme complex receptor Proteins 0.000 abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002887 neurotoxic effect Effects 0.000 abstract 1
- 239000012622 synthetic inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Indole Compounds (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/306,872 US5514653A (en) | 1994-09-09 | 1994-09-09 | Method of blocking the SEC receptor |
| PCT/US1995/010989 WO1996007425A1 (en) | 1994-09-09 | 1995-09-07 | Method of blocking the sec receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288280T1 true ATE288280T1 (de) | 2005-02-15 |
Family
ID=23187244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95931632T ATE288280T1 (de) | 1994-09-09 | 1995-09-07 | Verfahren zum blokieren von sec-rezeptoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5514653A (de) |
| EP (1) | EP0781143B1 (de) |
| JP (1) | JPH10505086A (de) |
| AT (1) | ATE288280T1 (de) |
| AU (1) | AU3498795A (de) |
| CA (1) | CA2199180A1 (de) |
| DE (1) | DE69533988D1 (de) |
| WO (1) | WO1996007425A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792749A (en) * | 1997-01-09 | 1998-08-11 | Virginia Commonwealth University | Method and composition for lowering low density lipoprotein cholesterol |
| DE19725619A1 (de) * | 1997-06-17 | 1998-12-24 | Fraunhofer Ges Forschung | Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien |
| US6849605B1 (en) | 1999-03-05 | 2005-02-01 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of viral infections |
| WO2000051625A1 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| WO2000051623A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions |
| AU3731400A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Methods and compositions useful in inhibiting apoptosis |
| JP2003532656A (ja) | 1999-12-23 | 2003-11-05 | ニューロケム インコーポレーティッド | 脳のアミロイド性脈管障害を調節するための化合物及び方法 |
| DE10148553A1 (de) * | 2001-10-01 | 2003-04-17 | Protagen Ag | Proteinaseinhibitoren zur Therapie und Diagnose von neurodegenerativen Krankheiten |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| JP2007504144A (ja) * | 2003-08-26 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティー オブ コロラド ア ボディー コーポレイト | セリンプロテアーゼ活性阻害因子、ならびに細菌感染の治療法および組成物におけるその使用方法 |
| KR20200044138A (ko) | 2011-06-24 | 2020-04-28 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| DK3381461T3 (da) | 2012-01-09 | 2021-05-17 | Serpin Pharma Llc | Peptider og fremgangsmåder til anvendelse deraf |
| JP2015504675A (ja) | 2012-01-10 | 2015-02-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | アルファ−１アンチトリプシン融合分子の組成物、方法、及び使用 |
| US10193357B2 (en) | 2013-06-26 | 2019-01-29 | Tws (Macau Commercial Offshore) Limited | Energy storage system |
| BR112018003928A2 (pt) | 2015-08-28 | 2018-09-25 | Serpin Pharma Llc | métodos para o tratamento de doenças |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| JPS60186290A (ja) * | 1983-08-10 | 1985-09-21 | チモ−ジエネテイツクス インコ−ポレ−テツド | アルフア−１−アンチトリプシンを細菌に表現させる方法 |
| US5157019A (en) * | 1986-03-18 | 1992-10-20 | Monsanto Company | Serine protease inhibitors |
| US5187153A (en) * | 1986-11-17 | 1993-02-16 | Scios Nova Inc. | Methods of treatment using Alzheimer's amyloid polypeptide derivatives |
| US5137873A (en) * | 1990-07-27 | 1992-08-11 | The Children's Medical Center Corporation | Substance p and tachykinin agonists for treatment of alzheimer's disease |
| US5164295A (en) * | 1991-03-06 | 1992-11-17 | The Upjohn Company | Method for identifying amyloid protein-extracellular matrix protein affinity altering compounds |
| US5175253A (en) * | 1991-04-24 | 1992-12-29 | Washington University | Binding peptides |
| US5604201A (en) * | 1993-01-08 | 1997-02-18 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization | Methods and reagents for inhibiting furin endoprotease |
-
1994
- 1994-09-09 US US08/306,872 patent/US5514653A/en not_active Expired - Fee Related
-
1995
- 1995-09-07 CA CA002199180A patent/CA2199180A1/en not_active Abandoned
- 1995-09-07 DE DE69533988T patent/DE69533988D1/de not_active Expired - Lifetime
- 1995-09-07 WO PCT/US1995/010989 patent/WO1996007425A1/en active IP Right Grant
- 1995-09-07 AT AT95931632T patent/ATE288280T1/de not_active IP Right Cessation
- 1995-09-07 JP JP8509559A patent/JPH10505086A/ja not_active Ceased
- 1995-09-07 AU AU34987/95A patent/AU3498795A/en not_active Abandoned
- 1995-09-07 EP EP95931632A patent/EP0781143B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69533988D1 (de) | 2005-03-10 |
| CA2199180A1 (en) | 1996-03-14 |
| WO1996007425A1 (en) | 1996-03-14 |
| JPH10505086A (ja) | 1998-05-19 |
| AU3498795A (en) | 1996-03-27 |
| EP0781143A1 (de) | 1997-07-02 |
| US5514653A (en) | 1996-05-07 |
| EP0781143B1 (de) | 2005-02-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE288280T1 (de) | Verfahren zum blokieren von sec-rezeptoren | |
| DE69530781D1 (de) | Verfahren zum beschichten von platinaluminid mit cvd | |
| DE69222396D1 (de) | Verfahren zum Aufbereiten von Kohlenwasserstoffen | |
| DE69735087D1 (de) | Verfahren zum Detektion von Methicillinresistenten Staphylococcen | |
| DE69411690D1 (de) | Verfahren zum Zementieren von unterirdischen Formationen | |
| DE69424076D1 (de) | Verfahren zum Nachweisen von Luciferase | |
| ATA148495A (de) | Verfahren zum verbrennen von brennstoff | |
| ATE168131T1 (de) | T-cadherin-bindungsmolekül | |
| DE59005201D1 (de) | Vefahren zum Abfangen von Schwefelwasserstoff mit Glyoxal. | |
| DE69622370D1 (de) | Verfahren zum behandeln von erdgas, das wasser und kondensierbare kohlenwasserstoffe enthält | |
| DE69426860D1 (de) | Stimmkodierer und Verfahren zum Suchen von Kodebüchern | |
| DE69018625D1 (de) | Verfahren zum aufkonzentrieren von chlorgas. | |
| DE69114199D1 (de) | Verfahren zum Zementieren von Öl- und Gasbohrlöchern. | |
| DE69522713D1 (de) | Verfahren zum assoziieren von datentragenden objekten mit objekten der benutzerschnittstelle | |
| DE69702586D1 (de) | Verfahren zum Acetoxylieren von Olefinen | |
| DE69610537D1 (de) | Verfahren zum Nachweis von Mikroorganismen | |
| DE69433479D1 (de) | Verfahren zum sanieren von abwassersystemen | |
| ATE194164T1 (de) | Verfahren zum nachweis von base reagierenden petroleumskraftstoffsmarkierungsmittel | |
| DE69801798D1 (de) | Verfahren zur Dehydrierung von gesättigten aliphatischen Kohlenwasserstoffen in olefinischen Kohlenwasserstoffen | |
| DE69604461D1 (de) | Verfahren zum Hydrophobieren von Leder | |
| DE69627517D1 (de) | Adaptiver regler zum spritzgiessen | |
| DE69615843D1 (de) | Il-8 antagonisten zur behandlung von asthma | |
| DE59601109D1 (de) | Verfahren zum behandeln von hausmüll | |
| DE69625024D1 (de) | Verfahren zum Nachweis von Protein im Harn | |
| DE58906497D1 (de) | Verfahren zum abdichten von schadhaften rohrleitungen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |