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ATE203025T1 - Reverse-turnmimetika und damit zusammenhängendes verfahren - Google Patents

Reverse-turnmimetika und damit zusammenhängendes verfahren

Info

Publication number
ATE203025T1
ATE203025T1 AT96937733T AT96937733T ATE203025T1 AT E203025 T1 ATE203025 T1 AT E203025T1 AT 96937733 T AT96937733 T AT 96937733T AT 96937733 T AT96937733 T AT 96937733T AT E203025 T1 ATE203025 T1 AT E203025T1
Authority
AT
Austria
Prior art keywords
reverse
turn mimetics
related method
reverse turn
disclosed
Prior art date
Application number
AT96937733T
Other languages
English (en)
Inventor
Michael Kahn
Original Assignee
Molecumetics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecumetics Ltd filed Critical Molecumetics Ltd
Application granted granted Critical
Publication of ATE203025T1 publication Critical patent/ATE203025T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Detergent Compositions (AREA)
  • Toys (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT96937733T 1995-10-27 1996-10-24 Reverse-turnmimetika und damit zusammenhängendes verfahren ATE203025T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/549,007 US5929237A (en) 1995-10-27 1995-10-27 Reverse-turn mimetics and methods relating thereto
PCT/US1996/017053 WO1997015577A1 (en) 1995-10-27 1996-10-24 Reverse-turn mimetics and methods relating thereto

Publications (1)

Publication Number Publication Date
ATE203025T1 true ATE203025T1 (de) 2001-07-15

Family

ID=24191284

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96937733T ATE203025T1 (de) 1995-10-27 1996-10-24 Reverse-turnmimetika und damit zusammenhängendes verfahren

Country Status (10)

Country Link
US (1) US5929237A (de)
EP (1) EP0876371B1 (de)
JP (1) JPH11513986A (de)
KR (1) KR19990067102A (de)
AT (1) ATE203025T1 (de)
AU (1) AU719620B2 (de)
CA (1) CA2235138C (de)
DE (1) DE69613861T2 (de)
ES (1) ES2158360T3 (de)
WO (1) WO1997015577A1 (de)

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US8163289B2 (en) * 2001-03-09 2012-04-24 Iterative Therapeutics, Inc. Methods and compositions involving polymeric immunoglobulin fusion proteins
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US7008941B2 (en) * 2001-05-16 2006-03-07 Myriad Genetics, Inc. Reverse-turn mimetics and methods relating thereto
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US6943157B2 (en) * 2001-10-09 2005-09-13 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
US20040072831A1 (en) * 2001-10-12 2004-04-15 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
JP4387793B2 (ja) * 2001-10-12 2009-12-24 チョンウェ ファーマ コーポレーション 逆向ターンミメティックおよびそれに関連した方法
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US7566711B2 (en) * 2001-10-12 2009-07-28 Choongwae Pharma Corporation Reverse-turn mimetics and method relating thereto
US7041499B2 (en) 2001-12-12 2006-05-09 University Of North Texas Health Science Center Immuno activation of CS1 receptor in natural killer cells to inhibit tumor cell growth
US6762185B1 (en) 2002-03-01 2004-07-13 Choongwae Pharma Corporation Compounds useful for treatment of cancer, compositions containing the same, and methods of their use
AU2003284120A1 (en) * 2002-10-17 2004-05-04 Myriad Genetics, Inc. Reverse-turn mimetics and composition and methods relating thereto
WO2005021025A2 (en) 2003-08-28 2005-03-10 Choongwae Pharma Corporation MODULATION OF β-CATENIN/TCF ACTIVATED TRANSCRIPTION
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US20050209256A1 (en) * 2004-03-19 2005-09-22 Andres Charles J Jr Novel beta-turn mimetics as calcitonin gene related peptide receptor antagonists
AU2006227776A1 (en) 2005-03-18 2006-09-28 Institute For Chemical Genomics Alpha-helix mimetics and methods relating to the treatment of fibrosis
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US7964181B2 (en) * 2006-03-30 2011-06-21 Palatin Technologies, Inc. Amino acid surrogates for peptidic constructs
US8580746B2 (en) * 2006-03-30 2013-11-12 Palatin Technologies, Inc. Amide linkage cyclic natriuretic peptide constructs
US8114844B2 (en) * 2006-03-30 2012-02-14 Palatin Technologies, Inc. Linear and cyclic melanocortin receptor-specific peptidomimetics
ATE543097T1 (de) 2006-07-27 2012-02-15 Univ Maryland Zellulärer rezeptor für antiproliferativen faktor
US8450481B2 (en) * 2007-06-14 2013-05-28 The Regents Of The University Of California Compounds for inhibiting protein aggregation, and methods for making and using them
JP2009040696A (ja) * 2007-08-07 2009-02-26 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド
EP2944649A1 (de) 2008-01-10 2015-11-18 Research Development Foundation Impfstoffe und diagnostika für ehrlichiosen
US8377925B2 (en) 2008-02-29 2013-02-19 Mimetica Pty Ltd Methods of modulating the activity of the MC5 receptor and treatment of conditions related to this receptor
US8343958B2 (en) 2008-02-29 2013-01-01 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5-receptor antagonists
US8008291B2 (en) 2008-02-29 2011-08-30 Mimetica Pty Ltd 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists
WO2009148192A1 (en) 2008-06-06 2009-12-10 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
US20110171164A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Polymer conjugates of glp-2-like peptides
EP2334338A2 (de) * 2008-09-19 2011-06-22 Nektar Therapeutics Polymerkonjugate von c-peptiden
WO2010033217A1 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of cd-np peptides
US20110171160A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Polymer conjugates of kiss1 peptides
AU2009292651A1 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of AOD-like peptides
EP2334336A1 (de) * 2008-09-19 2011-06-22 Nektar Therapeutics Polymerkonjugate von osteocalcin-peptiden
US20110171165A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Polymer conjugates of opioid growth factor peptides
EP2344199A1 (de) * 2008-09-19 2011-07-20 Nektar Therapeutics Polymer-konjugate von thymosin-alpha1-peptiden
MX2011003117A (es) 2008-09-19 2011-04-21 Nektar Therapeutics Conjugados polimericos de peptidos terapeuticos.
US20110171312A1 (en) * 2008-09-19 2011-07-14 Nektar Therapeutics Modified therapeutic peptides, methods of their preparation and use
WO2010044485A1 (en) 2008-10-14 2010-04-22 Prism Biolab Corporation Alpha helix mimetics in the treatment of cancer
CN102245632B (zh) 2008-10-17 2018-10-12 达娜-法勃肿瘤研究所公司 Muc-1胞质结构域肽作为癌症的抑制剂
EP2419430A4 (de) * 2009-04-15 2012-10-31 Jw Pharmaceutical Corp Neue reverse-turn-mimetikaverbindungen, verfahren zu ihrer herstellung und verwendung
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JPWO2011096440A1 (ja) 2010-02-03 2013-06-10 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ 天然変性タンパク質に結合する化合物およびそのスクリーニング方法
US8952054B2 (en) 2010-03-15 2015-02-10 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of MUC1 and methods of identifying the same
WO2012050393A2 (ko) 2010-10-14 2012-04-19 제이더블유중외제약 주식회사 리버스-턴 유사체의 신규한 화합물 및 그 제조방법과 용도
CN103517904A (zh) 2011-02-25 2014-01-15 株式会社棱镜制药 α-螺旋模拟物和与其相关的方法
CA2832443C (en) 2011-04-06 2020-08-25 The Board Of Regents Of The University Of Texas System Modulating bacterial mam polypeptides in pathogenic disease
WO2013018097A2 (en) 2011-08-01 2013-02-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Novel sequences for the control of reproduction in fish
WO2013026015A1 (en) 2011-08-18 2013-02-21 Dana-Farber Cancer Institute, Inc. Muc1 ligand traps for use in treating cancers
WO2014045126A2 (en) 2012-09-18 2014-03-27 Uti Limited Partnership Treatment of pain by inhibition of usp5 de-ubiquitinase
US9572855B2 (en) 2013-03-11 2017-02-21 Dana-Farber Cancer Institute, Inc. Combination anti-estrogen receptor cancer therapy using MUC1 peptides and chemotherapeutics
US9789156B2 (en) 2013-03-11 2017-10-17 Dana-Farber Cancer Institute, Inc. Combination anti-human epidermal growth factor receptor 2 (anti-HER2) cancer therapy using mucin 1 (MUC1) peptides and hemotherapeutics
HUE062055T2 (hu) 2013-03-15 2023-09-28 Gladiator Biosciences Inc GLA domének mint terápiás szerek
EP3057590B1 (de) 2013-10-18 2019-11-27 PRISM BioLab Co., Ltd. Behandlung von lungenfibrose mit einem cbp-/catenin-hemmer
WO2018035429A1 (en) 2016-08-18 2018-02-22 Wisconsin Alumni Research Foundation Peptides that inhibit syndecan-1 activation of vla-4 and igf-1r
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WO2022092294A1 (ja) 2020-10-30 2022-05-05 学校法人慶應義塾 サルコペニア関連疾患等の新規治療および予防
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CA2141447A1 (en) * 1992-08-06 1994-02-17 Michael Kahn Conformationally restricted mimetics of reverse turns and peptides containing the same
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Also Published As

Publication number Publication date
WO1997015577A1 (en) 1997-05-01
CA2235138A1 (en) 1997-05-01
EP0876371A1 (de) 1998-11-11
ES2158360T3 (es) 2001-09-01
US5929237A (en) 1999-07-27
JPH11513986A (ja) 1999-11-30
CA2235138C (en) 2005-04-05
KR19990067102A (ko) 1999-08-16
AU7520596A (en) 1997-05-15
AU719620B2 (en) 2000-05-11
DE69613861T2 (de) 2001-11-15
EP0876371B1 (de) 2001-07-11
DE69613861D1 (de) 2001-08-16

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties