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ATE205399T1 - Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält - Google Patents

Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält

Info

Publication number
ATE205399T1
ATE205399T1 AT95938085T AT95938085T ATE205399T1 AT E205399 T1 ATE205399 T1 AT E205399T1 AT 95938085 T AT95938085 T AT 95938085T AT 95938085 T AT95938085 T AT 95938085T AT E205399 T1 ATE205399 T1 AT E205399T1
Authority
AT
Austria
Prior art keywords
pct
thrombin inhibitor
storage
solution containing
stable aqueous
Prior art date
Application number
AT95938085T
Other languages
English (en)
Inventor
Ulla Stjernfelt
Mats Sundgren
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE205399T1 publication Critical patent/ATE205399T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95938085T 1994-11-08 1995-10-19 Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält ATE205399T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer
PCT/SE1995/001228 WO1996014084A1 (en) 1994-11-08 1995-10-19 A storage stable water solution for infusion containing a thrombin inhibitor

Publications (1)

Publication Number Publication Date
ATE205399T1 true ATE205399T1 (de) 2001-09-15

Family

ID=20395892

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95938085T ATE205399T1 (de) 1994-11-08 1995-10-19 Eine lagerstabile wässrige lösung zur infusion die einen thrombininhibitor enthält

Country Status (31)

Country Link
US (1) US5830865A (de)
EP (1) EP0789585B1 (de)
JP (1) JPH10508598A (de)
KR (1) KR100416677B1 (de)
CN (1) CN1090508C (de)
AT (1) ATE205399T1 (de)
AU (1) AU695719B2 (de)
BR (1) BR9509634A (de)
CA (1) CA2203396A1 (de)
CZ (1) CZ287256B6 (de)
DE (1) DE69522702T2 (de)
DK (1) DK0789585T3 (de)
EE (1) EE9700218A (de)
ES (1) ES2163528T3 (de)
FI (1) FI971949A7 (de)
HU (1) HU217073B (de)
IL (1) IL115879A (de)
IS (1) IS4468A (de)
MX (1) MX9703339A (de)
MY (1) MY112593A (de)
NO (1) NO322048B1 (de)
NZ (1) NZ295492A (de)
PL (1) PL320342A1 (de)
PT (1) PT789585E (de)
RU (1) RU2164803C2 (de)
SE (1) SE504185C2 (de)
SK (1) SK53597A3 (de)
TR (1) TR199501391A2 (de)
TW (1) TW407057B (de)
WO (1) WO1996014084A1 (de)
ZA (1) ZA959377B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984627B1 (en) * 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
TW541316B (en) * 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9802974D0 (sv) * 1998-09-03 1998-09-03 Astra Ab New crystalline forms
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
US7479502B2 (en) 2002-12-03 2009-01-20 Pharmacyclics, Inc. 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US8591942B2 (en) * 2009-09-23 2013-11-26 Indu JAVERI Methods for the preparation of liposomes comprising docetaxel
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes
MX2021008557A (es) * 2021-01-13 2021-11-17 Grupo Ion Biotech S A P I De C V Sistema de suministro de ionoforos quimicos de membrana celular sintetica que comprende composiciones de ligandos hexa-acuaticos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2096415C1 (ru) * 1991-09-30 1997-11-20 Дзе Дюпон Мерк Фармасьютикал Компани Циклические пептиды или их фармацевтически приемлемые соли, фармацевтическая композиция
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US5466131A (en) * 1994-03-22 1995-11-14 Micropump Corporation Multiple-chamber gear pump with hydraulically connected chambers

Also Published As

Publication number Publication date
NO972065L (no) 1997-05-05
MY112593A (en) 2001-07-31
DE69522702T2 (de) 2002-07-11
SE9403831L (sv) 1996-05-09
CZ287256B6 (en) 2000-10-11
JPH10508598A (ja) 1998-08-25
MX9703339A (es) 1997-07-31
FI971949A0 (fi) 1997-05-07
SE504185C2 (sv) 1996-12-02
TR199501391A2 (tr) 1996-06-21
EP0789585B1 (de) 2001-09-12
SE9403831D0 (sv) 1994-11-08
DE69522702D1 (de) 2001-10-18
TW407057B (en) 2000-10-01
IS4468A (is) 1997-04-21
CN1090508C (zh) 2002-09-11
NO322048B1 (no) 2006-08-07
EP0789585A1 (de) 1997-08-20
ES2163528T3 (es) 2002-02-01
NZ295492A (en) 1998-06-26
PT789585E (pt) 2002-01-30
KR970706844A (ko) 1997-12-01
EE9700218A (et) 1998-02-16
WO1996014084A1 (en) 1996-05-17
SK53597A3 (en) 1998-07-08
RU2164803C2 (ru) 2001-04-10
KR100416677B1 (ko) 2004-06-16
FI971949L (fi) 1997-05-07
CA2203396A1 (en) 1996-05-17
DK0789585T3 (da) 2001-11-12
IL115879A (en) 2001-08-08
CN1162921A (zh) 1997-10-22
BR9509634A (pt) 1998-01-06
PL320342A1 (en) 1997-09-29
IL115879A0 (en) 1996-01-31
AU695719B2 (en) 1998-08-20
NO972065D0 (no) 1997-05-05
AU3884695A (en) 1996-05-31
US5830865A (en) 1998-11-03
CZ129497A3 (cs) 1998-02-18
FI971949A7 (fi) 1997-05-07
HU217073B (hu) 1999-11-29
ZA959377B (en) 1996-05-08
HUT77560A (hu) 1998-06-29

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