[go: up one dir, main page]

ATE206395T1 - Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden - Google Patents

Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden

Info

Publication number
ATE206395T1
ATE206395T1 AT91912121T AT91912121T ATE206395T1 AT E206395 T1 ATE206395 T1 AT E206395T1 AT 91912121 T AT91912121 T AT 91912121T AT 91912121 T AT91912121 T AT 91912121T AT E206395 T1 ATE206395 T1 AT E206395T1
Authority
AT
Austria
Prior art keywords
fluorescent
polyol
phthalocyanine
polyethylene glycol
porphyrin
Prior art date
Application number
AT91912121T
Other languages
English (en)
Inventor
Peter Olof Gustaf Arrhenius
Original Assignee
Hyperion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperion Inc filed Critical Hyperion Inc
Application granted granted Critical
Publication of ATE206395T1 publication Critical patent/ATE206395T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0015—Phosphorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/06—Preparation from carboxylic acids or derivatives thereof, e.g. anhydrides, amides, mononitriles, phthalimide, o-cyanobenzamide
    • C09B47/073—Preparation from isoindolenines, e.g. pyrrolenines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/08—Preparation from other phthalocyanine compounds, e.g. cobaltphthalocyanineamine complex
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C09B47/04—Phthalocyanines abbreviation: Pc
    • C09B47/08—Preparation from other phthalocyanine compounds, e.g. cobaltphthalocyanineamine complex
    • C09B47/24—Obtaining compounds having —COOH or —SO3H radicals, or derivatives thereof, directly bound to the phthalocyanine radical
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G01N2333/19—Rubella virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
AT91912121T 1990-05-15 1991-05-15 Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden ATE206395T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52360190A 1990-05-15 1990-05-15
PCT/US1991/003424 WO1991018006A1 (en) 1990-05-15 1991-05-15 Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes

Publications (1)

Publication Number Publication Date
ATE206395T1 true ATE206395T1 (de) 2001-10-15

Family

ID=24085661

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91912121T ATE206395T1 (de) 1990-05-15 1991-05-15 Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden

Country Status (7)

Country Link
US (1) US5403928A (de)
EP (1) EP0529002B1 (de)
JP (1) JP3224538B2 (de)
AT (1) ATE206395T1 (de)
DE (1) DE69132750T2 (de)
ES (1) ES2163393T3 (de)
WO (1) WO1991018006A1 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648270A (en) * 1995-02-06 1997-07-15 Molecular Probes, Inc. Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
US5641878A (en) * 1991-05-15 1997-06-24 Diatron Corporation Porphyrin, azaporphyrin, and related fluorescent dyes free of aggregation and serum binding
US5606045A (en) * 1990-05-15 1997-02-25 Diatron Corporation Nucleic acid probes and methods
US5880287A (en) * 1990-05-15 1999-03-09 Hyperion, Inc. Polyoxyhydrocarbyl related products and methods for fluorescence assays
US6060598A (en) * 1990-05-15 2000-05-09 Hyperion, Inc. Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
US5919922A (en) * 1990-05-15 1999-07-06 Hyperion, Inc. Fluorescent dyes free of aggregation and serum binding
US5846703A (en) * 1990-05-15 1998-12-08 Diatron Corporation Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
FR2680787B1 (fr) * 1991-08-30 1994-11-04 Cis Bio Int Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence.
TW235298B (de) * 1992-02-27 1994-12-01 Ciba Geigy
CA2132708C (en) * 1992-03-23 2005-05-10 Robert F. Devlin Fluorescence immunoassays using fluorescent dyes free of aggregation and serum binding
US5371199B1 (en) * 1992-08-14 1995-12-26 Univ Pennsylvania Substituted porphyrins porphyrin-containing polymers and synthetic methods therefor
US5493017A (en) * 1992-08-14 1996-02-20 The Trustees Of The University Of Pennsylvania Ring-metalated porphyrins
US5599924A (en) * 1992-08-14 1997-02-04 Trustees Of The University Of Pennsylvania Electron-deficient porphyrins and processes and intermediates for preparing same
US5817830A (en) * 1992-08-14 1998-10-06 Trustees Of The University Of Pennsylvania Pyrrolic compounds
JP3218770B2 (ja) * 1993-01-14 2001-10-15 富士ゼロックス株式会社 電子写真感光体とそのためのフタロシアニン顔料および顔料分散液
US7322927B2 (en) 1993-09-24 2008-01-29 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US6238931B1 (en) * 1993-09-24 2001-05-29 Biosite Diagnostics, Inc. Fluorescence energy transfer in particles
US5824799A (en) * 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
EP0649667B1 (de) * 1993-10-20 2001-02-28 Antonella Aprile Carpenter Gerät zur therapeutischen Biostimulation mittels Quantenenergie
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5679661A (en) * 1995-07-25 1997-10-21 The Procter & Gamble Company Low hue photodisinfectants
US5916481A (en) * 1995-07-25 1999-06-29 The Procter & Gamble Company Low hue photobleaches
US5763602A (en) * 1996-10-01 1998-06-09 Li; Ying-Syi Methods of syntheses of phthalocyanine compounds
CA2277810A1 (en) 1997-01-24 1998-07-30 The Procter & Gamble Company Photobleaching compositions effective on dingy fabric
CA2277921A1 (en) 1997-01-24 1998-07-30 The Procter & Gamble Company Low hue photobleaches
JP2001512498A (ja) 1997-01-24 2001-08-21 ザ、プロクター、エンド、ギャンブル、カンパニー 向上した重原子効果を有する一重項酸素発生剤
JP2001509194A (ja) 1997-01-24 2001-07-10 ザ、プロクター、エンド、ギャンブル、カンパニー カチオン付着性調整基を有した光化学一重項酸素発生剤
JP2001511198A (ja) 1997-01-24 2001-08-07 ザ、プロクター、エンド、ギャンブル、カンパニー 混合メタロシアニンを含んだ光漂白組成物
ZA98529B (en) 1997-01-24 1998-07-29 Procter & Gamble Photochemical superoxide generators
JP2001511197A (ja) 1997-01-24 2001-08-07 ザ、プロクター、エンド、ギャンブル、カンパニー 向上した一重項酸素収率を有する光化学一重項酸素発生剤
US6544797B1 (en) * 1997-04-09 2003-04-08 Biosite Diagnostics, Inc. Compositions and methods for inhibiting light-induced inactivation of biological reagents
US6165741A (en) * 1997-05-30 2000-12-26 The Trustees Of The University Of Pennsylvania Method for rapid detection of bacterial growth in cultures
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US20050227294A1 (en) * 1997-09-15 2005-10-13 Molecular Devices Corporation Molecular modification assays involving lipids
US7745142B2 (en) * 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6033918A (en) * 1997-11-10 2000-03-07 Bayer Corporation Method and device for the detection of analyte in a fluid sample
US5990486A (en) * 1997-11-21 1999-11-23 University Of Massachusetts Apparatus and method for measuring components of a solute stream
WO1999051284A2 (en) * 1998-04-03 1999-10-14 Mallinckrodt Inc. Non-covalent bioconjugates useful for diagnosis and therapy
GB2337523A (en) * 1998-04-29 1999-11-24 Nycomed Imaging As Light imaging contrast agents
US6592847B1 (en) * 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6630128B1 (en) 1998-08-28 2003-10-07 Destiny Pharma Limited Porphyrin derivatives their use in photodynamic therapy and medical devices containing them
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
EA200200635A1 (ru) * 1999-12-15 2002-12-26 Шеринг Акциенгезельшафт Флуоресцентный контрастный агент для ближней инфракрасной области спектра и способ флуоресцентной визуализации
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
EP1412749A4 (de) * 2001-06-28 2006-12-13 Ia Inc Faseroptisches sensorarray
JP5000050B2 (ja) * 2001-08-31 2012-08-15 浩 前田 抗腫瘍剤及びその製造方法
EP1485716A1 (de) * 2002-03-11 2004-12-15 Visen Medical, Inc. Sonden zur erzeugung von optischen bildern
US7005518B2 (en) * 2002-10-25 2006-02-28 Li-Cor, Inc. Phthalocyanine dyes
US7371524B2 (en) * 2003-06-17 2008-05-13 Hannjorg Hereth Substituted azaporphyrins as fluorescence labels
US20070238921A1 (en) * 2004-11-01 2007-10-11 Weirich John P Capsule imaging device using fluorescent light
US7601498B2 (en) * 2005-03-17 2009-10-13 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection and associated technology
US7776567B2 (en) * 2005-03-17 2010-08-17 Biotium, Inc. Dimeric and trimeric nucleic acid dyes, and associated systems and methods
WO2007002332A2 (en) * 2005-06-21 2007-01-04 Mallinckrodt Inc. Optical imaging contrast agents
EP1780213A1 (de) * 2005-10-27 2007-05-02 3M Innovative Properties Company Silizium-Harnstoffazoliden, deren Herstellung und deren Verwendung zur Herstellung von Isocyanatendgruppen tragenden Siliconen
US8092784B2 (en) 2005-11-30 2012-01-10 Biotium, Inc. Enzyme substrate comprising a functional dye and associated technology and methods
US20080003694A1 (en) * 2006-04-18 2008-01-03 Swanson Basil I Robust, self-assembled, biocompatible films
US9193746B2 (en) * 2006-12-07 2015-11-24 Biotium, Inc. Luminescent metal complexes and associated technology
ES2535958T3 (es) 2008-01-18 2015-05-19 Visen Medical, Inc. Agentes de imaginología fluorescentes
DK2250223T3 (en) * 2008-02-06 2017-02-06 Barry J Noar Method of incorporating compound into matrices
ES2704644T3 (es) * 2008-08-22 2019-03-19 Medibeacon Inc Medición transcutánea de función orgánica
DE102009018688B4 (de) 2009-04-23 2017-03-02 Knauf Insulation Mineralwolleprodukt
US8877437B1 (en) 2009-12-23 2014-11-04 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection
CN102676154B (zh) * 2011-03-11 2014-01-29 清华大学 磷类酞菁及其衍生物作为荧光探针的应用
CN102757437B (zh) * 2012-06-12 2014-10-15 中国科学院化学研究所 酞菁纳米棒阵列薄膜及其制备方法与应用
AU2018213422B2 (en) 2017-01-30 2020-02-06 Medibeacon Inc. Method for non-invasive monitoring of fluorescent tracer agent with diffuse reflection corrections
JP2024516546A (ja) * 2021-04-09 2024-04-16 ラクテン・メディカル，インコーポレイテッド フタロシアニン色素化合物、コンジュゲート及びその使用方法
EP4299761A1 (de) * 2022-06-30 2024-01-03 betaSENSE GmbH Oberflächenfunktionalisiertes optisches element
USD1051738S1 (en) 2023-01-06 2024-11-19 Medibeacon Inc. Sensor ring
USD1052412S1 (en) 2023-01-06 2024-11-26 Medibeacon Inc. Sensor

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2951797A (en) * 1957-11-13 1960-09-06 Monsanto Chemicals Photosensitizers in photoxidation
US3116256A (en) * 1961-08-24 1963-12-31 Lawter Chem Inc Daylight fluorescent compositions
US3287470A (en) * 1962-07-10 1966-11-22 Geigy Ag J R Metal phthalocyanine dyestuffs
US4104466A (en) * 1974-03-13 1978-08-01 Eishun Tsuchida Polymeric metal complex and method of manufacturing the same
US4404366A (en) * 1980-05-06 1983-09-13 Miles Laboratories, Inc. Beta-galactosyl-umbelliferone-labeled hapten conjugates
US4707454A (en) * 1981-08-10 1987-11-17 Bio-Diagnostics, Inc. Fluorescent chlorophyll labeled assay reagents
EP0127797B1 (de) * 1983-06-03 1987-06-16 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Markermoleküle für Fluoreszenz-Immuno-Assays sowie Verfahren und Zwischenprodukte zu deren Herstellung
US5059510A (en) * 1985-02-04 1991-10-22 Hoechst Celanese Corp. Media for optical information storage comprising an organic macrocyclic chromophore substituted with a film conferring organic substituent
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4732570A (en) * 1985-09-13 1988-03-22 Milliken Research Corporation Colored thermoplastic resin
EP0220686B1 (de) * 1985-10-23 1992-12-30 Nihon Medi-Physics Co., Ltd. Porphyrinderivate, ihre Herstellung und Verwendung
JPH0645681B2 (ja) * 1986-02-05 1994-06-15 美浜 久春 修飾ヘム
JPS62249986A (ja) * 1986-04-21 1987-10-30 Hamari Yakuhin Kogyo Kk ポルフイリン誘導体
US4877872A (en) * 1986-06-24 1989-10-31 The University Of Toledo Production and use of dimers of hematoporophyrin, purpurins, chlorines and purpurin- and chlorin-complexes
US4814098A (en) * 1986-09-06 1989-03-21 Bellex Corporation Magnetic material-physiologically active substance conjugate
US5135717A (en) * 1986-12-24 1992-08-04 British Technology Group Usa Inc. Tetrabenztriazaporphyrin reagents and kits containing the same
JPH07100714B2 (ja) * 1987-03-03 1995-11-01 株式会社三和化学研究所 ランプテロフラビン及びその製法
JPH0778180B2 (ja) * 1987-04-22 1995-08-23 東洋インキ製造株式会社 顔料組成物
DE3809671A1 (de) * 1988-03-18 1989-09-28 Schering Ag Porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5177200A (en) * 1989-05-19 1993-01-05 Milliken Research Corporation Poly(oxyalkylene) modified phthalocyanine colorants
US5053423A (en) * 1990-03-22 1991-10-01 Quadra Logic Technologies Inc. Compositions for photodynamic therapy

Also Published As

Publication number Publication date
EP0529002A1 (de) 1993-03-03
EP0529002B1 (de) 2001-10-04
WO1991018006A1 (en) 1991-11-28
JP3224538B2 (ja) 2001-10-29
DE69132750T2 (de) 2002-06-20
JPH05508015A (ja) 1993-11-11
EP0529002A4 (en) 1995-09-13
US5403928A (en) 1995-04-04
ES2163393T3 (es) 2002-02-01
DE69132750D1 (de) 2001-11-08

Similar Documents

Publication Publication Date Title
ATE206395T1 (de) Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden
CA2082936A1 (en) Fluorescent porphyrin, and fluorescent phthalocyanine-polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
EP0528991A4 (en) Phthalocyanatopolyethylene glycol, and phthalocyanato saccharides as fluorescent digoxin reagents
BG100194A (bg) Трициклополиазамакроциклофосфонови киселини,техни производни и комплекси и използването им като контрастни средства
BR0211150A (pt) Complexos metálicos macrocìclicos conjugados e uso dos mesmos para produção de agentes para o diagnóstico de rmn e radiodiagnóstico, bem como radioterapia
ES2173128T3 (es) Conjugados para el anclaje celular y de proteinas sericas.
BG100192A (en) 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
SG46455A1 (en) Intraoperative and endoscopic tumor detection and therapy
CY1116265T1 (el) Kit ραδιοεπισημανσης και προσδιορισμος δεσμευσης
DE3484980D1 (de) Lokalisierung von krebsgewebe durch nachweis von infrarot-fluoreszenz durch intravenoes eingespritztes porphyrin in tumorspezifischen markierungen angeregt durch langwellenlicht.
CY1109744T1 (el) Συζυγη και μεθοδοι για την παραγωγη τους, και η χρηση τους για την μεταφορα μοριων δια μεσου βιολογικων μεμβρανων
WO2002031209A3 (en) Genes related to development of refractory prostate cancer
DE60113445D1 (de) Substanzen mit verzweigten linkermolekülen
EA200200808A1 (ru) Модифицированные цитокины, предназначенные для применения в терапии рака
GT200200038A (es) Conjugados peg de hgf-nk4
DK0566571T3 (da) Diagnose af metastatisk cancer ved hjælp af mts-1-genet
DE69230970D1 (de) Bicylclische, polyazamakrocyclocarbonsäure-komplexe, konjugate, herstellung und verwendung als kontraststoffe
SE8002831L (sv) Oxitetracyklinberedningar
ATE277352T1 (de) Einetenascin-c isoform als marker für neoplasmen
ES3036313T3 (en) Narrow emission dyes, compositions comprising same, and methods for making and using same
BR0207327A (pt) Amino derivados de biotina e seus conjugados com agentes quelantes macrocìclicos
ATE288960T1 (de) Humanisierte monoklonale antikörper mit hoher affinität gegen tag-72
NO954442L (no) Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler, og fremgangsmåter for deres fremstilling
AR024114A1 (es) Antigeno (c42) asociado a tumores
ES2039211T3 (es) Nuevos n-glicosilamidoderivados, procedimientos para su obtencion y su empleo como medicamentos.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties