ATE210640T1 - Modifizierte mehrfach ungesättigte fettsäuren - Google Patents
Modifizierte mehrfach ungesättigte fettsäurenInfo
- Publication number
- ATE210640T1 ATE210640T1 AT95933988T AT95933988T ATE210640T1 AT E210640 T1 ATE210640 T1 AT E210640T1 AT 95933988 T AT95933988 T AT 95933988T AT 95933988 T AT95933988 T AT 95933988T AT E210640 T1 ATE210640 T1 AT E210640T1
- Authority
- AT
- Austria
- Prior art keywords
- fatty acid
- polyunsaturated fatty
- oxa
- provides
- fatty acids
- Prior art date
Links
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 title abstract 5
- 238000006467 substitution reaction Methods 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 241000534944 Thia Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 hydroxy, hydroperoxy, peroxy, carboxymethyl Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 125000000864 peroxy group Chemical group O(O*)* 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 abstract 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C409/00—Peroxy compounds
- C07C409/02—Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides
- C07C409/04—Peroxy compounds the —O—O— group being bound between a carbon atom, not further substituted by oxygen atoms, and hydrogen, i.e. hydroperoxides the carbon atom being acyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C409/00—Peroxy compounds
- C07C409/16—Peroxy compounds the —O—O— group being bound between two carbon atoms not further substituted by oxygen atoms, i.e. peroxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C409/00—Peroxy compounds
- C07C409/40—Peroxy compounds containing nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C409/00—Peroxy compounds
- C07C409/42—Peroxy compounds containing sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPM8781A AUPM878194A0 (en) | 1994-10-13 | 1994-10-13 | Modified fatty acids in the treatment of inflammation |
| AUPM9066A AUPM906694A0 (en) | 1994-10-26 | 1994-10-26 | Novel compounds for treating malaria and other diseases |
| PCT/AU1995/000677 WO1996011908A1 (en) | 1994-10-13 | 1995-10-13 | Modified polyunsaturated fatty acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210640T1 true ATE210640T1 (de) | 2001-12-15 |
Family
ID=25644792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95933988T ATE210640T1 (de) | 1994-10-13 | 1995-10-13 | Modifizierte mehrfach ungesättigte fettsäuren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6376688B1 (de) |
| EP (1) | EP0869941B1 (de) |
| JP (1) | JPH10507179A (de) |
| KR (1) | KR100463709B1 (de) |
| CN (1) | CN1088058C (de) |
| AT (1) | ATE210640T1 (de) |
| CA (1) | CA2202503C (de) |
| DE (1) | DE69524639T2 (de) |
| WO (1) | WO1996011908A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997038688A1 (en) | 1996-04-12 | 1997-10-23 | Peptide Technology Pty. Limited | Methods of treating immunopathologies using polyunsaturated fattyacids |
| DE19649869A1 (de) * | 1996-12-02 | 1998-06-04 | Biotechnolog Forschung Gmbh | Ungesättigte aliphatische Carbonsäuren (Maracenine), Herstellungsverfahren und Mittel |
| AU784116B2 (en) * | 1999-09-17 | 2006-02-09 | Peplin Biolipids Pty Ltd | Anti-cancer nitro- and thia-fatty acids |
| AUPQ291499A0 (en) * | 1999-09-17 | 1999-10-07 | Women's And Children's Hospital Adelaide | Novel nitro and sulphur containing compounds |
| NO328803B1 (no) * | 2000-03-03 | 2010-05-18 | Thia Medica | Nye fettsyreanaloger |
| NO20006008L (no) * | 2000-11-28 | 2002-05-29 | Thia Medica As | Fettsyreanaloger for behandling av inflammatoriske og autoimmune sykdommer |
| AU2002352726A1 (en) | 2001-11-15 | 2003-06-10 | Galileo Laboratories, Inc. | Formulations and methods for treatment or amelioration of inflammatory conditions |
| US20040002514A1 (en) * | 2002-06-14 | 2004-01-01 | Alcon, Inc. | Topical use of hydroxyeicosatetraenoic acid compounds to treat psoriasis |
| EP1583527A1 (de) | 2002-06-14 | 2005-10-12 | Alcon, Inc. | Verwendung von hydroxyeicosatetraensäure verbindungen zur behandlung augenentzendungen |
| WO2004000854A1 (en) | 2002-06-20 | 2003-12-31 | Ic Vec Limited | Sulfur-containing phospholipid derivatives |
| EP1718602A4 (de) * | 2004-01-30 | 2007-12-12 | Peplin Biolipids Pty Ltd | Therapeutische und trägermoleküle |
| WO2007131959A1 (en) * | 2006-05-12 | 2007-11-22 | Nuplex Resins B.V. | Aqueous dispersion of an auto-oxidatively drying polyurethane |
| BRPI0717972A2 (pt) * | 2006-11-01 | 2013-11-12 | Pronova Biopharma Norge As | Lipídeos de ômega-3 alfa-substituídos que são ativadores ou moduladores do receptor ativado por proliferadores de peroxissoma (ppar) |
| US20100104546A1 (en) * | 2007-02-05 | 2010-04-29 | Children, Youth And Women's Health Service | Modulators of antigen-dependent t cell proliferation |
| WO2009017802A1 (en) | 2007-08-01 | 2009-02-05 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Nitro-fattyacid modulation of type ii diabetes |
| WO2009134383A2 (en) | 2008-05-01 | 2009-11-05 | Complexa Inc. | Vinyl substituted fatty acids |
| GB2460056A (en) * | 2008-05-14 | 2009-11-18 | Arab Science & Technology Foun | Compositions comprising omega-6 fatty acids for use in treating schistosomiasis |
| EP2299997A4 (de) | 2008-06-19 | 2012-01-11 | Univ Utah Res Found | Verwendung von nitrierten lipiden zur behandlung von nebenwirkungen von toxischen medizinischen therapien |
| US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| EP2147910A1 (de) * | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Neue Lipid-Verbindungen |
| EP2208720A1 (de) | 2009-01-13 | 2010-07-21 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Neuartige Eicosanoidderivate |
| EP2427415B1 (de) | 2009-05-08 | 2019-03-20 | Basf As | Mehrfach ungesättigte fettsäuren zur behandlung von erkrankungen im zusammenhang mit herz-kreislauf-, stoffwechsel- und entzündungspathologie |
| US9066902B2 (en) | 2009-07-31 | 2015-06-30 | University of Pittsburgh—of the Commonwealth System of Higher Education | Fatty acids as anti-inflammatory agents |
| EP2483233A4 (de) * | 2009-10-02 | 2013-08-14 | Complexa Inc | Heteroatom mit substituierten fettsäuren |
| MY170076A (en) | 2010-11-05 | 2019-07-03 | Pronova Biopharma Norge As | Methods of treatment using lipid compounds |
| EP2744491B1 (de) | 2011-08-19 | 2020-07-29 | The University of Utah Research Foundation | Kombinationstherapie mit nitrierten lipiden und inhibitoren des renin-angiotensin-aldosteron-systems |
| JP6537980B2 (ja) | 2013-02-28 | 2019-07-03 | プロノヴァ・バイオファーマ・ノルゲ・アーエスPronova BioPharma Norge AS | 脂質化合物、トリグリセリドおよび界面活性剤を含む組成物、ならびにその使用方法 |
| WO2015063617A2 (en) * | 2013-10-29 | 2015-05-07 | Dignity Sciences Limited | Methods of making 15-hydroxy fatty acid derivatives |
| US20180104201A1 (en) | 2015-04-28 | 2018-04-19 | Pronova Biopharma Norge As | Use of structurally enhanced fatty acids containing sulphur for preventing and or treating non alcoholic steatohepatitis |
| EP3303339B1 (de) | 2015-07-07 | 2021-01-13 | H. Lundbeck A/S | Pde9-inhibitoren mit imidazotriazinon-backbone und imidazopyrazinon-backbone zur behandlung von peripheren erkrankungen |
| MX2018004043A (es) | 2015-10-02 | 2018-11-09 | Complexa Inc | Prevencion, tratamiento y reversion de enfermedad usando cantidades terapeuticamente efectivas de acidos grasos activados. |
| GB201521085D0 (en) * | 2015-11-30 | 2016-01-13 | Biozep As | Use |
| US11111222B2 (en) | 2016-06-23 | 2021-09-07 | The Regents Of The University Of Michigan | Hydroxyeicosatrienoic acid compounds and their use as therapeutic agents |
| HUE069832T2 (hu) | 2017-12-06 | 2025-04-28 | Basf As | Zsírsav-származékok a nem alkoholos steatohepatitis kezelésére |
| WO2019226944A1 (en) | 2018-05-25 | 2019-11-28 | Imara Inc. | Monohydrate and crystalline forms of 6-[(3s,4s)-4-methyl-1- (pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl- 7h-imid azo [1,5- a] pyrazin-8-one |
| CN119679736A (zh) | 2018-08-31 | 2025-03-25 | 卡都瑞恩医药公司 | 用于治疗镰状细胞病的pde9抑制剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6372648A (ja) * | 1986-09-16 | 1988-04-02 | Sumitomo Pharmaceut Co Ltd | 新規不飽和脂肪酸誘導体 |
| GB8813012D0 (en) * | 1988-06-02 | 1988-07-06 | Norsk Hydro As | Non-b-oxidizable fatty acid analogues to reduce concentration of cholesterol & triglycerides in blood of mammals |
| JPH06511479A (ja) * | 1991-06-24 | 1994-12-22 | ウィメンズ アンド チルドレンズ ホスピタル | マラリアおよびその他の疾患を治療するための方法および組成物 |
| WO1994022848A1 (en) * | 1993-03-29 | 1994-10-13 | Pace Asciak Cecil R | Hepoxilin analogs useful as anti-inflammatory agents |
| US5767156A (en) * | 1993-10-06 | 1998-06-16 | Peptide Technology Limited | Polyunsaturated fatty acids and uses thereof |
-
1995
- 1995-10-13 AT AT95933988T patent/ATE210640T1/de not_active IP Right Cessation
- 1995-10-13 JP JP8512793A patent/JPH10507179A/ja active Pending
- 1995-10-13 CN CN95196205A patent/CN1088058C/zh not_active Expired - Fee Related
- 1995-10-13 CA CA002202503A patent/CA2202503C/en not_active Expired - Fee Related
- 1995-10-13 WO PCT/AU1995/000677 patent/WO1996011908A1/en active IP Right Grant
- 1995-10-13 US US08/817,430 patent/US6376688B1/en not_active Expired - Fee Related
- 1995-10-13 KR KR1019970702434A patent/KR100463709B1/ko not_active Expired - Fee Related
- 1995-10-13 DE DE69524639T patent/DE69524639T2/de not_active Expired - Lifetime
- 1995-10-13 EP EP95933988A patent/EP0869941B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0869941B1 (de) | 2001-12-12 |
| DE69524639T2 (de) | 2002-08-08 |
| EP0869941A4 (de) | 1998-10-14 |
| EP0869941A1 (de) | 1998-10-14 |
| WO1996011908A1 (en) | 1996-04-25 |
| JPH10507179A (ja) | 1998-07-14 |
| CA2202503A1 (en) | 1996-04-25 |
| CN1088058C (zh) | 2002-07-24 |
| DE69524639D1 (de) | 2002-01-24 |
| KR970707088A (ko) | 1997-12-01 |
| KR100463709B1 (ko) | 2005-08-04 |
| CA2202503C (en) | 2008-07-15 |
| CN1163609A (zh) | 1997-10-29 |
| US6376688B1 (en) | 2002-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |