ATE214061T1 - Azetidinonverbindung und verfahren zu ihrer herstellung - Google Patents
Azetidinonverbindung und verfahren zu ihrer herstellungInfo
- Publication number
- ATE214061T1 ATE214061T1 AT93118085T AT93118085T ATE214061T1 AT E214061 T1 ATE214061 T1 AT E214061T1 AT 93118085 T AT93118085 T AT 93118085T AT 93118085 T AT93118085 T AT 93118085T AT E214061 T1 ATE214061 T1 AT E214061T1
- Authority
- AT
- Austria
- Prior art keywords
- substituent
- azetidinone compound
- production
- oxygen atom
- ring
- Prior art date
Links
- -1 AZETIDINONE COMPOUND Chemical class 0.000 title abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/04—Preparation by forming the ring or condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30366292 | 1992-11-13 | ||
| JP11146093 | 1993-05-13 | ||
| JP16918293 | 1993-07-08 | ||
| JP23815593 | 1993-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE214061T1 true ATE214061T1 (de) | 2002-03-15 |
Family
ID=27469913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93118085T ATE214061T1 (de) | 1992-11-13 | 1993-11-08 | Azetidinonverbindung und verfahren zu ihrer herstellung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5442055A (de) |
| EP (1) | EP0597423B1 (de) |
| JP (1) | JP2897153B2 (de) |
| KR (3) | KR100231223B1 (de) |
| AT (1) | ATE214061T1 (de) |
| CA (1) | CA2102772C (de) |
| DE (1) | DE69331652T2 (de) |
| DK (1) | DK0597423T3 (de) |
| ES (1) | ES2173087T3 (de) |
| IL (2) | IL107532A (de) |
| PT (1) | PT597423E (de) |
| SG (1) | SG50416A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5731431A (en) * | 1991-12-26 | 1998-03-24 | Nippon Soda Co., Ltd. | Process for preparing 4-substituted azetidinone derivatives |
| US6011150A (en) * | 1992-11-13 | 2000-01-04 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
| US5550229A (en) * | 1993-06-23 | 1996-08-27 | Tanabe Seiyaku Co., Ltd. | Alkylation process for preparing azetidinone compound and starting compound therefor |
| DE69405922T2 (de) * | 1993-06-30 | 1998-01-29 | Nippon Soda Co | Verfahren zur Herstellung von 4-substituierten Azetidinon-Derivaten |
| JPH09143156A (ja) * | 1995-11-17 | 1997-06-03 | Tanabe Seiyaku Co Ltd | アセトキシアゼチジノン誘導体の製法及びその合成中間体 |
| JP3450193B2 (ja) * | 1998-07-24 | 2003-09-22 | 高砂香料工業株式会社 | ４−置換アゼチジノン誘導体の製造方法 |
| KR100377448B1 (ko) * | 2000-08-10 | 2003-03-26 | 동화약품공업주식회사 | 카바페넴 항생물질의 중간체 및 그의 제조방법 |
| JP2008056564A (ja) * | 2004-11-12 | 2008-03-13 | Shionogi & Co Ltd | アゼチジノン誘導体の製造方法 |
| DK2326648T3 (da) | 2008-07-30 | 2012-10-15 | Ranbaxy Lab Ltd | Fremgangsmåde til fremstillingen af carbapenemforbindelser |
| CN102725290B (zh) | 2009-07-27 | 2016-03-09 | 吉利德科学股份有限公司 | 作为离子通道调节剂的稠合杂环化合物 |
| CN103096977B (zh) | 2010-07-02 | 2017-02-15 | 吉利德科学公司 | 作为离子通道调节剂的稠杂环化合物 |
| WO2012154760A1 (en) | 2011-05-10 | 2012-11-15 | Gilead Sciences, Inc. | Fused heterocyclic compounds as sodium channel modulators |
| TWI622583B (zh) | 2011-07-01 | 2018-05-01 | 基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
| CN108774188A (zh) * | 2018-07-23 | 2018-11-09 | 湖北宇阳药业有限公司 | 一种美罗培南中间体的制备方法 |
| CN110025619B (zh) * | 2019-04-29 | 2022-03-22 | 江苏汉阔生物有限公司 | 美罗培南中间体在制备抗氧化药物中的应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4194047A (en) * | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
| EP0010348A1 (de) * | 1978-09-12 | 1980-04-30 | Imperial Chemical Industries Plc | Heterocyclische Trichlormethyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US4350631A (en) * | 1980-12-18 | 1982-09-21 | Merck & Co., Inc. | 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates |
| JPS5910570A (ja) * | 1982-07-08 | 1984-01-20 | Wakamoto Pharmaceut Co Ltd | 新規イソカルボスチリル誘導体及びその製法 |
| JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | １―置換カルバペネム―３―カルボン酸誘導体 |
| JPS615081A (ja) * | 1984-06-18 | 1986-01-10 | Sankyo Co Ltd | １−置換カルバペネム−３−カルボン酸誘導体の製造法 |
| DK270685A (da) * | 1984-06-29 | 1985-12-30 | Hoffmann La Roche | Carbapenemderivater |
| JPS6225286A (ja) * | 1985-07-26 | 1987-02-03 | 株式会社東芝 | 核融合装置用電源装置 |
| JPS6277384A (ja) * | 1985-10-01 | 1987-04-09 | Nippon Redarii Kk | アゼチジン−２−オン誘導体及びその製造方法 |
| EP0213610A1 (de) * | 1985-08-31 | 1987-03-11 | Lederle (Japan) Ltd. | Azetidin-2-on-Derivate und Verfahren zu ihrer Herstellung |
| JPS62252785A (ja) * | 1986-01-08 | 1987-11-04 | Sankyo Co Ltd | ４−置換β−ラクタム化合物 |
| JPS62169781A (ja) * | 1986-01-21 | 1987-07-25 | Sankyo Co Ltd | β−ラクタム化合物 |
| JP2789190B2 (ja) * | 1986-01-27 | 1998-08-20 | 住友製薬株式会社 | 新規なβ−ラクタム誘導体およびその製造法 |
| GB8607921D0 (en) * | 1986-04-01 | 1986-05-08 | Fujisawa Pharmaceutical Co | 3,4-disubstituted-2-azetidinone derivatives |
| JP2510860B2 (ja) * | 1987-02-02 | 1996-06-26 | 住友製薬株式会社 | 新規なβ−ラクタム誘導体の製造方法 |
| JPS63284176A (ja) * | 1987-05-15 | 1988-11-21 | Nippon Redarii Kk | （１ｒ，５ｒ，６ｓ）−６−〔（１ｒ）−１−ヒドロキシエチル〕−１−メチルカルバペネム−３−カルボン酸誘導体の高立体選択的製造方法 |
| FI91258C (fi) * | 1988-04-01 | 1994-06-10 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten 2-(heterosyklyylitio)karbapeneemijohdannaisten valmistamiseksi |
| JPH02178262A (ja) * | 1988-12-28 | 1990-07-11 | Sumitomo Pharmaceut Co Ltd | １―（２′―ハロプロピオニル）ピロリジン―２―オン誘導体 |
| JPH0662547B2 (ja) * | 1989-01-10 | 1994-08-17 | 田辺製薬株式会社 | グリシン誘導体 |
| JPH02292269A (ja) * | 1989-05-06 | 1990-12-03 | Lederle Japan Ltd | 活性アミド化合物 |
| CA2050255C (en) * | 1990-09-07 | 1997-02-04 | Tameo Iwasaki | 1-methylcarbapenem derivatives and process for preparation thereof |
| ES2157214T3 (es) * | 1991-12-26 | 2001-08-16 | Nippon Soda Co | Procedimiento para producir derivados de azetidinona sustituidos en posicion 4. |
-
1993
- 1993-11-05 US US08/148,917 patent/US5442055A/en not_active Expired - Lifetime
- 1993-11-08 AT AT93118085T patent/ATE214061T1/de active
- 1993-11-08 PT PT93118085T patent/PT597423E/pt unknown
- 1993-11-08 DK DK93118085T patent/DK0597423T3/da active
- 1993-11-08 ES ES93118085T patent/ES2173087T3/es not_active Expired - Lifetime
- 1993-11-08 SG SG1996000950A patent/SG50416A1/en unknown
- 1993-11-08 DE DE69331652T patent/DE69331652T2/de not_active Expired - Lifetime
- 1993-11-08 EP EP93118085A patent/EP0597423B1/de not_active Expired - Lifetime
- 1993-11-08 IL IL10753293A patent/IL107532A/en not_active IP Right Cessation
- 1993-11-09 CA CA002102772A patent/CA2102772C/en not_active Expired - Lifetime
- 1993-11-12 JP JP5283148A patent/JP2897153B2/ja not_active Expired - Lifetime
- 1993-11-12 KR KR1019930024017A patent/KR100231223B1/ko not_active Expired - Lifetime
-
1997
- 1997-09-26 IL IL12184297A patent/IL121842A0/xx unknown
-
1999
- 1999-04-22 KR KR1019990014373A patent/KR100252404B1/ko not_active Expired - Lifetime
- 1999-08-16 KR KR1019990033676A patent/KR100256863B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| SG50416A1 (en) | 1998-07-20 |
| PT597423E (pt) | 2002-06-28 |
| DK0597423T3 (da) | 2002-05-21 |
| KR100252404B1 (en) | 2000-04-15 |
| KR100231223B1 (ko) | 1999-11-15 |
| KR100256863B1 (ko) | 2000-05-15 |
| JP2897153B2 (ja) | 1999-05-31 |
| IL107532A0 (en) | 1994-02-27 |
| US5442055A (en) | 1995-08-15 |
| CA2102772C (en) | 2001-04-03 |
| IL121842A0 (en) | 1998-02-22 |
| IL107532A (en) | 1999-06-20 |
| DE69331652D1 (de) | 2002-04-11 |
| CA2102772A1 (en) | 1994-05-14 |
| EP0597423A2 (de) | 1994-05-18 |
| DE69331652T2 (de) | 2002-10-17 |
| ES2173087T3 (es) | 2002-10-16 |
| EP0597423B1 (de) | 2002-03-06 |
| JPH07165760A (ja) | 1995-06-27 |
| KR940011460A (ko) | 1994-06-21 |
| EP0597423A3 (de) | 1995-04-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |