ATE215074T1 - Piperazinone als inhibitoren von blutplattchenaggregation - Google Patents
Piperazinone als inhibitoren von blutplattchenaggregationInfo
- Publication number
- ATE215074T1 ATE215074T1 AT96912246T AT96912246T ATE215074T1 AT E215074 T1 ATE215074 T1 AT E215074T1 AT 96912246 T AT96912246 T AT 96912246T AT 96912246 T AT96912246 T AT 96912246T AT E215074 T1 ATE215074 T1 AT E215074T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazinones
- compounds
- platele
- aggregation
- inhibitors
- Prior art date
Links
- 230000002776 aggregation Effects 0.000 title 1
- 238000004220 aggregation Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127217 antithrombotic drug Drugs 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002008 hemorrhagic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical class O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10191195 | 1995-04-26 | ||
| JP20313295 | 1995-08-09 | ||
| JP7786796 | 1996-03-29 | ||
| PCT/JP1996/001139 WO1996033982A1 (en) | 1995-04-26 | 1996-04-25 | Piperazinones useful as inhibitors of platelet aggregation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE215074T1 true ATE215074T1 (de) | 2002-04-15 |
Family
ID=27302551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96912246T ATE215074T1 (de) | 1995-04-26 | 1996-04-25 | Piperazinone als inhibitoren von blutplattchenaggregation |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5935963A (de) |
| EP (1) | EP0822931B1 (de) |
| AT (1) | ATE215074T1 (de) |
| AU (1) | AU5514296A (de) |
| CA (1) | CA2216162A1 (de) |
| DE (1) | DE69620165T2 (de) |
| WO (1) | WO1996033982A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| EP0750913A3 (de) * | 1995-06-30 | 1997-11-05 | Takeda Chemical Industries, Ltd. | Disaccharide enthaltende gefriergetrocknete Zubereitung für pharmazeutische Verwendung |
| AU6120298A (en) | 1997-03-07 | 1998-09-22 | Takeda Chemical Industries Ltd. | 2-peperazinone-1-acetic acid derivatives and their use |
| DE69835430T2 (de) | 1997-05-30 | 2007-03-08 | Takeda Pharmaceutical Co. Ltd. | Sulfonamidderivate, ihre herstellung und verwendung |
| US6403595B1 (en) | 1998-02-05 | 2002-06-11 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, processes for producing the same and utilization thereof |
| WO1999052861A1 (de) * | 1998-04-09 | 1999-10-21 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Neue benzylguanidinderivate für die therapie, in-vivo- und in-vitro-diagnostik |
| EP0950658A1 (de) * | 1998-04-13 | 1999-10-20 | Takeda Chemical Industries, Ltd. | 2-Piperazinone-1-acetic acid dihydrochloridderivat als Hemmer von Plättchenaggregation |
| EP0950407B1 (de) | 1998-04-14 | 2002-09-04 | Hisamitsu Pharmaceutical Co., Inc. | Die Verwendung eines GP IIb/IIIa Antagonisten für die Herstellung eines Medikamentes geeignet zur transdermalen Applikation mittels Iontophorese |
| US7655658B2 (en) * | 2001-08-10 | 2010-02-02 | Palatin Technologies, Inc. | Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds |
| US7732451B2 (en) * | 2001-08-10 | 2010-06-08 | Palatin Technologies, Inc. | Naphthalene-containing melanocortin receptor-specific small molecule |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| AU2002331064B2 (en) * | 2001-08-10 | 2007-08-23 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7354923B2 (en) * | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7718802B2 (en) | 2001-08-10 | 2010-05-18 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7968548B2 (en) | 2003-05-01 | 2011-06-28 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine compounds with diamine groups |
| US7727991B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific single acyl piperazine compounds |
| US7727990B2 (en) | 2003-05-01 | 2010-06-01 | Palatin Technologies, Inc. | Melanocortin receptor-specific piperazine and keto-piperazine compounds |
| US7709484B1 (en) | 2004-04-19 | 2010-05-04 | Palatin Technologies, Inc. | Substituted melanocortin receptor-specific piperazine compounds |
| US7834017B2 (en) | 2006-08-11 | 2010-11-16 | Palatin Technologies, Inc. | Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents |
| JP2013518618A (ja) * | 2010-02-01 | 2013-05-23 | ザ・ホスピタル・フォー・シック・チルドレン | 再狭窄を治療および予防するための遠隔虚血コンディショニング |
| SG10201502031XA (en) | 2010-03-31 | 2015-05-28 | Hospital For Sick Children | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
| SG184463A1 (en) | 2010-04-08 | 2012-11-29 | Hospital For Sick Children | Use of remote ischemic conditioning for traumatic injury |
| JP2016512709A (ja) | 2013-03-15 | 2016-05-09 | ザ・ホスピタル・フォー・シック・チルドレンＴｈｅ Ｈｏｓｐｉｔａｌ Ｆｏｒ Ｓｉｃｋ Ｃｈｉｌｄｒｅｎ | 遠隔虚血コンディショニングを用いてオートファジをモジュレートする方法 |
| US10098779B2 (en) | 2013-03-15 | 2018-10-16 | The Hospital For Sick Children | Treatment of erectile dysfunction using remote ischemic conditioning |
| US10252052B2 (en) | 2013-03-15 | 2019-04-09 | The Hospital For Sick Children | Methods relating to the use of remote ischemic conditioning |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2945680B2 (ja) * | 1988-09-09 | 1999-09-06 | 旭硝子株式会社 | ペプチド誘導体およびその用途 |
| ATE155482T1 (de) * | 1990-04-06 | 1997-08-15 | Jolla Cancer Res Found | Verfahren und verbindung zur behandlung von thrombose |
| DE4035961A1 (de) * | 1990-11-02 | 1992-05-07 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| UA39849C2 (uk) * | 1991-03-26 | 2001-07-16 | Ф.Хоффманн-Ля Рош Аг | ПОХІДНІ N-АЦИЛ-<font face="Symbol">a</font>-АМІНОКИСЛОТИ АБО ЇХ ФІЗІОЛОГІЧНО ПРИЙНЯТНІ СОЛІ, ПРОСТІ АБО СКЛАДНІ ЕФІРИ, АМІДИ АБО ЇХ ГІДРАТИ ЯК ФАРМАЦЕВТИЧНО АКТИВНІ РЕЧОВИНИ |
| US5545658A (en) * | 1991-03-26 | 1996-08-13 | Hoffman-La Roche Inc. | Amino acid derivatives |
| JPH06509551A (ja) * | 1991-04-05 | 1994-10-27 | ジェネンテク，インコーポレイテッド | Ｇｐ ＩＩ↓ｂＩＩＩ↓ａに対する高い特異性を有する血小板凝集阻害剤 |
| JPH0529858A (ja) * | 1991-07-23 | 1993-02-05 | Canon Inc | 信号処理装置 |
| US5294713A (en) * | 1991-08-23 | 1994-03-15 | Takeda Chemical Industries, Ltd. | 2-piperazinone compounds and their use |
| HUT70045A (en) * | 1993-06-17 | 1995-09-28 | Takeda Chemical Industries Ltd | 2-piperazinone derivatives parmaceutical compositions containing them and process for producing them |
| US6117455A (en) * | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
-
1996
- 1996-04-25 US US08/669,375 patent/US5935963A/en not_active Expired - Fee Related
- 1996-04-25 DE DE69620165T patent/DE69620165T2/de not_active Expired - Fee Related
- 1996-04-25 AT AT96912246T patent/ATE215074T1/de active
- 1996-04-25 WO PCT/JP1996/001139 patent/WO1996033982A1/en active IP Right Grant
- 1996-04-25 EP EP96912246A patent/EP0822931B1/de not_active Expired - Lifetime
- 1996-04-25 CA CA002216162A patent/CA2216162A1/en not_active Abandoned
- 1996-04-25 AU AU55142/96A patent/AU5514296A/en not_active Abandoned
-
1998
- 1998-09-01 US US09/144,995 patent/US6020334A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0822931B1 (de) | 2002-03-27 |
| AU5514296A (en) | 1996-11-18 |
| US6020334A (en) | 2000-02-01 |
| WO1996033982A1 (en) | 1996-10-31 |
| CA2216162A1 (en) | 1996-10-31 |
| EP0822931A1 (de) | 1998-02-11 |
| US5935963A (en) | 1999-08-10 |
| DE69620165D1 (de) | 2002-05-02 |
| DE69620165T2 (de) | 2002-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE215074T1 (de) | Piperazinone als inhibitoren von blutplattchenaggregation | |
| TR199800019T1 (xx) | Trombosit topaklanmas�n� �nleyici yeni maddeler. | |
| IL110031A0 (en) | Phenyl heterocycles, their manufacture and pharmaceutical compositions containing them | |
| AU7453498A (en) | Sulfonamide derivatives, their production and use | |
| ATE273279T1 (de) | 2,3,5-trisubstituierte pyridine als inhibitoren von cyclooxygenase-2 | |
| DE69214397D1 (de) | 2-Substituierte Indane-2-Carboxyalkyl-Verbindungen mit Enkephalinase und ACE-Hemmwirkung | |
| DE69715888D1 (de) | Pyridylalken- und pyridylalkin-säureamide als cytostatika und immunosuppressive arzneimittel | |
| DE69220744D1 (de) | 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung | |
| FI941222A0 (fi) | Ei-peptidyyli-tyyppisiä integriini-inhibiittoreita, jotka ovat spesifisiä GPIIbIIIa-reseptorin suhteen | |
| MX9708782A (es) | Heterociclos de 5 anillos como inhibidores de la adhesion de leucocitos y antagonistas de vla-4. | |
| EA199900137A1 (ru) | Замещенные пиридины в качестве избирательных ингибиторов циклооксигеназы-2 | |
| BR9611400A (pt) | "agentes antimicobiano de benzoxazina". | |
| GR74571B (de) | ||
| DE69410254D1 (de) | Behandlung von mycobakteriellen erkrankungen durch verabreichung von bakrerientötende, durchlässigkeitserhöhende proteinfragmente | |
| FI972308A0 (fi) | 2-substituoituja 1,2,5-tiadiatsolidin-3-oni-1,1-dioksideja ja niitä sisältäviä koostumuksia ja menetelmiä niiden käyttämiseksi | |
| ES2164109T3 (es) | Derivados de n-(3-piperidinilcarbonil)-beta-alanina como antagonistas de paf. | |
| DK0636027T3 (da) | Angiotensin-II-antogonister mod sygdomme forbundet med forringet neuronal ledningshastighed, især diabetisk neuropati | |
| FR2686339B1 (fr) | Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. | |
| ES2096874T3 (es) | Inhibidor de la proteasa de hiv util para el tratamiento del sida. | |
| DE60041399D1 (de) | Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen | |
| TW200510437A (en) | Phosphinane compound with immunomodulating activity | |
| NO943126D0 (no) | 3-alkyloksy-, aryloksy- eller arylalkyloksybenzo-[bÅtiofen-2-karboksamider som hemmere av celleadhesjon | |
| ATE293602T1 (de) | 2-aminopyridine als inhibitoren von cyclooxygenase-2 | |
| FR2766183B1 (fr) | Medicaments contenant des polyhydroxybutylpyrazines, les polyhydroxybutylpyrazines nouvelles et leur preparation | |
| EP0369810A3 (de) | PAF-Antagonisten als Antihyperendothelinemie-Mittel |