ATE216262T1 - Biologisch abbaubare polymermischungen zur arzneistoffabgabe - Google Patents

Biologisch abbaubare polymermischungen zur arzneistoffabgabe

Info

Publication number: ATE216262T1
Authority: AT; Austria
Prior art keywords: blends; polyesters; polyanhydrides; polymers; drug delivery
Prior art date: 1991-02-01

Application number

AT92908387T

Other languages

English (en)

Inventor

Abraham J Domb

Manoj Maniar

Andrew T S Haffer

Original Assignee

Massachusetts Inst Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-01

Filing date

1992-01-31

Publication date

2002-05-15

1992-01-31 Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology

2002-05-15 Application granted granted Critical

2002-05-15 Publication of ATE216262T1 publication Critical patent/ATE216262T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
- C08L67/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L73/00—Compositions of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08L59/00 - C08L71/00; Compositions of derivatives of such polymers
- C08L73/02—Polyanhydrides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Compositions Of Macromolecular Compounds (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT92908387T 1991-02-01 1992-01-31 Biologisch abbaubare polymermischungen zur arzneistoffabgabe ATE216262T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US64892791A	1991-02-01	1991-02-01
PCT/US1992/000877 WO1992013567A1 (en)	1991-02-01	1992-01-31	Biodegradable polymer blends for drug delivery

Publications (1)

Publication Number	Publication Date
ATE216262T1 true ATE216262T1 (de)	2002-05-15

Family

ID=24602790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92908387T ATE216262T1 (de)	1991-02-01	1992-01-31	Biologisch abbaubare polymermischungen zur arzneistoffabgabe

Country Status (10)

Country	Link
US (1)	US5919835A (de)
EP (1)	EP0568651B1 (de)
JP (1)	JP3137337B2 (de)
AT (1)	ATE216262T1 (de)
AU (1)	AU669479B2 (de)
CA (1)	CA2101742C (de)
DE (1)	DE69232555T2 (de)
DK (1)	DK0568651T3 (de)
ES (1)	ES2176189T3 (de)
WO (1)	WO1992013567A1 (de)

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US20030077317A1 (en) *	1996-06-25	2003-04-24	Brown University Research Foundation	Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US7066884B2 (en)	1998-01-08	2006-06-27	Sontra Medical, Inc.	System, method, and device for non-invasive body fluid sampling and analysis
US20040171980A1 (en)	1998-12-18	2004-09-02	Sontra Medical, Inc.	Method and apparatus for enhancement of transdermal transport
WO2000063268A1 (en) *	1999-04-16	2000-10-26	Wm. Marsh Rice University	Poly(propylene fumarate) cross linked with poly(ethylene glycol)
US6113678A (en) *	1999-09-23	2000-09-05	Xerox Corporation	Hot melt inks containing polyanhydrides
US20070196415A1 (en) *	2002-11-14	2007-08-23	Guohua Chen	Depot compositions with multiple drug release rate controls and uses thereof
US20030170289A1 (en) *	2001-11-14	2003-09-11	Guohua Chen	Injectable depot compositions and uses thereof
KR20040058101A (ko) *	2001-11-14	2004-07-03	알자 코포레이션	카테터 주입가능한 데포 조성물 및 그의 용도
US20040001889A1 (en)	2002-06-25	2004-01-01	Guohua Chen	Short duration depot formulations
US7160551B2 (en) *	2002-07-09	2007-01-09	The Board Of Trustees Of The University Of Illinois	Injectable system for controlled drug delivery
CA2494400A1 (en) *	2002-07-31	2004-02-05	Alza Corporation	Injectable multimodal polymer depot compositions and uses thereof
MXPA05001242A (es) *	2002-07-31	2005-06-08	Alza Corp	Composiciones de deposito inyectable y usos de las mismas.
US20040086569A1 (en) *	2002-08-13	2004-05-06	Medtronic, Inc.	Active agent delivery systems, medical devices, and methods
EP1539265B1 (de) *	2002-08-13	2007-09-26	Medtronic, Inc.	System zur abgabe von wirkstoffen mit einem hydrophoben cellulose-derivat
JP2006500088A (ja) *	2002-08-13	2006-01-05	メドトロニック・インコーポレーテッド	ポリマーの被覆及び支持体間の改良された付着を示す医用デバイス
WO2004014447A1 (en) *	2002-08-13	2004-02-19	Medtronic, Inc.	Active agent delivery system including a poly(ethylene-co-(meth)acrylate), medical device, and method
US20040127978A1 (en) *	2002-08-13	2004-07-01	Medtronic, Inc.	Active agent delivery system including a hydrophilic polymer, medical device, and method
US6911400B2 (en) *	2002-11-05	2005-06-28	International Business Machines Corporation	Nonlithographic method to produce self-aligned mask, articles produced by same and compositions for same
US20050064038A1 (en) *	2003-08-13	2005-03-24	Dinh Thomas Q.	Active agent delivery systems including a single layer of a miscible polymer blend, medical devices, and methods
CA2535345A1 (en) *	2003-08-13	2005-03-03	Medtronic, Inc.	Active agent delivery systems including a miscible polymer blend, medical devices, and methods
FR2859909B1 (fr) *	2003-09-22	2007-09-07	Biomerieux Sa	Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation
US20080038317A1 (en) *	2004-09-10	2008-02-14	Chin-Ming Chang	Therapeutic Lacrimal Canalicular Inserts And Related Methods
US20060142234A1 (en) *	2004-12-23	2006-06-29	Guohua Chen	Injectable non-aqueous suspension
US7432069B2 (en)	2005-12-05	2008-10-07	Sontra Medical Corporation	Biocompatible chemically crosslinked hydrogels for glucose sensing
US20070200268A1 (en) *	2006-02-24	2007-08-30	Vipul Dave	Implantable device prepared from solution processing
US20070200271A1 (en) *	2006-02-24	2007-08-30	Vipul Dave	Implantable device prepared from melt processing
AU2008222757B2 (en)	2007-03-07	2011-06-09	Echo Therapeutics, Inc.	Transdermal analyte monitoring systems and methods for analyte detection
ES2387419T3 (es) *	2007-04-27	2012-09-21	Echo Therapeutics, Inc.	Dispositivo de permeación de piel para la detección de analitos o administración transdérmica de medicamentos
JP5139003B2 (ja) *	2007-08-17	2013-02-06	国立大学法人京都工芸繊維大学	組成物およびフィルム
US20090286907A1 (en) *	2008-01-23	2009-11-19	Beltz Mark W	Fumaric Acid/Diol Polyesters and Their Manufacture and Use
TWI501781B (zh) *	2010-12-10	2015-10-01	Ind Tech Res Inst	可控制釋放的組合物及其製造方法
CA2931547A1 (en)	2013-12-09	2015-06-18	Durect Corporation	Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CN109021215B (zh) *	2018-07-11	2021-03-02	中山大学	一种pH敏感型聚扁桃酸纳米药物载体及其制备方法和应用
BR112021007900A2 (pt) *	2018-08-10	2021-08-03	Ephemeral Solutions, Inc.	partículas contendo agentes de coloração e métodos de uso das mesmas
BR112022013784A2 (pt)	2020-01-13	2022-10-11	Durect Corp	Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
EP4277702A1 (de)	2021-01-12	2023-11-22	Durect Corporation	Systeme zur wirkstofffreisetzung mit verzögerter freisetzung und zugehörige verfahren

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Publication number	Priority date	Publication date	Assignee	Title
US4522804A (en) *	1983-01-03	1985-06-11	Verex Laboratories, Inc.	Constant release rate solid oral dosage formulations of propranolol
US4757128A (en) *	1986-08-01	1988-07-12	Massachusetts Institute Of Technology	High molecular weight polyanhydride and preparation thereof
US4888176A (en) *	1984-05-21	1989-12-19	Massachusetts Institute Of Technology	Controlled drug delivery high molecular weight polyanhydrides
US4886870A (en) *	1984-05-21	1989-12-12	Massachusetts Institute Of Technology	Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4891225A (en) *	1984-05-21	1990-01-02	Massachusetts Institute Of Technology	Bioerodible polyanhydrides for controlled drug delivery
US4764364A (en) *	1986-02-25	1988-08-16	S R I International	Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4841968A (en) *	1986-09-26	1989-06-27	Southern Research Institute	Antithrombotic/thrombolytic suture and methods of making and using the same
US4789724A (en) *	1986-10-17	1988-12-06	Massachusetts Institute Of Technology	Preparation of anhydride copolymers
US4863457A (en) *	1986-11-24	1989-09-05	Lee David A	Drug delivery device
FR2612198A1 (fr) *	1987-03-27	1988-09-16	Tyndale Plains Hunter Ltd	Composition de polyurethane hydrophile et article qui en est produit
US4857311A (en) *	1987-07-31	1989-08-15	Massachusetts Institute Of Technology	Polyanhydrides with improved hydrolytic degradation properties
WO1990009783A1 (en) *	1989-02-22	1990-09-07	Massachusetts Institute Of Technology	Delivery system for controlled release of bioactive factors
US5356630A (en) *	1989-02-22	1994-10-18	Massachusetts Institute Of Technology	Delivery system for controlled release of bioactive factors
ES2093647T3 (es) *	1989-06-05	1997-01-01	Massachusetts Inst Technology	Polimeros bioerosionables para la liberacion de farmacos en los huesos.
US4997904A (en) *	1989-08-25	1991-03-05	Nova Pharmaceutical Corporation	Aromatic polyanhydride compositions
DE59003337D1 (de) *	1989-10-16	1993-12-09	Danubia Petrochem Polymere	Pressling mit retardierter Wirkstofffreisetzung.

1992
- 1992-01-31 EP EP92908387A patent/EP0568651B1/de not_active Expired - Lifetime
- 1992-01-31 AT AT92908387T patent/ATE216262T1/de not_active IP Right Cessation
- 1992-01-31 AU AU16432/92A patent/AU669479B2/en not_active Ceased
- 1992-01-31 ES ES92908387T patent/ES2176189T3/es not_active Expired - Lifetime
- 1992-01-31 DE DE69232555T patent/DE69232555T2/de not_active Expired - Fee Related
- 1992-01-31 CA CA002101742A patent/CA2101742C/en not_active Expired - Fee Related
- 1992-01-31 JP JP04508130A patent/JP3137337B2/ja not_active Expired - Fee Related
- 1992-01-31 WO PCT/US1992/000877 patent/WO1992013567A1/en active IP Right Grant
- 1992-01-31 DK DK92908387T patent/DK0568651T3/da active
- 1992-12-23 US US07/995,952 patent/US5919835A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2101742C (en)	2005-04-12
JP3137337B2 (ja)	2001-02-19
AU669479B2 (en)	1996-06-13
AU1643292A (en)	1992-09-07
US5919835A (en)	1999-07-06
DK0568651T3 (da)	2002-08-05
CA2101742A1 (en)	1992-08-02
JPH06508863A (ja)	1994-10-06
EP0568651A1 (de)	1993-11-10
DE69232555T2 (de)	2002-10-31
EP0568651A4 (en)	1996-11-27
ES2176189T3 (es)	2002-12-01
DE69232555D1 (de)	2002-05-23
WO1992013567A1 (en)	1992-08-20
EP0568651B1 (de)	2002-04-17

Publication	Publication Date	Title
ATE216262T1 (de)	2002-05-15	Biologisch abbaubare polymermischungen zur arzneistoffabgabe
CA2474701A1 (en)	1995-05-26	Preparation of biodegradeable microparticles containing a biologically active agent
CA2348016A1 (en)	2000-05-04	Controlled release liquid delivery compositions with low initial drug burst
DE69121675D1 (de)	1996-10-02	Mikrosphäre enthaltende pharmazeutische Zusammensetzung mit kontrollierter Freigabe und Verfahren zur Herstellung
DK0386967T3 (da)	1995-11-20	Coatingmateriale til styring af lægemiddelafgivelse i langtidsvirkende formuleringer
DE69523044D1 (de)	2001-11-08	Block- und pfropfcopolymere und dazu gehöriges verfahren
KR930016091A (ko)	1993-08-26	거의 수불용성인 약제의 고체 분산액을 제조하는 방법
NO20000913L (no)	2000-02-24	Sfæriske mikropartikler inneholdende lineære polysakkarider
KR910007516A (ko)	1991-05-30	서방성 활성 화합물을 함유한 압착물
IL111647A0 (en)	1995-01-24	Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles, their preparation and pharmaceutical compositions containing them
BRPI9908893B8 (pt)	2021-05-25	composição polimérica líquida para a liberação controlada de substâncias bioativas hidrofóbicas.
ATE47669T1 (de)	1989-11-15	Chirurgische nahtmaterialien.
BR9910481A (pt)	2001-01-09	Composição farmacêutica para comprimido de liberação não-contìnua
ATE281155T1 (de)	2004-11-15	Medikamentöse verabreichung von proteinen aus polymergemischen
DE59909717D1 (de)	2004-07-22	Verfahren zur Herstellung von festen Dosierungsformen
BG105303A (en)	2001-11-30	Pharmaceutical compositions comprising ibuprofen and domperidone
GR1000266B (el)	1992-05-12	Μεθοδος παρασκευης μιας συνθεσης βασισμενης σε πολυεστερα για την ελεγχομενη εκλυση φαρμακευτικων ουσιων.
KR100316145B1 (ko)	2002-11-23	방출조절형 농약조성물의 제조방법 및 그 농약조성물
RS49840B (sr)	2008-08-07	Tečne polimerne smeše za kontrolisano oslobađanje bioaktivnih supstanci
KR910016314A (ko)	1991-11-05	항생활성 성분의 치과용 국소지속성 투여조성물
DE3770658D1 (de)	1991-07-18	Injizierbare arzneiformulierungen von substanzen mit allgemeiner anaesthetischer wirkung.
NZ335409A (en)	2000-12-22	Use of a burst free controlled release poly(lactide/glycolide) microcapsule pharmaceutical formulation
KR950703947A (ko)	1995-11-17	고형 의약용 조성물의 제조방법(method of manufacturing composition for solid medicine)

Legal Events

Date	Code	Title	Description
2002-09-15	UEP	Publication of translation of european patent specification
2010-10-15	REN	Ceased due to non-payment of the annual fee